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Digitale Medien

Epithelioid angiosarcoma of the intestinal tract with endothelin-1-like immunoreactivity (1993)

Watanabe, Kazuo ; Hoshi, Nobuo ; Suzuki, Tomohiro ; [weitere]

Springer

Virchows Archiv 423 (1993), S. 309-314

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Details

ISSN: 1432-2307

Schlagwort(e): Angiosarcoma ; Intestinal tract ; JC70 ; Endothelin ; Epithelioid angiosarcoma

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Two rare cases of intestinal epithelioid angiosarcoma arising in the sigmoid colon and small intestine are reported. The small intestinal tumours were located in the duodenum and upper jejunum. All tumours showed reddish-black protuberant masses with comparatively clear margins. Histology reveals solid and epithelioid growth of large polygonal cells, mimicking undifferentiated carcinoma. Vascular differentiation such as lumina containing red cells and intracytoplasmic vacuolization is noticed. Intense immunoreactivity toUlex europaeus agglutinin I and JC70 (CD31), and sporadic positive reaction to factor VIII related antigen were detected in one case but not in the other. However, both tumours have cells which show intense endothelin-1 immunoreactivity. Positive immunostaining occurred with low molecular weight keratins suggesting epithelial differentiation and suggested epithelioid angiosarcoma as a diagnosis, a specific entity within angiosarcoma. Because of their histological features, epithelioid angiosarcomas may be confused with undifferentiated carcinomas. Endothelin-1-like immunoreactivity seems to be a good marker for this type of angiosarcoma, even when the tumour cells lack usual marker substances for endothelial cells.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01606896

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