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  • 11
    Electronic Resource
    Electronic Resource
    Induction of hepatic CYP1A activity as a biomarker for environmental exposure to Aroclor® 1254 in feral rodents (1992)
    Springer
    Archives of environmental contamination and toxicology 22 (1992), S. 339-344 
    Details
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract Specimens of the feral mouse species Reithrodontomys fulvescens trapped from a polychlorinated biphenyl (PCB)-contaminated field location had hepatic ethoxy-resorufin (ETR) O-dealkylase activities and immunoreactive CYP1A protein contents which were two- to threefold higher than those measured in animals of the same species and sex collected from non PCB-contaminated reference sites. Specimens with hepatic ETR O-dealkylase activities differing by as little as 50% could readily be assigned as originating from the PCB or reference sites by the use of a specific chemical inhibitor of cytochrome P450IA (CYP1A). The relative levels of ETR O-dealkylase activity in R. fulvescens significantly correlated with hepatic PCB burdens (r=0.819, P〈0.01). When the magnitudes of the induced ETR O-dealkylase activities corresponding to given hepatic PCB burdens were compared between the feral animals, F344/NCr rats (Rattus norvegicus) or B6C3F1 mice (Mus musculus) exposed in the laboratory to dietary Aroclor® 1254, the order of sensitivity to the inducing effects of PCBs were F344/NCr rat〉B6C3F1 mouse〉R. fulvescens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00212096
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  • 12
    Electronic Resource
    Electronic Resource
    A Computer Method for Predicting the Electrophoretic Mobility of Peptides (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 373-378 
    Details
    ISSN: 0935-6304
    Keywords: Electrophoresis ; electrophoretic mobilities ; CZE ; MEKC ; peptides ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: ---A computer model is presented for the prediction of the electrophoretic mobilities of peptides from physical constants derived from their amino acid sequences. The model assumes that the electrophoretic mobility can be represented by a product of four functions according to the relation:  lcomp= l(L)w(W)q(Q)c(CC), where L (a length parameter) is represented by the number of amino acid residues of the peptide, W (a width parameter) is represented by the average residue mass, Q = the charge of the peptide, and CC = the position of the center of charge relative to the center of mass. The model was used to calculate the electrophoretic mobilities of peptides in a 50 mM phosphate buffer at pH 2.5. Sixty-four test peptides ranging in size from 2 to 39 amino acid residues were used for this study. The calculated mobilities show excellent correlation with experimental measurements with a correlation coefficient greater than 0.98.
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 13
    Electronic Resource
    Electronic Resource
    Separation of retinoic acid isomers using micellar electrokinetic chromatography (1993)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 16 (1993), S. 560-561 
    Details
    ISSN: 0935-6304
    Keywords: Retinoic acids ; Micellar electrokinetic chromatography ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240160912
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  • 14
    Electronic Resource
    Electronic Resource
    Capillary electrophoresis separation of heterocyclic nitrosoamino acid-conformers at sub-ambient temperatures (1994)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 17 (1994), S. 753-755 
    Details
    ISSN: 0935-6304
    Keywords: Capillary electrophoresis ; Nitrosamines ; Subambient temperature ; syn and anti isomers ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The separation of a selected group of naturally occurring, heterocyclic nitrosoamino acids was achieved by capillary zone electrophoresis and the resolution of the syn and anti conformers improved as the temperature was lowered to 5 °C. The double peaks observed for each nitrosoamino acid are probably caused by the slow kinetics of conformational isomerism. The experimental setup consisted of a P/ACE 5510 electrophoresis system, a 57 cm polyacrylamidecoated capillary, and a 10 mM phosphate buffer, pH 7.2, containing 2 mM of 3-(N-N-dimethylmyristylammonio)propanesulfonate (DMMAPS) and 0.1% Tween 20. Our study shows that (a) the lower the temperature, the greater the resolution and the longer the migration times; and (b) different nitrosoamino acid conformers were resolved at different temperatures because of differences in the rate of isomerization. For example, the conformers of N-nitrosothiazolidine-4-carboxylic acid were partially resolved at 30 °C while those of N-nitrosoproline were well resolved at the same temperature.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240171104
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  • 15
    Electronic Resource
    Electronic Resource
    Determination of the purity of synthetic peptides by capillary electrophoresis, high performance liquid chromatography, and laser desorption mass spectrometry (1994)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 17 (1994), S. 102-103 
    Details
    ISSN: 0935-6304
    Keywords: HPLC ; Capillary electrophoresis (CE) ; Laser desorption mass spectrometry ; Synthetic peptides ; Purity determination ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240170213
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  • 16
    Electronic Resource
    Electronic Resource
    Separation of taxolTaxol is used in this manuscript to refer to the compound that now has the generic name paclitaxel and the registered trade name Taxol® (Bristol-Myers Squibb Company, New York, NY). and related compounds by micellar electrokinetic chromatography (1994)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 17 (1994), S. 51-52 
    Details
    ISSN: 0935-6304
    Keywords: Taxol ; Micellar electrokinetic chromatography ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240170116
