ISSN:
1573-8221
Keywords:
cardiomyopathy
;
alcohol
;
heart
;
bioenergetics
;
lipids
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Against the background of chronic alcohol poisoning in rabbits a sharp decline is observed in the contractile power of the left ventricle, accompanied by a significant lengthening of the phases of isometric contraction and isometric relaxation. Morphological investigation of the heart revealed marked hypertrophy of the myocardium and intensification of intramyocardial lipolysis, leading to accumulation of acid lipids in the heart muscle. It may be that these lipids, requiring additional quantities of oxygen for their utilization, lead to the appearance of a state of relative hypoxia in the myocardium. Combined with the deficiency of diastole, this may lead to weakening of the contractile power of the heart and to the compensatory development of hypertrophy of the myocardium.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00834258
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