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  • 11
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 13 (1986), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The response of plasma levels of active and inactive renin to haemorrhage was investigated in sheep with indwelling artery and vein catheters.2. In conscious animals, loss of 10% of estimated blood volume over a 5 min period increased plasma active renin by a mean of 59%, a surprisingly small change. Plasma inactive renin also increased, but only by 86%. Maximum increases in both forms of renin occurred within 1 h of the haemorrhage.3. The effects of an equivalent blood loss were investigated in pentobarbitone-anaesthetized sheep maintained in an upright posture using padded slings. Anaesthesia per se had no effect on plasma active or inactive renin. In anaesthetized sheep, 3 h after haemorrhage, plasma active renin had increased by 403% and inactive renin by 299% above control values, but a plateau (maximum) response was not reached during this time.4. In both conscious and anaesthetized animals the haemorrhage-induced increases in active and inactive renin occurred in parallel.5. It appears that haemorrhage of this intensity is a comparatively mild stimulus to increase plasma renin concentration in conscious sheep but is much more effective in anaesthetized animals. This may be linked to anaesthetic-induced increases in prostaglandin synthesis within the kidney.
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 13 (1986), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Regulation of plasma active and inactive renin was investigated using conscious sheep with indwelling artery, vein and bladder catheters. Control and experimental studies were carried out in the same animals on different days.2. The calcium antagonist drug verapamil was given as an initial bolus injection (0.5 mg/kg) followed by a continuous infusion (0.1 mg/kg per h) over a 2.5 h period.3. Plasma active and inactive renin changed in parallel. Both were significantly increased within 15 min of the initial drug dose and both attained a peak increase after 45 min. Thereafter, the two forms of renin returned to basal levels despite continued infusion of the drug.4. Effective renal plasma flow (CPAH) was also transiently increased by verapamil and followed a similar time course to changes in plasma active and inactive renin concentration. Arterial blood pressure, however, remained suppressed by verapamil for the duration of the study.5. Verapamil did not alter urine flow or sodium and potassium excretion rates.6. These results are discussed in relation to the possible link between intrarenal haemodynamics and renin secretion in conscious and in anaesthetized animals and also in relation to the concept that variation in the relative amounts of active and inactive renin secreted in differing physiological situations represents a mechanism for regulating the renin-angiotensin system.
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 34 (2004), S. 0 
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Chronic inflammation in asthmatic airways can lead to characteristic airway smooth muscle (ASM) thickening and pathological changes within the airway wall.Objective We investigated the long-term effects of repeated allergen exposure.Methods Brown-Norway (BN) rats sensitized to ovalbumin (OVA) were exposed to OVA or saline aerosol every third day on six occasions and studied 24 h, 7 days and 35 days after the final exposure. We measured airway inflammation, ASM cell proliferation (by incorporation of bromodeoxyuridine; BrdU) and bronchial responsiveness to acetylcholine.Results At 24 h, in OVA-exposed rats, we detected elevated OVA-specific serum IgE, increased numbers of macrophages, eosinophils, lymphocytes and neutrophils in the bronchoalveolar lavage (BAL) fluid and increased numbers of MBP+ (major basic protein) eosinophils and CD2+ T cells within the bronchial submucosa. This coincided with increased numbers of ASM cells expressing BrdU and with bronchial hyper-responsiveness (BHR). At 7 days, BHR was detected in OVA-exposed rats, coincident with increased numbers of macrophages and lymphocytes in BAL fluid together with increased numbers of CD2+ T cells within the bronchial submucosa. This coincided with increased numbers of ASM cells expressing BrdU. By day 35, the number of ASM cells expressing BrdU remained elevated in the absence of cellular infiltration and BHR.Conclusion Repeated OVA-challenge results in persistent ASM cell proliferation in the absence of bronchial inflammation and BHR, which lasts for at least 1 week following cessation of exposure.
