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Digitale Medien

Morphogenesis of human colon cancer cells with fetal rat mesenchymes in organ culture (1986)

Fukamachi, H. ; Mizuno, T. ; Kim, Y. S.

Springer

Cellular and molecular life sciences 42 (1986), S. 312-315

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Details

ISSN: 1420-9071

Schlagwort(e): Human colon cancer cells ; morphogenesis ; carcinoembryonic antigen ; secretory components ; organ culture

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Medizin

Notizen: Summary The morphogenesis and cytodifferentiation of human colon cancer cells (LS174T and HT29) were examined by combining cancer cells with fetal rat digestive-tract mesenchyme in organ culture. LS174T cells migrated into the mesenchyme to form glandular structures composed of single columnar cells with their nuclei oriented basally, while HT29 cells formed cell masses with little lumen formation. Immunohistochemical studies with antibodies against carcinoembryonic antigen and secretory components showed that the composition of cell surface glycoproteins was not necessarily reversed to the normal type, even when neoplastic cells exhibited normal glandular structures.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01942518

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