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  • 11
    Digitale Medien
    Digitale Medien
    5q- syndrome terminating in acute myeloid leukemia - Karyotype evolution and immunologic characterization of blast cells
    Amsterdam : Elsevier
    Cancer Genetics and Cytogenetics 32 (1988), S. 205-209 
    Details
    ISSN: 0165-4608
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-4608(88)90282-8
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  • 12
    Digitale Medien
    Digitale Medien
    Effects of taurine analogues on chloride channel conductance of rat skeletal muscle fibers: a structure-activity relationship investigation (1994)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 349 (1994), S. 416-421 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Skeletal muscle ; Chloride channel conductance ; Taurine binding site ; Taurine analogues ; Structure-activity relationship
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In rat skeletal muscle, taurine was proposed to interact with a low affinity binding site on sarcolemmal phospholipids near chloride channel, increasing chloride conductance (GCI). In an attempt to evaluate the structure-activity relationship between taurine and its binding site, a series of N-azacycloalkenyl analogues of taurine (A: N-(1′aza-cyclopenten-2′yl)-2-aminoethane sulfonic acid; B: N-(1′-aza-cyclopenten-2′-yl)-2-aminoethane sulfonic acid; C: N-(1′aza-cyclopenten-2′-yl)-3-amino-propane sulfonic acid; D: N-(1′aza-cyclopenten-2′-yl)-3-aminopropane sulfonic acid) have been synthetized and tested in vitro on rat extensor digitorum longus (EDL) muscle. In spite of the presence of a bulky and lipophilic 5 or 7 membered heterocycle linked to the taurine amino group, analogues A and B determined an increase of GCI, although less potently than taurine. Also 3-aminopropane sulfonic acid (homotaurine), tested in comparison, showed less activity in increasing GCI with respect to taurine, probably for the increased distance between charged groups. Taurine analogues C and D, which differ from compounds A and B for an additional methylene group, showed much lower activity in increasing GCI. It has been reported that guanidinoethane sulfonate (GES) displaces taurine from the low affinity site on sarcolemma by only 7%. This compound, characterized by lower charge density on the guanidinium cationic head, applied in vitro on EDL muscle, show reduced taurine-like activity in increasing GCl. Our results support the hypothesis that the effect of taurine on muscle GCI is due to a specific binding on a low affinity site on sarcolemma and that charge delocalization reduces the binding probability more than the substitution of the primary amino group or the increased distance between charged groups.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00170889
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  • 13
    Digitale Medien
    Digitale Medien
    Effects of taurine analogues on chloride channel conductance of rat skeletal muscle fibers: a structure-activity relationship investigation (1994)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 349 (1994), S. 416-421 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Key words: Skeletal muscle – Chloride channel conductance – Taurine binding site – Taurine analogues – Structure-activity relationship
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. In rat skeletal muscle, taurine was proposed to interact with a low affinity binding site on sarcolemmal phospholipids near chloride channel, increasing chloride conductance (GCl). In an attempt to evaluate the structure-activity relationship between taurine and its binding site, a series of N-azacycloalkenyl analogues of taurine (A: N-(1′aza-cyclohepten-2′yl)-2-aminoethane sulfonic acid; B: N-(1′-aza-cyclopenten-2′-yl)-2-aminoethane sulfonic acid; C: N-(1′aza-cyclohepten-2′-yl)-3-aminopropane sulfonic acid; D: N-(1′aza-cyclopenten-2′-yl)-3-aminopropane sulfonic acid) have been synthetized and tested in vitro on rat extensor digitorum longus (EDL) muscle. In spite of the presence of a bulky and lipophilic 5 or 7 membered heterocycle linked to the taurine amino group, analogues A and B determined an increase of GCl, although less potently than taurine. Also 3-aminopropane sulfonic acid (homotaurine), tested in comparison, showed less activity in increasing GCl with respect to taurine, probably for the increased distance between charged groups. Taurine analogues C and D, which differ from compounds A and B for an additional methylene group, showed much lower activity in increasing GCl. It has been reported that guanidinoethane sulfonate (GES) displaces taurine from the low affinity site on sarcolemma by only 7%. This compound, characterized by lower charge density on the guanidinium cationic head, applied in vitro on EDL muscle, show reduced taurine-like activity in increasing GCl. Our results support the hypothesis that the effect of taurine on muscle GCl is due to a specific binding on a low affinity site on sarcolemma and that charge delocalization reduces the binding probability more than the substitution of the primary amino group or the increased distance between charged groups.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00170889
