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  • 2005-2009  (23)
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  • 11
    Electronic Resource
    Electronic Resource
    TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells (2005)
    [s.l.] : Nature Publishing Group
    Nature medicine 11 (2005), S. 653-660 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Leprosy enables investigation of mechanisms by which the innate immune system contributes to host defense against infection, because in one form, the disease progresses, and in the other, the infection is limited. We report that Toll-like receptor (TLR) activation of human monocytes induces rapid ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm1246
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    Paper (German National Licenses)
    Fulltext
  • 12
    Electronic Resource
    Electronic Resource
    The snake venom protein botrocetin acts as a biological brace to promote dysfunctional platelet aggregation (2005)
    [s.l.] : Nature Publishing Group
    Nature structural & molecular biology 12 (2005), S. 152-159 
    Details
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Botrocetin is a snake venom protein that enhances the affinity of the A1 domain of plasma von Willebrand factor (vWF) for the platelet receptor glycoprotein Ibα (GPIbα), an event that contributes to bleeding and host death. Here we describe a kinetic and crystallographic analysis of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nsmb892
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    Paper (German National Licenses)
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  • 13
    Electronic Resource
    Electronic Resource
    Practitioner Review: The contribution of attachment theory to child custody assessments (2005)
    Oxford, UK : Blackwell Publishing
    The @journal of child psychology and psychiatry 46 (2005), S. 0 
    Details
    ISSN: 1469-7610
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Background:  The area of child custody assessments continues to fail to meet the evidence-based threshold now established in clinical practice. This is despite the existence, for many years, of published guidelines governing the practice of custody assessments available from a number of professional bodies.Methods:  This article reviews the potential of attachment theory to contribute to the conceptualization of custody evaluations, clinical assessment, and the development of evidence-based practice. Particular attention is paid to specific instruments used to assess attachment in clinic and non-clinic settings.Results:  Guidelines concerning child custody assessments highlight the particular importance of assessing attachment and parent–child relationship quality. However, measures often used in the course of a custody assessment are not backed up with empirical research, and the measures that are supported by empirical research have been slow to influence practice. There may be conceptual and measurement advantages of considering an attachment research-informed custody assessment.Discussion:  Attachment theory has obvious conceptual relevance for the child custody context. Further clinical research is needed to demonstrate the usefulness of attachment research measures; research of this kind may shed important light on the development and resilience of affectional bonds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1469-7610.2004.00396.x
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    Paper (German National Licenses)
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  • 14
    Electronic Resource
    Electronic Resource
    Social evolution Kin preference in a social microbe (2006)
    [s.l.] : Nature Publishing Group
    Nature 442 (2006), S. 881-882 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Kin recognition helps cooperation to evolve in many animals, but it is uncertain whether microorganisms can also use it to focus altruistic behaviour on relatives. Here we show that the social amoeba Dictyostelium purpureum prefers to form groups with its own kin in situations where some ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/442881a
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    Paper (German National Licenses)
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  • 15
    Electronic Resource
    Electronic Resource
    Structure of the catalytic domain of the hepatitis C virus NS2-3 protease (2006)
    [s.l.] : Nature Publishing Group
    Nature 442 (2006), S. 831-835 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Hepatitis C virus is a major global health problem affecting an estimated 170 million people worldwide. Chronic infection is common and can lead to cirrhosis and liver cancer. There is no vaccine available and current therapies have met with limited success. The viral RNA genome encodes a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature04975
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    Paper (German National Licenses)
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  • 16
    Electronic Resource
    Electronic Resource
    ANTI-INFECTIVE THERAPY AT END OF LIFE: ETHICAL DECISION-MAKING IN HOSPICE-ELIGIBLE PATIENTS (2005)
    Oxford, UK : Blackwell Publishing Ltd.