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  • 17
    Electronic Resource
    Electronic Resource
    Micellar electrokinetic chromatography in coated capillaries: Determination of micelle-aqueous partition coefficients (1995)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 18 (1995), S. 171-174 
    Details
    ISSN: 0935-6304
    Keywords: Micellar electrokinetic chromatography (MEKC) ; Micelle-aqueous partition coefficients ; Hydrophobic solutes ; Polyacrylamide-coated columns ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A micellar electrokinetic chromatography method is presented for the determination of the partition coefficient for the distribution of nonpolar and moderately polar solutes between the micelle and the aqueous phases in aqueous micellar solutions. In comparison with the literature the method is, theoretically and experimentally, the most straightforward for this application. An equation is derived for the determination of the partition coefficient in a coated fused silica capillary, with neglible electroosmotic flow, from simple measurements of the migration times of solutes and a marker for micelle migration. The advantages and limitations of this method are discussed. The method is tested by using sodium dodecylsulfate (SDS) surfactant and naphthalene, benzene, toluene, and phenol solutes. Micellar electrokinetic chromatography in coated columns isideally suited for the separation of hydrophobic solutes in aqueous samples.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240180307
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  • 18
    Electronic Resource
    Electronic Resource
    Capillary electrophoresis analysis of isomeric truxillines and other high molecular weight impurities in illicit cocaine (1998)
    Weinheim : Wiley-Blackwell
    Electrophoresis 19 (1998), S. 51-56 
    Details
    ISSN: 0173-0835
    Keywords: Capillary electrophoresis ; Truxillines ; Cocaine ; Cyclodextrins ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: The analysis of by-products and impurities in illicit cocaine, including the isomeric truxillines, is important for derivation of both strategic and tactical intelligence. In the present study, various capillary electrophoresis techniques were investigated for this purpose. The use of the anionic β-cyclodextrin sulfobutyl ether IV as a run buffer additive at pH 8.6 gave a good separation of the truxillines and similar high molecular weight impurities in less than eight minutes. These impurities were first isolated from the bulk cocaine matrix using liquid-liquid extraction and size-exclusion high performance liquid chromatography. There was a red shift in the UV spectra obtained for the truxillines using photodiode array (PDA) UV detection during CE analysis. This anomalous behavior is attributed to photo-degradation of the truxillines during the PDA-UV irradiation process. Laser-induced fluorescence detection using a UV krypton/fluoride laser provided greater selectivity and sensitivity versus UV detection for certain uncharacterized high molecular weight impurities.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150190110
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  • 19
    Electronic Resource
    Electronic Resource
    Capillary electrophoresis of natural products (1997)
    Weinheim : Wiley-Blackwell
    Electrophoresis 18 (1997), S. 2438-2452 
    Details
    ISSN: 0173-0835
    Keywords: Natural products ; Capillary electrophoresis ; Micellar electrokinetic capillary chromatography ; Chinese herbal preparations ; Alkaloids ; Toxins ; Illicit drugs ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Capillary electrophoresis (CE) and micellar electrokinetic chromatography were used for the separation of widely different compounds from natural materials including antibiotics, humic substances, flavonoids, isoflavonoids, illicit drugs, coumarins, alkaloids, steroids, Chinese herbal preparations, nicotine, caffeine, amphetamines, toxins such as aflatoxins B1, B2, G1, G2, mycotoxins, heptapeptide aflatoxins and others, ephedrine compounds, mineral elements, and natural compounds in biological samples. A discussion of sample extraction and clean-up and the advantages of using CE is also presented.
    Additional Material: 25 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150181234
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  • 20
    Electronic Resource
    Electronic Resource
    Micellar electrokinetic chromatography of the anti-human immunodeficiency virus (HIV) agent michellamine B with absorption and laser-induced fluorescence detection (1994)
    Weinheim : Wiley-Blackwell
    Electrophoresis 15 (1994), S. 1310-1315 
    Details
    ISSN: 0173-0835
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Micellar electrokinetic chromatography (MEKC) was applied to the separation of the anti-HIV agents, michellamines A and B, and two other structurally related monomers found in the extract of the Ancistrocladus plants. Using buffers containing either 10 mM sodium phosphate (pH 7.0), 50 mM sodium de-oxycholate and 10-20% acetonitrile or 5 mM sodium phosphate (pH 7.0), 20 mM sodium dodecyl sulfate and 25% acetonitrile allowed baseline separations of the four components in the mixture in less than 10 min. The MEKC methods gave sharper peaks and better resolution compared to high-performance liquid chromatography. For MEKC separation of the plant extracts, UV absorption detection provided adequate sensitivity; however, higher sensitivity could be achieved with UV laser-induced fluorescence detection (LIF). Using the sodium dodecyl sulfate-containing buffer and LIF, the limit of detection for michellamine B was ∼ 2 ng/mL. The sensitivity was degraded ∼100-fold when using the deoxycholate buffer because of high background fluorescence. Preliminary results show that MEKC with LIF is feasible for the sensitive detection of michellamine B in serum.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.11501501199
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