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Digitale Medien

Subacute sclerosing panencephalitis (SSPE) reappraisal of nuclear, cytoplasmic and axonal inclusions ultrastructural study of eight cases (1974)

Martinez, A. Julio ; Ohya, Tatsuo ; Jabbour, J. T. ; [weitere]

Springer

Acta neuropathologica 28 (1974), S. 1-13

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ISSN: 1432-0533

Schlagwort(e): Subacute Sclerosing Panencephalitis ; Intranuclear Inclusions ; Intracytoplasmic ; Intraaxonal Inclusions ; Nuclear Bodies

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary A description of “nuclear bodies”, “intranuclear crystalloid tubules” and intracytoplasmic inclusions from eight SSPE cases in clinical stage 2 and 3 is presented. The development and evolution of nuclear bodies is proposed. No correlation between the clinical stage of the disease and the different morphological aspects of nuclear bodies was found. The presence of nuclear bodies in SSPE is a consistent feature and consequently these “structures” should have a definite diagnostic value in clinically suspected cases of SSPE. All the cases showed various types of intranuclear inclusions ranging from “simple” nuclear bodies to granular “beaded” nuclear bodies and paramyxovirus nucleocapsids. Intralysosomal nucleocapsids were found in one case. In one instance intraaxonal paramyxovirus nucleocapsids were found. Intranuclear elongated tubules and/or filamentous paracrystalline bundles, some arranged in lattice-like fashion were also found. No apparent morphological relationship was demonstrated between these structures and the “simple” nuclear bodies, granular “beaded” nuclear bodies and “nucleocapsids.” From these observations, we propose that “simple” nuclear bodies evolve into paramyxovirus nucleocapsids tubules and that there is a migration of virus or virus-related structures from nuclei to cytoplasm and then to axoplasm.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00687513

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Digitale Medien

Demonstration of the third antigenically distinct outer membrane lipoprotein (OmlA) in Actinobacillus pleuropneumoniae serotype 7 (1998)

Ito, Hiroya ; Osaki, Makoto ; Uchida, Ikuo ; [weitere]

Oxford, UK : Blackwell Publishing Ltd

FEMS microbiology letters 167 (1998), S. 0

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ISSN: 1574-6968

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Biologie

Notizen: The gene encoding an outer membrane lipoprotein (OmlA) of Actinobacillus pleuropneumoniae strain WF83 (serotype 7 reference strain), designated omlA7, was sequenced. The amino acid sequence of OmlA7 showed 64.5 and 71.6% identity to that of OmlA from serotypes 1 (OmlA1) and 5 (OmlA5), respectively. The first 134 amino acids of OmlA7 were identical to those of OmlA5. A Southern blot analysis revealed the presence of a gene highly homologous to the omlA7 in the reference strains of serotypes 3, 4, 6, and 7. A Western blot analysis using a specific antiserum against a recombinant OmlA7 detected expression of the homologous proteins in the serotypes 4, 6, and 7 reference strains and a serotype 3 field strain, but not in a serotype 3 reference strain. The data demonstrate the third antigenically distinct OmlA is expressed in A. pleuropneumoniae.