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  • 11
    Electronic Resource
    Electronic Resource
    An examination of a possible pharmacokinetic interaction between nifedipine and antipyrine (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 405-407 
    Details
    ISSN: 1432-1041
    Keywords: Nifedipine ; antipyrine ; interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The influence of 2 weeks oral intake of nifedipine (2×20 mg) on the oxidative metabolism of antipyrine was investigated in 12 normal volunteers, who had 1050 mg antipyrine solution orally before and after the course of nifedipine. There were no statistically significant differences in the saliva pharmacokinetic parameters of antipyrine on both occasions. However, the metabolite profile of antipyrine in urine showed a significant reduction in the amount of norantipyrine excreted after compared to that before nifedipine administration (16.5 vs 19.6%). This may have implications for drugs that share a similar demethylation pathway with norantipyrine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315420
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  • 12
    Electronic Resource
    Electronic Resource
    Temporary anion states of hydrogen cyanide, methyl cyanide, and methylene dicyanide, selected cyanoethylenes, benzonitrile, and tetracyanoquinodimethane (1992)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 96 (1992), S. 7570-7578 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100198a017
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  • 13
    Electronic Resource
    Electronic Resource
    Coherent Foucault imaging: A method for imaging magnetic domain structures in thin films (1994)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 76 (1994), S. 5349-5355 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A method for imaging magnetic domain structures in the transmission electron microscope is described. Coherent Foucault imaging provides a direct means of producing a magnetic interferogram which reveals the quantitative distribution of magnetic induction across the specimen. The technique requires the high coherence of a field-emission gun system and the ability to position an aperture accurately to cut part of the diffraction pattern. A simple analytical theory, together with computer simulations and experimental results, is presented to demonstrate the power of the technique.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.357188
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  • 14
    Electronic Resource
    Electronic Resource
    The multidisciplinary management of a family with epithelial ovarian cancer (1992)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 99 (1992), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To describe the management of a family with an inherited predisposition to ovarian and breast cancer. Particular attention is paid to the problems of contraception, screening, prophylactic surgery and hormone replacement therapy.Setting The multidisciplinary Grampian Familial Epithelial Overian Cancer Study Group.Subjects 162 members of a family extending over five generations. In the third generation, five of the 10 women died with epithelial ovarian cancer. Three women in generation IV have developed premenopausal breast cancer. There are now 78 family members in the fifth generation aged between 2 and 22 years.Interventions Counselling of female family members is started at the age of 18 years. The combined oral contraceptive pill is advocated to suppress ovulation. Gynaecological follow-up after the age of 28 includes yearly pelvic examination, transvaginal ultrasonography and serum CA125 estimation. Laparoscopy with peritoneal cytology is indicated if any part of this yearly assessment is abnormal. Prophylactic oophorectomy is advised between the ages of 35 and 40 years after the family is complete. In generation IV, 20 of the 29 women have undergone prophylactic oophorectomy. Oestrogen hormone replacement therapy with a cyclical progestogen is recommended after prophylactic oophorectomy. Breast cancer screening starts at the age of 25 and involves annual clinical breast examination augmented by mammography and breast ultrasound.Conclusions Only by the careful questioning and recording of family history, including at least third degree relatives (cousins), will similar groups with familial ovarian/breast cancer be identified. When predisposing genes are characterized it will be possible to identify carriers within the family and concentrate clinical effort on them while offering appropriate reassurance to those with decreased risk.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1992.tb14504.x
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  • 15
    Electronic Resource
    Electronic Resource
    The products of Rhizobium genes, psi and pss, which affect exopolysaccharide production, are associated with the bacterial cell surface (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 5 (1991), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Translational fusions between a mutant phoA (lacking its promoter, ribosomal binding site and signal peptide sequence) and Rhizobium‘symbiotic’ genes were isolated. Since these fusions expressed alkaline phosphatase (AP), the product of phoA, the genes into which phoA was inserted apparently specify proteins located in the bacterial periplasm or cell membrane, the compartment in which AP has activity. These genes were psiA and genes upstream of psiA (psiA is required for normal nodule development and strains with multicopy psiA fall to make exopolysaccharide (EPS) and to nodulate). Fusions between phoA and pss (exo) genes, which are required for EPS production, also resulted in the expression of AP indicating that products of these pss genes were located at the cell surface. Using grus fusions to psiA and pssA, we found that the former was expressed in N2-fixing bean root nodules but the latter was not.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1991.tb02140.x
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  • 16
    Electronic Resource
    Electronic Resource
    Secretion of the Rhizobium leguminosarum nodulation protein NodO by haemolysin-type systems (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 6 (1992), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The Rhizobium leguminosarum biovar viciae nodulation protein NodO is partially homologous to haemolysin of Escherichia coli and, like haemolysin, is secreted into the growth medium. The NodO protein can be secreted by a strain of E. coli carrying the cloned nodO gene plus the haemolysin secretion genes hlyBD, in a process that also requires the outer membrane protein encoded by tolC. The related protease secretion genes, prtDEF, from Erwinia chrysanthemi also enable E. coli to secrete NodO. The Rhizobium genes encoding the proteins required for NodO secretion are unlinked to nodO and are unlike other nod genes, since they do not require flavonoids or NodO for their expression. Although proteins similar to NodO were not found in rhizobia other than R. leguminosarum bv. viciae, several rhizobia and an Agrobacterium strain containing the cloned nodO gene were found to have the ability to secrete NodO. These observations indicate that a wide range of the Rhizobiaceae have a protein secretion mechanism analogous to that which secretes haemotysin and related toxins and proteases in the Enterobacteriaceae.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1992.tb02004.x