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  • 14
    Digitale Medien
    Digitale Medien
    Antihypertensive activity of once daily metoprolol alone and with chlorthalidone and comparison with a twice daily regimen (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 209-213 
    Details
    ISSN: 1432-1041
    Schlagwort(e): metoprolol ; chlorthalidone ; essential hypertension ; treatment schedule ; side effects
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary In a multicentre, double-blind (DB), within-patient study, the antihypertensive effectiveness and tolerability of two oral administration schedules of metoprolol (M) 100 mg b.i.d. versus 200 mg once daily (o.d.), were investigated in 103 outpatients with mild to moderate essential hypertension. The study lasted 14 weeks and was divided into 3 periods: a) 2 weeks of single-blind (SB) placebo wash-out; b) 4 weeks of SB administration of M 100 mg b.i.d.; at the end of the second week of this period, chlorthalidone (C) 25 mg was added in patients with a recumbent diastolic blood pressure (BP) still 〉95 mmHg and was continued throughout the following period; and c) DB cross-over administration of M 200 mg/d for 4 weeks on a b.i.d. schedule and 4 weeks on a once daily schedule. In comparison with pretreatment values, heart rate and systolic and diastolic BP were reduced (p〈0.001) by both M administration schedules; there was no differences between the once and twice daily treatment regimens. During M once daily, betablockade was still maintained over 24 hours or longer, as the heart rate remained significantly lower than the basal value. In 57 patients, C was added at the end of the second week of SB M administration, and a further decrease in BP was observed; again, there was no significant change during once and twice daily M administration. Unwanted effects during M treatment were of minor severity, and the majority occurred when C, too, was added.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00547555
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  • 15
    Digitale Medien
    Digitale Medien
    Intermediate and long-term results after pediatric heart transplantation: incidence and role of pretransplant diagnosis (1998)
    Springer
    Transplant international 11 (1998), S. S493 
    Details
    ISSN: 1432-2277
    Schlagwort(e): Key words Pediatric heart transplantation ; Long-term follow up ; Pediatric myocarditis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract From November 1985 to 31 July 1997, 65 pediatric patients underwent heart transplantation at Bambino Gesù Hospital in Rome. Two of them underwent retransplantation, both 6 years after the first transplant. The 67 transplant patients had a mean age of 59 months; 11 were under 1 year of age. Their indications for transplantation were cardiomyopathies (38), lymphocytic myocarditis (8), and congenital heart diseases (19). Two patients of the first group successfully received a combined heart and kidney transplant. The 1-, 5-, and 11-year actuarial survival rates for the 65 patients who underwent heart transplantation were 68 %, 62 %, and 42 %, respectively. In the 1st postoperative year in patients who had had cardiomyopathy, a total of 50 episodes of acute rejection (AR), with one death, occurred (mean 1.7 AR/patient per year ± 1.5) and, in patients who had had congenital heart diseases, 19 ARs (one death) occurred with a mean of 1.58 AR/patient per year ± 1.4. The incidence of AR was significantly higher in patients who had had myocarditis with a total of 26 episodes (mean 3.7 AR/patient per year ± 2) and one death. Rehabilitation of heart transplanted children and infants was complete (NYHA class 1) in 52 % of patients of this series. We conclude that heart transplantation may give a good intermediate and long-term survival in selected patients; the extension of indications to desperately ill patients, or patients with systemic diseases or complex congenital heart diseases may bring less encouraging results, but should not be definitely excluded. Scarcity of donors remains the main limit, being still the first cause of death for patients on our waiting list. Our limited experience seems to suggest that, as described in adults, the cellular amplification of the immune response might affect the post-heart transplant follow up of pediatric patients with myocarditis resulting in a poor outcome for this population.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001470050526
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