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  • 11
    Electronic Resource
    Electronic Resource
    Die Wirkung von Tetraäthylammoniumchlorid auf die Membranströme Ranvierscher Schnürringe von Xenopus laevis (1967)
    Springer
    Pflügers Archiv 293 (1967), S. 34-55 
    Details
    ISSN: 1432-2013
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The experiments were carried out on single Ranvier nodes of Xenopus laevis. The influence of tetraethylammonium chloride (TEA) on the membrane currents was studied under voltage clamp conditions. The node under investigation was continuously superfused with the test solutions. 2. 5 mM TEA reduced the delayed currents (i.e. the potassium outward current I K and the non-specific current I p) to almost zero. The effect was fully reversible. The peak sodium current I Na and the leakage current I L were barely influenced. 3. The delayed potassium inward current seen with high external potassium concentrations was also eliminated by 5 mM TEA. 4. 0.3 mM TEA reduced I K to about two thirds of its normal value and delayed the onset of the potassium outward current. The time constant determining the change of potassium permeability was reversibly increased by a factor of 1.7. 5. The effect of TEA on the kinetics of the sodium system was comparatively small. 5 mM TEA altered the time constants for the turning on and for the inactivation of the sodium permeability by a factor of 0.9 and 1.4 respectively. 6. It was concluded that TEA mainly affects the delayed permeability increase. The described effects of TEA on the membrane currents qualitatively explain the prolongation of the action potential in TEA-treated nodes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00362660
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    Paper (German National Licenses)
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  • 12
    Electronic Resource
    Electronic Resource
    A method for electrical measurements on isolated protoplasmic droplets from Nitella (1974)
    Springer
    Pflügers Archiv 350 (1974), S. 341-346 
    Details
    ISSN: 1432-2013
    Keywords: Isolated Protoplasm ; Nitella Cells ; Excitability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A special recording chamber has been constructed which allows for the perfusion of the fragile protoplasmic droplets from Nitella cells while making electrical measurements on the preparation. Measurements were made of the potential of the interior of the droplet relative to the bathing medium, under resting conditions and during electrical stimulation. In a bathing medium whose cationic concentration resembled the natural vacuolar sap, a small resting potential of between 0 and −30 mV was observed. Stimulation with depolarizing current shocks of 100 μs in duration and of up to 0.28 mA/cm2 elicited active responses of up to 130 mV which outlasted the stimulus artifacts. The responses were graded but they resembled nerve action potentials in shape and duration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00592642
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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