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Digitale Medien

Evaluation of treatment for gastro-oesophageal reflux disease with a proton pump inhibitor, and relationship between gastro-oesophageal reflux disease and Helicobacter pylori infection in Japan (2004)

Muramatsu, A. ; Azuma, T. ; Okajima, T. ; [weitere]

Oxford, UK : Blackwell Publishing Ltd

Alimentary pharmacology & therapeutics 20 (2004), S. 0

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ISSN: 1365-2036

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Background : Effective therapy for gastro-oesophageal reflux disease (GERD) is associated with improvement in health-related quality of life. It remains unclear whether Helicobacter pylori infection protects against GERD.Aim : We evaluated the relationship between GERD and H. pylori, and whether the health-related quality of life score improved after medical treatment.Methods : We enrolled 151 outpatients with upper abdominal symptoms; 81 patients received omeprazole 20 mg/day for 2 weeks. Health-related quality of life was assessed using the Gastrointestinal Symptom Rating Scale (GSRS) and the Psychological General Well-Being (PGWB) index. H. pylori infection was diagnosed by serum antibody or endoscopy and the relationship between GERD and H. pylori was evaluated.Results : In GERD patients, the mean GSRS score improved from 2.20 to 1.67 following treatment (P 〈 0.01). The mean GSRS reflux symptom score improved from 2.96 to 1.67 (P 〈 0.01). The mean PGWB score improved from 96.36 to 107.34 (P 〈 0.01). All scores in GERD patients significantly improved compared with non-GERD patients. The H. pylori-positive ratio was 66.15% in GERD patients and 65.21% in non-GERD patients (P = 0.94).Conclusions : Health-related quality of life is useful for evaluation of proton pump inhibitor treatment in GERD. The presence of H. pylori was not associated with the prevalence of GERD.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1365-2036.2004.01983.x

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Digitale Medien

Effects of acrylic acid incorporation on the pressure–temperature behavior and the calorimetric properties of poly(N-isopropylacrylamide) in aqueous solutions (2000)

Yamazaki, Y. ; Tada, T. ; Kunugi, S.

Springer

Colloid & polymer science 278 (2000), S. 80-83

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ISSN: 1435-1536

Schlagwort(e): Key words Poly(N-isopropylacrylamide) ; Poly(acrylic acid) ; Cloud point ; Thermoresponsive polymer ; High pressure

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Maschinenbau

Notizen: Abstract We studied the effects of pH on the pressure–temperature dependence of coil–collapse transition for aqueous solutions of copolymers of N-isopropylacrylamide and acrylic acid (Ac). At low pressures, the transition temperature (T tr) increased with pressure, but T tr decrease with increasing pressure at pressures higher than 50–100 MPa. By increasing the pH, the transition contour shifted to a higher temperature. When the Ac content was increased, the effects of pH became more evident. From a calorimetric study at atmospheric pressure, ΔH tr was found to become smaller by increasing the portion of the ionized residues in the copolymer. The ratio to the van't Hoff enthalpy changes became larger with an increase in pH, which indicated that the production of charge decreased the cooperative domain size.