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    European journal of soil science 51 (2000), S. 0 
    ISSN: 1365-2389
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Soil acidification and related land degradation are becoming more important worldwide and are challenging the concept of sustainability of current land management systems. We have studied the impact on soil properties of two management systems, one in a tropical savanna, the other in a humid subtropical environment, particularly in relation to their cation chemistry. In Northeast Thailand the properties of an Acrisol cleared of dipterocarp forest some 37 years previously and used for continuous crop production are compared with adjacent undisturbed forest. In southern Queensland, Australia, the properties of a Luvisol used for intensive pasture production for 36 years are compared with those prior to introduction of the management system. Under both regimes, the soil pH fell by about 1 unit, with an increase in aluminium saturation of the cation exchange complex. Organic carbon in the Acrisol greatly decreased, but in the Luvisol it increased significantly. Consequently, the effects on surface charge characteristics were strikingly different, in that the Acrisol had been almost irreversibly degraded, whereas acidification and base diminution in the Luvisol can be easily reversed through conventional management. The amount of degradation caused by each management system has been quantified in terms of a Saturation Index, Su: S u = 100 × (Cu5.5 − Σ)/Cu5.5,where Cu5.5 refers to the cation exchange capacity on the undisturbed (forested) site and Σ is the sum of the base cations at field pH. This index encompasses an assessment of the degree of degradation taking into account the previous land use, in this case forest, and that due to anthropogenic disturbance. For the Queensland Luvisol Su does not change, because the pasture management has not appreciably altered the CEC at pH 5.5. However, for the Thailand site Su increased from 0 to 86%. Consequently in its present state, the surface horizon of this cultivated soil can retain only about 15% of the basic cations it could ideally hold under undisturbed conditions.
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    European journal of soil science 46 (1995), S. 0 
    ISSN: 1365-2389
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Acidity in the soil surface and subsurface is of major concern in horticulture, cropping and pasture production systems in southern Australia. Broadcast applications of lime to the surface have proved to be ineffective in ameliorating subsurface acidity in the short term. Two calcium-saturated coal-derived organic products, an ‘oxi-product’ (OXPR) and an ‘oxi-fulvate’ (OXFU), were evaluated for use as liming materials with specific consideration given to amelioration of subsurface acidity. The effects of these two organic products and of lime on the chemical composition of the A1 and A2 horizons of an acid red podzol were investigated in leaching columns, 20 cm long. OXPR and OXFU supplying 80 or 160 g Ca m−2 were compared to 160 g Ca m−2 applied as CaCO3 and a control receiving no amendments. The effects of CaCO3 on exchangeable Al and pH were limited to the surface 2 cm. In contrast, the two organic amendments were effective in decreasing exchangeable Al and increasing pH and exchangeable Ca to depth, the extent being a function of amendment and rate applied. The formation of inorganic and organic complexes were assumed to be responsible for the movement of Al out of the column in the leachate, although significant quantities of Al were precipitated in the column. Significant linear regressions were observed between the ionic strength and Al in the leachate. Significant quantities of Mg and K were displaced by Ca and leached from the column; consequently, this loss must be considered against the benefits of decreased exchangeable Al when assessing fertility for plant production.
    Type of Medium: Electronic Resource
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  • 16
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 65 (1994), S. 3042-3043 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We report a bakeable vacuum seal between glass blanks and a stainless-steel conflat vacuum port without leaks at the 10−10 atm cm3 s−1 level. The seal permits true optical windows, both flat and coated, to be economically used in ultrahigh-vacuum applications
    Type of Medium: Electronic Resource
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  • 17
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 77 (1970), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A double-blind study was made comparing pethidine 150 mg. with phenazocine (Narphen) 3 mg. for relief of pain in labour. In these doses neither pethidine nor phenazocine gave consistently effective analgesia.Phenazocine was less effective as an analgesia but had a lower incidence of side effects and fetal depression. It was concluded that the doses chosen were not equivalent.
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 77 (1970), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Out of 180 patients who had a myomectomy at the Chelsea Hospital for Women between 1954 and 1962, 116 were followed for more than one year. One in four of these patients had a subsequent hysterectomy and about one in three conceived after surgery. Of the patients known to have conceived only three out of four carried pregnancies beyond 28 weeks. Myomectomy did not seem to alter the high incidence of abortions and perinatal deaths in patients found to have fibromyomata. Pregnancies occurring after myomectomy required close specialist supervision and often ended in Caesarean section.
    Type of Medium: Electronic Resource
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  • 19
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 88 (1981), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Reversal of sterilization was attempted in 22 women without the use of an operating microscope. Fifty per cent became pregnant. Success was influenced by the site and extent of the tubal damage resulting from the sterilization procedure, mechanical occlusive sterilization techniques offering the best change of a successful reversal.
    Type of Medium: Electronic Resource
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  • 20
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 86 (1979), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 27-year-old patient who became pregnant whilst fitted with an intrauterine contraceptive device developed an intrauterine Candida albicans infection and aborted. The diagnostic (and other inconspicuous) features of C. Albicans infection in the fetus are described. The presence of the intrauterine contraceptive device may have predisposed to the establishment of the infection.
    Type of Medium: Electronic Resource
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