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  • 11
    Electronic Resource
    Electronic Resource
    Epidemiological studies of hemorrhagic fever with renal syndrome (HFRS) related virus infection among urban rats in Hokkaido, Japan (1986)
    Springer
    Archives of virology 88 (1986), S. 231-240 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Seroepidemiological studies of hemorrhagic fever with renal syndrome (HFRS) virus infection were carried out among urban rats(Rattus norvegicus andRattus rattus) and small field rodents in Hokkaido, Japan. An urban rat colony that was seropositive to SR-11 strain of HFRS virus (laboratory rat origin) was demonstrated in February 1983 at a dumping ground area of Kami-iso Town near Hakodate port. An HFRS-related virus, named KI-262 strain, was isolated from the lung tissue of a seropositive rat using Vero-E6 cell culture. Antigenicity of the isolate was closely related to Hantaan 76–118 and SR-11 strains by the indirect immunofluorescent antibody (IFA) test. No seropositive rat was found among the 861 rats captured in 38 other regions. It is unclear whether or not the infected rats in the positive area were introduced from abroad, though the area is located near Hakodate International Port. Furthermore, higher positive rates of urban rats in the Kami-iso area were observed in the spring and winter than in the summer and fall. Significantly high proportion of positive cases was observed among adult rats (six months or older) than among younger animals. The seasonal and age distribution of postive cases suggested that the virus was not readily transmitted from one infected rat to another. One seropostive case of a small field mouse(Clethrionomys rufocanus bedfordiae) was detected around the Kami-iso area.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01310877
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    Paper (German National Licenses)
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  • 12
    Electronic Resource
    Electronic Resource
    Lipid peroxidation caused by chinoform-ferric chelate in cultured neural retinal cells (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 1561-1563 
    Details
    ISSN: 1420-9071
    Keywords: Lipid peroxidation ; chinoform-ferric chelate ; chick neural retinal cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Incorporation of chinoform-ferric chelate was demonstrable in cultured neural retinal cells of chick embryos after 1 h of incubation, and the lipid peroxide level in the cells was increased strikingly 1 h thereafter. On the other hand, free ferric ions were scarcely incorporated into the cells, and a significant increase in the lipid peroxide level in the cells was not observed. These data indicate that chinoform is carrier of iron for its passage through cell membranes and that the incorporated iron induces lipid peroxidation which in turn leads to neural cell degeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01964807
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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