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  • 11
    Electronic Resource
    Electronic Resource
    Biological Sciences: Isolation of the Cholinergic Receptor Protein of Torpedo Electric Tissue (1971)
    [s.l.] : Nature Publishing Group
    Nature 229 (1971), S. 554-557 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The electric tissue of Torpedo was chosen as a source of cholinergic receptors because of its special structure4'5 and its extraordinarily rich cholinergic innervation6'7. Each electric organ is composed of about 500 columns of electro-plaques, and each column has hundreds of cells. Judging from ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/229554a0
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  • 12
    Electronic Resource
    Electronic Resource
    Neurotrophic Control of Contracture in Slow Muscle Fibres (1968)
    [s.l.] : Nature Publishing Group
    Nature 217 (1968), S. 1274-1275 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To further investigate this problem we decided to see what would happen if the denervated iliofibularis muscle was re-innervated by a mixed nerve, containing large and small motor axons. It is known4'5 that after nerve section the large motor fibres degenerate more rapidly than the small ones, and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2171274a0
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  • 13
    Electronic Resource
    Electronic Resource
    Ionic Requirements of Synaptic Transmitter Release (1967)
    [s.l.] : Nature Publishing Group
    Nature 215 (1967), S. 651-651 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Further evidence was obtained in an experiment in which a frog sartorius muscle had been equilibrated in a "sodium-free Ringer" containing 83 mmolar calcium chloride, 2 mmolar potassium chloride, and 2xlO-6 g/ml. of neostigmine methylsulphate. When intracellular records were obtained from ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/215651a0
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  • 14
    Electronic Resource
    Electronic Resource
    Miniature Synaptic Potentials in Squid Nerve Cells (1966)
    [s.l.] : Nature Publishing Group
    Nature 212 (1966), S. 1240-1242 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1. Synaptic potentials in a nerve cell from the stellate ganglion of the squid (L. vulgaris). Intracellular potentials were recorded simultaneously from a nerve cell on the dorsal surface of the ganglion and from the giant axon in the last stellar nerve. The pre-ganglionic nerve was stimulated ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2121240a0
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  • 15
    Electronic Resource
    Electronic Resource
    Prolonged Survival of Isolated Frog Muscle and its Sensitivity to Acetylcholine (1966)
    [s.l.] : Nature Publishing Group
    Nature 209 (1966), S. 716-717 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] It has recently been shown4 that mammalian muscle can survive in organ culture, and that the fibres develop the generalized chemosensitivity even when kept in a completely synthetic medium. It was desirable to find out if similar results could be obtained from frog muscle as, for many experimental ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/209716a0
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  • 16
    Electronic Resource
    Electronic Resource
    Effect of a ‘Fast’ Nerve on ‘Slow’ Muscle Fibres in the Frog (1966)
    [s.l.] : Nature Publishing Group
    Nature 209 (1966), S. 717-718 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The question arises whether the different characteristics are imposed on the muscle fibres by the type of nerve fibre they receive. Buller, Eccles and Eccles4 have already shown that the contractions of slow and fast mammalian muscles alterr when their fibres are cross-innervated with nerves of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/209717a0
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  • 17
    Electronic Resource
    Electronic Resource
    Input–Output Relation of a Single Synapse (1966)
    [s.l.] : Nature Publishing Group
    Nature 212 (1966), S. 1242-1245 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The main results, illustrated in Figs. 1 and 2, were obtained by placing two microelectrodes into the presynaptic fibre (one for passing current, and the other for recording membrane potential), and one recording electrode into the postsynaptic axon. The region of synaptic contact extended over a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2121242a0
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  • 18
    Electronic Resource
    Electronic Resource
    Release of Acetylcholine from a Nerve Terminal by Electric Pulses of Variable Strength and Duration (1965)
    [s.l.] : Nature Publishing Group
    Nature 207 (1965), S. 1097-1098 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1. End-plate potentials recorded with intracellular electrode from frog muscle paralysed with tetrode-toxin. Temperature 7 C. Depolarizing pulses applied directly to nerve terminal. Pulse strength indicated in bottom trace of each column. Pulse duration 0-5 msec. Left column: weak current. The ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2071097a0
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  • 19
    Electronic Resource
    Electronic Resource
    Subunit-selective modulation of GABAA receptors by the non-steroidal anti-inflammatory agent, mefenamic acid (1999)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 11 (1999), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Mefenamic acid (MFA) has anti-convulsant and pro-convulsant effects in vivo, and has been shown to potentiate and inhibit GABAA (γ-aminobutyric acid) receptors in vitro. In this study, whole-cell currents were recorded from Xenopus oocytes and human embryonic kidney (HEK) cells expressing human recombinant GABAA receptors to resolve the molecular mechanisms by which MFA modulates GABAA receptor function. We demonstrate that MFA potentiated GABA-activated currents for α1β2 γ2S (EC50 = 3.2 ± 0.5 μm), but not for α1β1 γ2S receptors. MFA also enhanced GABA-activated responses and directly activated α1β2/β3 GABAA receptors, but inhibited responses to GABA on α1β1 constructs (IC50 = 40 ± 7.2 μm). A comparison of β1, β2 and β3 subunits suggested that the positive modulatory action of MFA involved asparagine (N) 290 in the second transmembrane domain (TM2) of the β2 and β3 subunits. Mutation of N290 to serine (S) markedly reduced modulation by MFA in α1β2(N290S)γ2S receptors, whereas α1β1(S290N)γ2S constructs revealed potentiated responses to GABA (EC50 = 7.8 ± 1.7 μm) and direct activation by MFA. The potentiation by MFA displayed voltage sensitivity. The direct activation, potentiation and inhibitory aspects of MFA action were predominantly conferred by the β subunits as the spontaneously active homomeric β1 and β3 receptors were susceptible to modulation by MFA. Molecular comparisons of MFA, loreclezole and etomidate, agents which exhibit similar selectivity for GABAA receptors, revealed their ability to adopt similar structural conformations. This study indicates that N290 in TM2 of β2 and β3 subunits is important for the regulation of GABAA receptor function by MFA. Our data provide a potential molecular mechanism for the complex central effects of MFA in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.1999.00709.x
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  • 20
    Electronic Resource
    Electronic Resource
    Changes in messenger RNAs coding for neurotransmitter receptors and voltage-operated channels in the developing rat cerebral cortex
    Amsterdam : Elsevier
    Developmental Biology 138 (1990), S. 313-323 
    Details
    ISSN: 0012-1606
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0012-1606(90)90199-S
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