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  • 11
    Electronic Resource
    Electronic Resource
    Cell-free synthesis of 6-hydroxy-D-nicotine oxidase containing covalently bound FAD
    Amsterdam : Elsevier
    FEBS Letters 86 (1978), S. 243-246 
    Details
    ISSN: 0014-5793
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(78)80571-7
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  • 12
    Electronic Resource
    Electronic Resource
    Neutron diffraction pole figure measurements on iron meteorites
    Amsterdam : Elsevier
    Earth and Planetary Science Letters 90 (1988), S. 1-10 
    Details
    ISSN: 0012-821X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0012-821X(88)90106-9
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  • 13
    Electronic Resource
    Electronic Resource
    Determination of melatonin by high-performance liquid chromatography with electrochemical detection
    Amsterdam : Elsevier
    Journal of Chromatography A 190 (1980), S. 217-220 
    Details
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0021-9673(00)85537-5
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  • 14
    Electronic Resource
    Electronic Resource
    The crystal structure of reinhardbraunsite, Ca5(SiO4)2(OH,F)2, a new mineral of the calcio-chondrodite type (1983)
    Springer
    Mineralogy and petrology 31 (1983), S. 137-150 
    Details
    ISSN: 1438-1168
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Zusammenfassung Die Kristallstruktur von Reinhardbraunsit, Ca5(SiO4)2(OH,F)2, wurde mit Diffraktometerdaten bestimmt und bis zuR=0.033 für 1585 unabhängige Reflexe verfeinert. Reinhardbraunsit kristallisiert monoklin,P21/a, mita=11.458(2),b=5.052(1),c=8.840(1) Å, β=108.91(1)o,Z=2. Die Struktur ist der von synthetischem Calcio-Chondrodit, Ca5(SiO4)2(OH)2, sehr ähnlich. Durch den teilweisen Ersatz von OH durch F sind, das SiO4-Tetraeder ausgenommen, alle mittleren Kation-Anion- und Anion-Anion-Abstände leicht verkürzt. Ein Vergleich der Mg-, Mn- und Ca-Glieder der Chondroditgruppe zeigt eine lineare Abhängigkeit der mittleren M-O-Abstände und der Zell-Volumina von den effektiven Ionenradien. Die Verzerrungen der Kationpolyeder sind ebenfalls annähernd linear abhängig von den mittleren M-O-Abständen.
    Notes: Summary The crystal structure of reinhardbraunsite, Ca5(SiO4)2(OH,F)2, was determined from diffractometer data and refined toR=0.033 for 1585 independent reflections. Reinhardbraunsite crystallizes monoclinic,P21/a, witha=11.458(2),b=5.052(1),c=8.840(2) Å, β=108.91(1)o,Z=2. The structure is very similar to the structure of synthetic calciochondrodite, Ca5(SiO4)2(OH)2. Except of the SiO4 tetrahedron all mean cation-anion and anion-anion distances are slightly decreased due to the partial replacement of OH by F. A comparison of the Mg, Mn and Ca members of the chondrodite group shows that mean M-O distances and cell volumes are linearly related to the effective ionic radii. Polyhedral distortions are also approximately linearly related to the mean M-O distances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01084766
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  • 15
    Electronic Resource
    Electronic Resource
    The surfactant system of the adult lung: physiology and clinical perspectives (1992)
    Springer
    Journal of molecular medicine 70 (1992), S. 637-657 
    Details
    ISSN: 1432-1440
    Keywords: Pulmonary surfactant ; Phospholipids ; Surfactant proteins ; Alveolar stability ; Air pollution ; Pulmonary defense ; Adult respiratory distress syndrome ; Surfactant therapy ; Bronchoalveolar lavage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pulmonary surfactant is synthesized and secreted by alveolar type II cells and constitutes an important component of the alveolar lining fluid. It comprises a unique mixture of phospholipids and surfactant-specific proteins. More than 30 years after its first biochemical characterization, knowledge of the composition and functions of the surfactant complex has grown considerably. Its classically known role is to decrease surface tension in alveolar air spaces to a degree that facilitates adequate ventilation of the peripheral lung. More recently, other important surfactant functions have come into view. Probably most notable among these, surfactant has been demonstrated to enhance local pulmonary defense mechanisms and to modulate immune responses in the alveolar milieu. These findings have prompted interest in the role and the possible alterations of the surfactant system in a variety of lung diseases and in environmental impacts on the lung. However, only a limited number of studies investigating surfactant changes in human lung disease have hitherto been published. Preliminary results suggest that surfactant analyses, e.g., from bronchoalveolar lavage fluids, may reveal quantitative and qualitative abnormalities of the surfactant system in human lung disorders. It is hypothesized that in the future, surfactant studies may become one of our clinical tools to evaluate the activity and severity of peripheral lung diseases. In certain disorders they may also gain diagnostic significance. Further clinical studies will be necessary to investigate the potential therapeutic benefits of surfactant substitution and the usefulness of pharmacologic manipulation of the secretory activity of alveolar type II cells in pulmonary medicine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180279
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  • 16
    Electronic Resource
    Electronic Resource
    Clearanceuntersuchungen unter Khellineinwirkung (1952)
    Springer
    Journal of molecular medicine 30 (1952), S. 931-934 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01471371
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  • 17
    Electronic Resource
    Electronic Resource
    Clearance-Untersuchungen und Augenhintergrundsbefunde (1953)
