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  • 11
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Fatigue & fracture of engineering materials & structures 25 (2002), S. 0 
    ISSN: 1460-2695
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The fatigue fracture surfaces of specimens of heat treated hard steels which failed in the regime of N = 105 to 5 × 108 cycles, were investigated by optical microscopy and SEM. Specimens having a longer fatigue life had a particular morphology beside the inclusion at the fracture origin. The particular morphology looked optically dark and in the previous paper it was named the Optically Dark Area, ODA. The roughness inside ODA is larger than outside ODA. The relative size of the ODA to the size of the inclusion at the fracture origin increases with increase in fatigue life. Thus, the ODA is considered to have a crucial role in the mechanism of ultra long life fatigue failure. Direct evidences of existence of hydrogen at the inclusion at fracture origin are presented. It is presumed that the ODA is made by the cyclic stress coupled with the hydrogen which is trapped by the inclusion at the fracture origin. To verify the influence of hydrogen, specimens containing different levels of hydrogen were prepared by different heat treatments. The results obtained by fatigue tests of these specimens suggest that the hydrogen trapped by inclusions is a crucial factor which causes the ultra long fatigue failure of high strength steels. Aspects of the double S–N curve are also discussed in terms of experimental methods, specimen size and statistical distribution of inclusions sizes.
    Type of Medium: Electronic Resource
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  • 12
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: summary  In the present study, the compositional changes and knoop hardness of the cavity floor prepared by Er,Cr:YSGG laser irradiation was compared with that of the conventional bur cavity. Fifteen laser and 15 bur cavities were cross-sectioned, and subjected to atomic analysis by SEM-EDX and knoop hardness test. Statistical analyses were performed using the Mann–Whitney U-test; a value of P 〈 0·01 was considered significant. Surface characteristics of the prepared cavities were also investigated by light microscopy and scanning electron microscopy (SEM). The results showed that the quantities of Ca (Ca weight %) and P (P weight %) were increased significantly in the laser cavity floor but no significant differences were found between the Ca/P ratio and knoop hardness number of laser and bur cavities. The SEM observation revealed that the lased cavity surface was irregular and there was also the absence of a smear layer; the orifice of dentinal tubules was exposed. Er,Cr:YSGG laser device is considered as one of the most effective and safe devices for cavity preparation because of its many advantages. This includes easy delivery system, minimal thermal damage to the surrounding tissues, minimal thermal-induced changes of dental hard tissue compositions, and favourable surface characteristic.
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 33 (2000), S. 1241-1245 
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: A synchrotron radiation X-ray powder diffractometer for samples of very small amount has been developed to collect high-quality diffraction patterns under extreme conditions, i.e. at low temperature and/or high pressure. A new cylindrical imaging plate (CIP) is used as a detector, in addition to a conventional flat-type imaging plate (FIP). By using the CIP system, the diffraction data in a diffraction angle range −44 ≤ 2θ ≤ 122° are collected with a dynamic range of about 106. The alignment of the diffractometer, measurement and analysis are automatically operated by a workstation. A performance test shows that the CIP system has spatial resolution of about 0.07° with a dynamic range of 106. The diffraction pattern of a standard sample of Si measured by the CIP system has high quality; the refinement of the structure reaches Rw = 3.68% even in the case of a small amount of sample (about 2 µg) and a short exposure time (60 s). Examples of experiments at low temperatures under ambient and high pressures are also presented.
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    [s.l.] : Macmillian Magazines Ltd.
    Nature 423 (2003), S. 965-968 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The effect of ‘colossal magnetoresistance’ (CMR) in hole-doped manganites—an abnormal decrease of resistivity when a magnetic field is applied—has attracted significant interest from researchers in the past decade. But the underlying mechanism for the CMR phenomenon is ...
    Type of Medium: Electronic Resource
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  • 15
    ISSN: 1572-8838
    Keywords: ruthenium oxide ; titanium oxide ; chlorine ; oxygen ; DEMS ; porous electrode
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Electrical Engineering, Measurement and Control Technology
    Notes: Abstract Chlorine and oxygen evolving at RuO2/Ti and RuO2–TiO2/Ti anodes have been simultaneously determined at electrode potentials from 1.0 to about 2V (vs Ag/AgCl) by differential electrochemical mass spectroscopy (DEMS). On the RuO2/Ti anodes, the threshold electrode potential for oxygen evolution increased with a decrease in RuO2 loading, while the chlorine evolution potential was unchanged. Low RuO2 loading anodes gave a high chlorine evolution ratio under various constant electrolysis potentials. On the RuO2–TiO2/Ti anodes, the threshold electrode potential for oxygen evolution increased with an increase in the TiO2 content more remarkably than that for chlorine evolution. High TiO2 content anodes gave a high chlorine evolution ratio at various constant electrolysis potentials. The combination of RuO2 and TiO2 exhibits a remarkable effect with respect to the enhancement of chlorine evolution selectivity.