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  • 17
    Electronic Resource
    Electronic Resource
    Analysis of three nodD genes in Rhizobium leguminosarum biovar phaseoli; nodD 1 is preceded by nolE, a gene whose product is secreted from the cytoplasm (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 4 (1990), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: In a strain of Rhizobium leguminosarum biovar phaseoli, three copies of the regulatory nodulation gene nodD were identified on the Sym plasmid and sequenced. Two were closely linked to each other and the third was near, but not adjacent, to the nodABC genes. Each of these nodD genes could correct the Nod defect of a nodD mutant strain of R. leguminosarum biovar viciae on peas. A truncated form of nodD2 could also correct this mutant, indicating that the C-terminus of NodD2 is not needed for inducing activity. Upstream of nodD1 and in the same operon is a newly described gene, nolE, whose product appears to be exported into the periplasm. Close to nodD2 is another gene, nolP, with no known counterpart in other rhizobia. Both nolP and nolE-nodD1 are preceded by ‘nod-box’ sequences and, in the former case, there appear to be two tandemly repeated nod-box sequences. Mutations in each of the nodD genes and in the nolE and nolP genes did not abolish nodulation or nitrogen fixation on beans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1990.tb00665.x
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  • 18
    Electronic Resource
    Electronic Resource
    Regulatory functions of the three nodD genes of Rhizobium leguminosarum biovar phaseoli (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 4 (1990), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The three nodD genes of a strain of Rhizobium leguminosarum biovar phaseoli were cloned to study their effects on transcription of themselves and of the nodC genes of biovars phaseoli and viciae. Efficient transcription of nodD1 required nodD1 and was enhanced by exposure of the cells to bean exudate consistent with the presence of a nod-box preceding the nolE-nodD1 operon. Transcription of nodD2 and nodDZ was constitutive. nodC of R. leguminosarum biovar phaseoli was activated by each of the nodD genes of that biovar in the absence of inducers but expression was enhanced in cells grown with bean exudate or the flavonoids genistein or naringenin. A mutant of nodD2, tacking 60bp at its 3’end, activated nodC in the presence of inducer, but was defective in regulating certain of the nodD genes. The nodC gene of R. leguminosarum biovar viciae responded differently to the various nodD genes of R. leguminosarum biovar phaseoli than did the nodC of the latter biovar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1990.tb00666.x
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  • 19
    Electronic Resource
    Electronic Resource
    Fluid absent melting of a layered crustal protolith: implications for the generation of anatectic granites (1993)
    Springer
    Contributions to mineralogy and petrology 114 (1993), S. 365-378 
    Details
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract We report the result of H2O-undersaturated melting experiments on charges consisting of a layer of powdered sillimanite-bearing metapelite (HQ36) and a layer of powdered tonalitic gneiss (AGC150). Experiments were conducted at 10 kbar at 900°, 925° and 950°C. When run alone, the pelite yielded ∼40 vol% strongly peraluminous granitic melt at 900°C while the tonalite produced only ∼5 vol% weakly peraluminous granitic melt. At 950°C, the pelite and the tonalite yielded ∼50 vol% and ∼7 vol% granitic melt, respectively. When run side by side, the abundance of melt in the tonalite was ∼10 times higher at all temperatures than when it was run alone. In the pelite, the melt abundance increased by ∼25 vol%. When run alone, biotite dehydration-melting in the tonalite yielded orthopyroxene and garnet in addition to granitic melt. When run side by side only garnet was produced in addition to granitic melt. Experiments of relatively short duration, however, also contained Al-rich orthopyroxene. We suggest that the large increase in melt fraction in the tonalite is mainly a result of increased activity of Al2O3 in the melt, which lowers the temperature of the biotite dehydration-melting reaction. In the pelite, the increase in the abundance of melt is caused by transport of plagioclase component in the melt from the tonalite-layer to the pelite-layer. This has the effect of changing the bulk composition of this layer in the direction of “minimum-temperature” granitic liquids. Our results show that rocks which are poor melt-producers on their own can become very fertile if they occur in contact with rocks that contain components that destabilize the hydrous phase(s) and facilitate dehydration-melting. Because of this effect, the continental crust may have an even greater potential for granitoid melt production than previously thought. Our results also suggest that many anatectic granites most likely contain contributions from two or more different source rocks, which will be reflected in their isotopic and geochemical compositions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01046539
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  • 20
    Electronic Resource
    Electronic Resource
    Excitation and inhibition of rat medial vestibular nucleus neurones by 5-hydroxytryptamine (1993)
    Springer
    Experimental brain research 93 (1993), S. 293-298 
    Details
    ISSN: 1432-1106
    Keywords: Medial vestibular nucleus ; 5-Hydroxytryptamine ; Serotonin ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of 5-hydroxytryptamine (5-HT) and related compounds on the discharge rate of tonically active medial vestibular nucleus (MVN) neurones were studied in an in vitro slice preparation of the dorsal brainstem of the rat. The majority (87 of 107, 82%) of MVN neurones were excited by 5-HT. Nine cells (8%) showed a biphasic response to 5-HT, which consisted of a brief inhibition followed by excitation. Eleven cells (10%) were inhibited by 5-HT. The excitatory effects of 5-HT were mimicked by alpha-methyl-5-HT and antagonised by ketanserin and ritanserin, indicating the involvement of the 5-HT2 subtype of 5-HT receptor. In biphasic cells, blockade of 5-HT2 receptors by ketanserin reduced the excitatory component of the response and revealed an enhanced initial inhibition. The inhibitory effects in biphasic cells, and in cells that showed a pure inhibition in response to 5-HT, were blocked by pindobind-5-HT and mimicked by 8-hydroxy-2-(di-n-propylamino)-tetralin indicating the involvement of 5-HT1A receptors. The significance of these findings in relation to the effects of 5-HT on vestibular reflex function is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00228397
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