    Bioethics 19 (2005), S. 0 
    Details
    ISSN: 1467-8519
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Philosophy
    Notes: Clear guidelines addressing the ethically appropriate use of anti-infectives in the setting of hospice care do not exist. There is lack of understanding about key treatment decisions related to infection treatment for patients who are eligible for hospice care. Ethical concerns about anti-infective use at the end of life include: (1) delaying transition to hospice, (2) prolonging a dying process, (3) prescribing regimens incongruent with a short life expectancy and goals of care, (4) increasing the reservoir of potential resistant pathogens, (5) placing unreasonable costs on a capitated hospice system. Although anti-infectives are thought to be relatively safe, they can place a burden on patients and be inconsistent to particular care plans. The current complex, and at times fragmented, medical care often fails to address these issues in decision-making. In many ways, the ethics governing the end of life decisions related to dialysis, hydration/nutrition, and hypercalcemia parallel those of anti-infectives. In this article we articulate important elements in ethical decision-making in the application of anti-infectives for patients who are eligible for hospice care, and we point to the need for prospective studies to help refine particular guidelines in these cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-8519.2005.00450.x
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    Paper (German National Licenses)
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  • 17
    Electronic Resource
    Electronic Resource
    Remifentanil sedation in a critically ill obstetric patient (2005)
    Oxford, UK : Blackwell Science Ltd
    Anaesthesia 60 (2005), S. 0 
    Details
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2044.2005.04414.x
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    Paper (German National Licenses)
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  • 18
    Electronic Resource
    Electronic Resource
    SUMMER LOW FLOWS IN NEW ENGLAND DURING THE 20TH CENTURY (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the American Water Resources Association 41 (2005), S. 0 
    Details
    ISSN: 1752-1688
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Notes: : High springtime river flows came earlier by one to two weeks in large parts of northern New England during the 20th Century. In this study it was hypothesized that late spring/early summer recessional flows and late summer/early fall low flows could also be occurring earlier. This could result in a longer period of low flow recession and a decrease in the magnitude of low flows. To test this hypothesis, variations over time in the magnitude and timing of low flows were analyzed. To help understand the relation between low flows and climatic variables in New England, low flows were correlated with air temperatures and precipitation. Analysis of data from 23 rural, unregulated rivers across New England indicated little evidence of consistent changes in the timing or magnitude of late summer/early fall low flows during the 20th Century. The interannual variability in the timing and magnitude of the low flows in northern New England was explained much more by the interannual variability in precipitation than by the interannual variability of air temperatures. The highest correlation between the magnitude of the low flows and air temperatures was with May through November temperatures (r =−0.37, p= 0.0017), while the highest correlation with precipitation was with July through August precipitation (r = 0.67, p 〉 0.0001).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1752-1688.2005.tb03744.x
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    Paper (German National Licenses)
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  • 19
    Electronic Resource
    Electronic Resource
    Lead and cadmium uptake in the marine fungi Corollospora lacera and Monodictys pelagica (2005)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology ecology 53 (2005), S. 0 
    Details
    ISSN: 1574-6941
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: This study provides observations on the effects of lead and cadmium ions on the growth of two species of marine fungi, Corollospora lacera and Monodictys pelagica. On solid media lead appeared to have no effect on the radial rate of growth of fungi. Exposure to increasing cadmium concentrations on solid media resulted in significant reduction (P 〈 0.05) in the radial mycelial growth rates of both fungi, especially in M. pelagica. These results reveal significant difference in species sensitivity toward cadmium and, essentially, insensitivity toward lead exposure. In liquid cultures, the metal content of mycelia (metal mass found in mycelium, in mg), and the concentration of metal in dry mycelium (metal mass in 1 g of mycelium, in mg g−1) were both found to increase (P 〈 0.05) with the increase in the metal cation concentration, while mycelium dry mass decreased. As it was observed on solid media, cadmium cation affected more severely (P 〈 0.05) the growth of M. pelagica in liquid cultures. Ergosterol content of mycelia of C. lacera exposed to increasing cadmium cation concentration decreased, similarly to the trend observed for dry mycelial mass. It was found that ca. 93% of all lead sequestered by C. lacera is located extracellularly. M. pelagica was found to bioaccumulate over 60 mg of cadmium and over 6 mg of lead per 1 g of mycelium, while C. lacera bioaccumulated over 7 mg of cadmium and up to 250 mg of lead per 1 g of mycelium. Overall, the results indicate that both metal ions affect the growth of marine fungi with lead being accumulated extracellularly in the mycelia. Both metals accumulated by fungi may then enter the marine ecosystem food web, of which marine fungi are integral members.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/j.femsec.2005.02.009
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    Paper (German National Licenses)
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  • 20
    Electronic Resource
    Electronic Resource
    Low-Temperature Sintering of Nanoscale Silver Paste for Large-Area Joints in Power Electronics Modules (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 353-358 (Sept. 2007), p. 2948-2953 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Today, reflow soldering is a commonly used technique to establish large-area joints inpower electronics modules. These joints are needed to attach large-area (〉1 cm2) powersemiconductor chips to the substrate, e.g., a direct-bond copper substrate, and the multichip modulesubstrate to a copper base plate for heat spreading. Thermal performance, specifically thermalconductivity and thermomechanical reliability, of these large-area joints are critical to the electricalperformance and lifetime of the power modules. Soft solder alloys, including the lead-tin eutecticand lead-free alternatives, have low thermal conductivities and are highly susceptible to fatiguefailure. As demands mount for higher power density, higher junction temperature, and longerlifetime out of the power modules, reliance on solder-based joining is becoming a barrier for furtheradvancement in power electronics systems. Recently, we successfully demonstrated lowtemperaturesintering of nanoscale silver paste as a lead-free solution for achieving highperformance,high-reliability, and high-temperature interconnection of small devices (〈0.09 cm2).In this paper, we report the results of our study to extend the low-temperature sintering technique tolarge-area joints. The study involved redesigning the organic and inorganic components of thenanoscale silver paste, analyzing the burnout kinetics of the various organic species sandwichedbetween large-area plates, and developing desirable temperature-time profile to improve sinteringand bonding strength of the joints
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/55/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.353-358.2948.pdf
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