    Type of Medium: Electronic Resource
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  • 16
    Electronic Resource
    Electronic Resource
    Springer
    Extremes 2 (1999), S. 123-147 
    ISSN: 1572-915X
    Keywords: Fatigue limit ; maximum defect ; projection area ; inclusion ; extremes ; Gumbel ; 62N05 ; 60D05
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract The method explained in this paper for quantitative evaluation of fatigue limit for materials containing defects is based on the experimental evidences that inhomogeneities and micro-notches can be treated like cracks. First, the basic concept of the √area parameter model is explained introducing the various data obtained by the first author's group for over last 15 years. Evidences are shown that small cracks, defects and nonmetallic inclusions having the same value of the square root of projection area, √area, have the identical influence on the fatigue limit regardless of different stress concentration factors. Various applications of these concepts to various defect types and microstructural inhomogeneities are shown. Since the estimation of fatigue strength is related to the estimation of the size of maximum defects occurring in a piece, the methods for searching the defects and the quality control of materials with respect to inclusion or defect rating as well as their statistical implications are discussed.
    Type of Medium: Electronic Resource
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  • 17
    ISSN: 1572-879X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Partially protonated alkaline mordenites showed higher activity per acid amount below 573 K than acidic zeolites for the selective reduction of NO with C3H6 in the presence of O2, which can be related to a high concentration of NO3 - species in the zeolite channels.
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    Springer
    Bioprocess and biosystems engineering 13 (1995), S. 223-229 
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract For the advancement of Human Genome Project, we have developed an automated DNA sequencing system ‘HUGA-I.’ It is composed of several automated instruments and transfer robots connecting them. In this paper we describe the results of the performance evaluation test of HUGA-I. Although some of the system units showed good performances, the total performance of the HUGA-I was about 1/6 of the designed value. By revealing principal reasons of this poor performance, we would like to contribute to the automation in genome analysis, particularly in human genome analysis. Since the sequence technology advanced remarkably in these years, the system units of HUGA-I become older than those which are now commercially available and the throughput of it is out of our expectations. Nevertheless, we believe that it is meaningful to introduce the exact performance of HUGA-I and present the bottle neck points in the automating sequencing processes. Because, automation in the gene analysis is ultimately important, in particular for the analysis of large genomes such as the human genome. The aims of this paper are to introduce the results in performance evaluation of HUGA-I and to elucidate the bottle neck points in the automation of sequencing processes.
    Type of Medium: Electronic Resource
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  • 19
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 327-328 (Jan. 2000), p. 441-444 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 20
    Electronic Resource
    Electronic Resource
    Springer
    Clinical and experimental nephrology 4 (2000), S. 293-299 
    ISSN: 1437-7799
    Keywords: Key words Calcium receptor ; HEK293 ; NPS R-568 ; Calcimimetics ; Intracellular Ca2+
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. The Ca2+ receptor (CaR) plays a key role in maintaining Ca2+ homeostasis by its presence in the parathyroid gland and kidney. NPS R-568 (referred to as KRN568 in Japan) is a phenylalkylamine compound that activates the CaR. It has been difficult to study Ca2+-sensing mechanisms because of the lack of cell model systems that express reasonable numbers of CaR coupled to downstream effectors and physiological responses. This study was conducted to evaluate the effects of NPS R-568 on the CaR both in vitro and in vivo. Methods. Western blotting analysis of CaR was performed to confirm the existence of CaR in human embryonic kidney 293 (HEK293) cells expressing human CaR (HuCaR-HEK293). Intracellular Ca2+ concentration ([Ca2+]i) and inositol trisphosphate (IP3) content were measured in HuCaR-HEK293 after the addition of NPS R-568 and other agonists. Male Sprague-Dawley rats received NPS R-568 orally, and plasma Ca2+ levels and serum parathyroid hormone (PTH) levels were determined. Results. Western blotting analysis of the crude plasma membrane fraction prepared from HuCaR-HEK293 identified bands immunoreactive with a human CaR-specific antibody. NPS R-568 dose-dependently and stereoselectively increased [Ca2+]i in HuCaR-HEK293, whereas NPS R-568 had no effects in wild-type HEK293 cells. These effects of NPS R-568 were associated with an increase in cytoplasmic IP3 levels and were abolished in the absence of extracellular Ca2+. Single oral administration of NPS R-568 suppressed PTH secretion, followed by decreased plasma Ca2+ levels, in normal rats. Conclusions. These results suggest that NPS R-568 activates CaR and suppresses PTH secretion in vitro and in vivo.
    Type of Medium: Electronic Resource
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