    Springer
    Journal of molecular medicine 31 (1953), S. 766-768 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es wird über vergleichende Untersuchungen des Augenhintergrundes und der Clearance-Werte bei 51 Patienten mit Hochdruckund Nierenerkrankungen berichtet. Hinsichtlich des Grades der Veränderungen besteht zwischen den Befunden am Augenhintergrund und den Ergebnissen von Clearance-Untersuchungen (Nierendurchblutung, Glomerulusfiltration) häufig keine Übereinstimmung. Augenhintergrundsbefunde geben danach meist keinen zuverlässigen Hinweis auf den Grad der Veränderungen in den Nieren und sollten in dieser Beziehung klinisch nicht überbewertet werden. Abschließend wird demgegenüber der klinische Wert von Clearance-Untersuchungen betont.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01682792
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  • 18
    Electronic Resource
    Electronic Resource
    “Selbstheilende” Form eines Kollodiumbabys Transiente Verhornungsstörung oder Minimalform einer lamellären Ichthyose? (1998)
    Springer
    Monatsschrift Kinderheilkunde 146 (1998), S. 1070-1073 
    Details
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Selbstheilendes Kollodiumbaby ; Lamelläre Ichthyose ; Elektronenmikroskopie ; Key words Self-healing collodion baby ; Lamellar ichthyosis ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Collodion baby is a clinical description for a transient condition of the newborn which is caused by various disorders of cornification. The majority of cases are due to autosomal recessive lamellar ichthyosis. In up to 10% of cases „self-healing” of the skin occurs. We report about a mature male baby who at birth was covered entirely with a shining, collodion-like membrane. There also were marked ectropion of the eyelids and eversion of the lips. After shedding of the membrane almost complete clearing of the skin occurred until the age of three months. In the case reported here skin biopsies taken on the 20th day of life showed discrete and non-specific ultrastructural changes, with no features of lamellar ichthyosis or other cornification disorders. Discussion: From these findings and those reported in the literature we conclude that the prognosis of a collodion baby is unpredictable on clinical evaluation. However an ultrastructural examination can contribute to early assessment of prognosis in this heterogeneous neonatal condition.
    Notes: Zusammenfassung Das klinische Bild des Kollodiumbabys wird durch verschiedene Verhornungsstörungen hervorgerufen; in der Regel entwickelt sich später eine lamelläre Ichthyose. Eine Selbstheilung wird in bis zu 10% der Fälle beobachtet. Wir berichten über ein männliches Reifgeborenes, welches bei der Geburt vollständig in eine glänzende, kollodiumähnliche Membran gehüllt war. Weiterhin fanden sich ektropionierte Augenlider und evertierte Lippen. In den ersten Lebenswochen löste sich die Membran gänzlich ab und bis zum Alter von 3 Monaten war die Haut des Patienten weitgehend erscheinungsfrei. Die elektronenmikroskopische Untersuchung einer am 20. Lebenstag entnommenen Hautbiopsie zeigte bei unserem Patienten keinen auf eine lamelläre Ichthyose oder eine andere Verhornungsstörung hinweisenden Strukturdefekt der Keratinozyten. Es fanden sich lediglich unspezifische Veränderungen im Sinn einer Abräumreaktion. Diskussion: Unter Berücksichtigung der Literatur läßt sich folgern, daß das klinische Bild eines Kollodiumbabys keine Rückschlüsse auf den weiteren Verlauf zuläßt. Dagegen kann die Elektronenmikroskopie prognostisch richtungsweisende Aussagen beim ätiologisch heterogenen Erscheinungsbild des Kollodiumbabys erlauben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001120050367
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  • 19
    Electronic Resource
    Electronic Resource
    HLA-DR and HLA-DQ antigen expression of anagen and telogen hair bulbs in long-standing alopecia areata (1988)
    Springer
    Archives of dermatological research 280 (1988), S. 179-181 
    Details
    ISSN: 1432-069X
    Keywords: Alopecia areata ; Hair bulb epithelium ; MHC class II antigens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00456852
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  • 20
    Electronic Resource
    Electronic Resource
    Macrophages in melanocytic naevi (1992)
    Springer
    Archives of dermatological research 284 (1992), S. 127-131 
    Details
    ISSN: 1432-069X
    Keywords: Melanocytic naevi ; HLA-DR ; Langerhans cells ; Macrophages
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Whereas the inflammatory infiltrates of malignant melanoma have been widely investigated, little is known about the infiltrates accompanying benign melanocytic naevi. Using monoclonal antibodies directed against HLA-DR antigens, the CD1 antigen, the transferrin receptor and functionally divergent macrophage subpopulations, frozen fresh material of 87 melanocytic naevi (MN), ten primary cutaneous melanomas (PCM) and ten samples of normal skin were studied. Compared with normal skin, abundant HLA-DR+ cells were found in the stroma of MN equivalent to the quantity present in PCM. In MN we found higher numbers of dermal CD1+ dendritic cells compared with PCM and normal skin. There were more macrophages that expressed the transferrin receptor or the antigens 27E10, RM3/1 and 25F9 in MN than in normal skin but fewer than in PCM. No significant differences were found between congenital MN (n=40), common acquired MN (n=27) and dysplastic MN (n=20) macrophage subpopulations. Also, no correlations were evident between macrophage infiltrates and naevus location or patients' age. Our data show that potential melanoma precursors among melanocytic naevi cannot be identified by the pattern of macrophage infiltrates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00372703
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