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  • 1
    Digitale Medien
    Digitale Medien
    Combined Administration of a 5-Hydroxytryptamine (5-HT)1D Antagonist and a 5-HT Reuptake Inhibitor Synergistically Increases 5-HT Release in Guinea Pig Hypothalamus In Vivo (1996)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 67 (1996), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: In vivo microdialysis in guinea pig hypothalamus was used to study the effect of serotonin [5-hydroxytryptamine (5-HT)] subtype 1D autoreceptor blockade on the increase in extracellular 5-HT levels produced by a selective 5-HT reuptake inhibitor (SSRI). Administration of the selective 5-HT1D antagonist GR127935 at 0.3 mg/kg had no effect, but 5 mg/kg significantly increased extracellular levels of 5-HT and 5-hydroxyindoleacetic acid to 135% of basal values. Moreover, at these doses GR127935 significantly attenuated the decrease in extracellular 5-HT levels following local perfusion with the selective 5-HT1D agonist CP-135,807. The SSRI sertraline at 2 mg/kg increased 5-HT levels to 130% of basal levels. The combination of this low dose of sertraline with either dose of GR127935 resulted in a pronounced, long-lasting increase in 5-HT levels to 230% of basal values. These results indicate that the effects of an SSRI on terminal 5-HT are significantly enhanced by coadministration of a 5-HT1D antagonist and confirm that in addition to somatodendritic 5-HT1A autoreceptors, terminal 5-HT1D autoreceptors mitigate the effect of SSRIs on terminal 5-HT. As such, antagonists of the 5-HT1D autoreceptor could be useful as rapidly acting antidepressants and may shorten the onset of antidepressant action when combined with SSRIs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1471-4159.1996.67052204.x
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  • 2
    Digitale Medien
    Digitale Medien
    Problems faced by R&D managers in Canadian federal government laboratories (1988)
    Oxford, UK : Blackwell Publishing Ltd
    R & D management 18 (1988), S. 0 
    Details
    ISSN: 1467-9310
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Wirtschaftswissenschaften
    Notizen: The paper conducts a critical review of the problems faced by middle to first-line managers in managing R&D in Canadian government laboratories. The data come from the published literature, interviews with R&D managers, and information obtained from government employees undergoing training as R&D managers.The problems are numerous and serious. They arise from a multiplicity of causes related to underfunding and bureaucratic management practices that do not allow for the special nature of R&D. Hiring freezes, staff reductions, travel restrictions and reductions in training budgets are all consequences of underfunding, resulting in an aging workforce and technological obsolescence. Bureaucratic administration rules set by central agencies constrain the freedom of R&D managers to manage effectively, and limit low-level participation in policy-making and planning. The result is that too many management posts are filled by under-achieving scientists and engineers, with resultant consequences for originality and efficiency.The authors believe that the only cure is to undertake proper funding, recognise the special operational needs of R&D management, and select managers for managerial ability in addition to technical competence.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1467-9310.1988.tb00561.x
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  • 3
    Digitale Medien
    Digitale Medien
    A STUDY OF THE ZIRCONATES. (1896)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 18 (1896), S. 434-444 
    Details
    ISSN: 1520-5126
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/ja02091a004
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  • 4
    Digitale Medien
    Digitale Medien
    SOME OF THE PROPERTIES OF CALCIUM CARBIDE. (1895)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 17 (1895), S. 306-310 
    Details
    ISSN: 1520-5126
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/ja02159a012
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  • 5
    Digitale Medien
    Digitale Medien
    ON β-HEPTYLAMINE.1,2 (1899)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 21 (1899), S. 1027-1031 
    Details
    ISSN: 1520-5126
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/ja02061a009
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  • 6
    Digitale Medien
    Digitale Medien
    Inversion component in the solvolytic displacement reactions of alkyl-substituted vinyl trifluoromethanesulfonates (1972)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 94 (1972), S. 3626-3627 
    Details
    ISSN: 1520-5126
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/ja00765a061
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  • 7
    Digitale Medien
    Digitale Medien
    Olefinic cyclization at a vinyl cation center. Inversion preference for intramolecular nucleophilic substitution by a double bond (1972)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 94 (1972), S. 3627-3629 
    Details
    ISSN: 1520-5126
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/ja00765a062
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  • 8
    Digitale Medien
    Digitale Medien
    Accounting for Enron: shareholder value and stakeholder interests (2005)
    Oxford, UK : Blackwell Publishing Ltd.
    Corporate governance 13 (2005), S. 0 
    Details
    ISSN: 1467-8683
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Politikwissenschaft , Wirtschaftswissenschaften
    Notizen: The catastrophe caused by the failure of Enron could not compare with the damage this company would have caused if it had succeeded. The relentless emphasis on the importance of shareholder value in recent times has created the conditions for the disconnection of corporations such as Enron from their essential moral underpinnings, encouraging them to concentrate exclusively on financial performance, and to neglect not just the wider stakeholder interests of customers and employees, but the essential interests of the economies and communities in which they operate. The problem with established economic theories of corporate governance is that they misconceive the irreducible core of corporate governance, at the same time as underestimating the complexity of the phenomenon.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1467-8683.2005.00454.x
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  • 9
    Digitale Medien
    Digitale Medien
    “Valuing” Corporate Governance: an introduction (2004)
    Oxford, UK : Blackwell Publishing Ltd.
    Corporate governance 12 (2004), S. 0 
    Details
    ISSN: 1467-8683
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Politikwissenschaft , Wirtschaftswissenschaften
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1467-8683.2004.00350.x
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  • 10
    Digitale Medien
    Digitale Medien
    Cycles of Crisis and Regulation: the enduring agency and stewardship problems of corporate governance (2004)
    Oxford, UK : Blackwell Publishing Ltd.
    Corporate governance 12 (2004), S. 0 
    Details
    ISSN: 1467-8683
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Politikwissenschaft , Wirtschaftswissenschaften
    Notizen: Corporate governance crisis and reform is essentially cyclical. Waves of corporate governance reform and increased regulation occur during periods of recession, corporate collapse and re-examination of the viability of regulatory systems. During long periods of expansion, active interest in the conformance aspects of governance diminishes, as companies and shareholders become again more concerned with the generation of wealth, rather than in ensuring governance mechanisms are working appropriately for the retention of wealth, and its use for agreed purposes. This cyclical historical saga revolves around the enduring agency and stewardship dilemmas of governance. Complacency concerning corporate governance during confident times compounds ensuing crises. Such dilemmas are universal in market systems, though internationally with different systems of corporate governance the unwinding of this saga has occurred at different times, for different reasons, and with different consequences. Corporate governance is about wealth generation and risk management, and these duties require continuous and simultaneous performance. Avoiding mandatory restrictive over-regulation requires active market regulation, particularly at times of expansion. The drive to make corporate governance both improve corporate performance and enhance corporate accountability will continue.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1467-8683.2004.00354.x
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