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Prenatal treatment of congenital adrenal hyperplasia: Report of a new case (1990)

Loeuille, G. A. ; David, M. ; Forest, M. G.

Springer

European journal of pediatrics 149 (1990), S. 237-240

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Details

ISSN: 1432-1076

Schlagwort(e): Congenital adrenal hyperplasia ; 21-Hydroxylase deficiency ; Prenatal diagnosis and treatment ; Dexamethasone

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract A mother at risk for 21-hydroxylase deficiency was treated with oral dexamethasone (0.5 mg 12 hourly) from early pregnancy, in an attempt to prevent in utero virilization in case of a female fetus. Fetal karyotype was 46,XX, and because of a possible intra HLA recombination, treatment was continued to term. The newborn had a modest virilization and hormonal studies confirmed the diagnosis of congenital adrenal hyperplasia (CAH). This observation and review of the literature suggest that efficient prenatal treatment of CAH requires a higher and more frequent dosage of dexamethasone.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02106280

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