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Digitale Medien

Hereditary motor endplate disease (med) of the mouse: Observations on dissociated myogenic cells and their development in culture (1980)

Jockusch, Harald ; Burkart, Werner ; Burger, Max M.

Springer

Cell & tissue research 207 (1980), S. 241-248

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Details

ISSN: 1432-0878

Schlagwort(e): Neuromuscular disease ; Muscle culture ; Tissue dissociation ; Immunofluorescence

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary Myogenic cells from mice homozygous for the lethal mutation “motor endplate disease” (med/med) were grown in culture. Like muscle cells taken from wild type (+/?) litter mates they fused to form myotubes which contracted, developed cross striations, and exposed acetylcholine receptors (AChR) on their surface. However, a decrease of 30% in the number of mononucleated cells per unit fresh weight of muscle was observed as early as 2–3 days postnatal, i.e., at least one week prior to the onset of physiological symptoms. Hence, in addition to influencing the functional maintenance of motor endplates, the med gene seems to control early events in muscle development.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00237809

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