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  • 11
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 23 (1993), S. 0 
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Cetirizine is a potent, selective H1 histamine receptor antagonist. The effect of oral and inhaled eetirizine was assessed on the early bronchoconstrictor response to inhaled allergen in 10 mild atopie asthmatic patients in a double-blind, randomized, plaeebo controlled trial. All were sensitive to Dermatophagoides pleronyssinus and this was used as the provoking allergen. The geometric mean PD20 FEV] values obtained at allergen challenge were measured as cumulative breath units (c.b.u.) and following oral cetirizine, inhaled cetirizine and placebo were 124–5, 75–7 and 76–7 c.b.u. respectively. These did not differ significantly. We conclude that neither oral nor inhaled cetirizine significantly attenuates the early response to inhaled allergen in atopie asthmatic subjects. However, the method of repeated allergen challenge is likely to be relatively insensitive. Clinical and Experimental Allergy, [o]. 23, pp. 528–531.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 12
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 14 (1984), S. 0 
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The effect of increasing concentrations of inhaled sodium cromoglycate (SCG) (2, 10, 20 and 40 g/l) on histamine and methacholine bronchial reactivity was studied in nine patients with extrinsic bronchial asthma. The responses to histamine and methacholine were expressed in terms of provocative concentrations producing 20% fall in the FEV1 (PC20)- The PC20 for histamine and methacholine was unaffected by all the concentrations of SCG used in the study. These results suggest that the effect of SCG on the bronchial smooth muscle or on the muscarinic receptors is minimal.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 13
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 11 (1981), S. 0 
    ISSN: 1365-2222
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: A pulmonary survey was undertaken in a large granary in the West of Scotland. The lung functions and respiratory symptoms were compared in nineteen atopic and fifty-six non-atopic grain handlers with reference to their smoking habits and also to forty-eight control subjects with no previous exposure to grain dust. Cigarette smokers from the granary workers and the control group had more respiratory symptoms and significantly lower PF, FEV1, V25 and V50. The atopic grain handlers, on the other hand, had better ventilatory functions compared to non-atopic workers. This difference in the atopic group may be related to their lower cigarette consumption, shorter service in the granary or the process of self selection. The grain handlers with wheeze or breathlessness at work had significantly higher incidence of restrictive type MEFV curves and this could not be attributed to increased cigarette consumption, atopy or longer duration of employment and there was no correlation between severity of symptoms and occupational exposure. Although PF, FEV1, FVC, V25, V50 and V75failed to show significant differences in granary workers and controls, the shape of MEFV curve may have significance as a sensitive indicator of the effect of grain dust as a preclinical stage.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 14
    ISSN: 1436-5073
    Schlagwort(e): molybdenum ; AAS ; solvent extraction of Mo
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract A selective and sensitive method for the extraction and microgram determination of molybdenum (VI) with hydroxamic acid as yellow molybdenum-hydroxamate complex from acidic medium is described. The molybdenum-PCPPSAHA complex has λmax 388 nm, molar absorptivity 5.0 × 103l mol−1 cm−1. The system obeys Beer's law in the range of 1–28 μg/ml of molybdenum(VI). Sandell's sensitivity is 0.0192 μg cm2 and stoichiometry of the complex is 1∶2, molybdenum: PCPPSAHA while mixed complex molybdenum-PCPPSAHA-morin has λmax 400 nm and molar absorptivity 5.9 × 103lmo1−1 cm−1 and stoichiometry of the complex is 1∶2∶1. The molybdenum is determined by graphite furnace atomic absorption spectrophotometry after directly pipetted the extract into the furnace which increases the sensitivity 20 fold.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 15
    Digitale Medien
    Digitale Medien
    Springer
    Histochemistry and cell biology 69 (1980), S. 101-109 
    ISSN: 1432-119X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Cytochemical detection of ascorbic acid in cultured root tips of Zea mays shows that dividing cells accumulate ascorbic acid in the cytoplasm. The localization pattern alters in the root tip as the cells begin to elongate. In elongating cells ascorbic acid is distinctly localized on cell walls. Ascorbic acid content per cell inreases with the onset of cell elongation. Fully elongated cells contain fivefold more ascorbic acid than meristematic cells. Cytophotometric analysis reveals a sharp and positive correlation (r=+0.93) between percentage increase in content of ascorbic acid per cell and corresponding increase in cell size at different phases of cell elongation. IAA treatment to the roots raises the content of ascorbic acid per cell with a parallel increase in size of cell. Involvement of ascorbic acid in IAA induced cell elongation is discussed.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 16
    Digitale Medien
    Digitale Medien
    Springer
    Medical & biological engineering & computing 26 (1988), S. 628-632 
    ISSN: 1741-0444
    Schlagwort(e): Airway model ; In vivo air temperature ; Respiratory convective heat transfer ; Respiratory heat loss
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract Airway cooling and drying has been proposed as a mechanism of exercise-induced asthma. Of interest in understanding the role of respiratory heat loss are the airway zones enduring the principal cooling and drying stresses. We have compared the axial rise in air temperature in the upper respiratory tract of asthmatics with that occurring in a laminar airflow steady-state model of convective heat transfer. The latter allowed an assessment of the contribution of airway geometry to the overall air warming process and gave some indication of the likely in vivo air temperature during hyperventilation, which due to the nature of our patients we could not measure directly. In vivo measurements were performed during a fibre-optic bronchoscopy. Eleven patients (67 years ±0·76) inhaled ambient air (23·2°C) and cold air (−17·5°C) nasally at a ventilation of 10 l min−1. During cold air inhalation the air temperature of the pharynx was 32·7°C (1·0) and at the third-generation bronchi 37°C (0·5), whereas with ambient air these were 35·8°C (0·8) and 37·7°C (0·6), respectively. For the same inspired ambient air condition the corresponding air temperatures in the thermodynamic model were approximately 27°C and 32°C. The axial rise in air temperature in both the model and in vivo state were characterised by a rapid early warming phase regardless of airflow rate. We conclude that the region proximal to the pharynx will endure the most severe cooling during a hyperventilation challenge.
    Materialart: Digitale Medien
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