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  • 11
    Electronic Resource
    Electronic Resource
    Properties and genetic control of four methyltransferases involved in methylation of anthocyanins in flowers of Petunia hybrida (1984)
    Springer
    Planta 160 (1984), S. 174-179 
    Details
    ISSN: 1432-2048
    Keywords: Anthocyanin biosynthesis ; Anthocyanin-3′,5′-methyltransferase ; Petunia (anthocyanin)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Four S-adenosyl-l-methionine:anthocyanin-3′,5′-O-methyltransferases in flowers of Petunia hybrida were separated using the chromatofocusing technique. Each methyltransferase is controlled by one of the methylation genes Mt1, Mt2, Mf1 or Mf2. Molecular weight, pH-activity optimum, isoelectric point, several kinetic properties and the behaviour in the presence of Mg2+, ethylenediaminetetraacetic acid and S-adenosyl-l-homocysteine of each of the four enzymes were determined. The methylation in vitro of delphinidin 3-(p-coumaroyl)-rutinosido-5-glucoside reflected the accumulation patterns of methylated anthocyanins in vivo and established the regulatory role of methyltransferases in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00392867
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  • 12
    Electronic Resource
    Electronic Resource
    Duplications of mitochondrial DNA: Implications for pathogenesis (1992)
    Springer
    Journal of inherited metabolic disease 15 (1992), S. 487-498 
    Details
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This paper describes the mapping data obtained on two patients in whom there was clear evidence for a rearrangement of mitochondrial DNA, using restriction enzyme analysis of DNA from whole blood and of polymerase chain reaction products. This suggested that a direct tandem duplication was present, and this was confirmed by sequence analysis of the junction fragment between duplicated segments. In each case the gene for cytochrome oxidase subunit I (MTCOX1) was interrupted, creating reading frames which, if transcribed and translated, would result in truncated versions of this peptide. Heteroplasmy and mosaicism for the abnormal mtDNA population were apparent. Preliminary data also suggest that high-molecular-weight rearrangements of the duplicated region are present in all tissues. The hypothesis that these duplicated genomes caused the phenotype was investigated by examining the distribution of duplicated genomes in various tissues using Southern hybridization and by RNA analysis. This included Northern blotting and cDNA sequencing. In order to investigate the origins of the duplicated mtDNAs, their distribution in different cells within a tissue was documented using the polymerase chain reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01799607
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    Paper (German National Licenses)
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  • 13
    Electronic Resource
    Electronic Resource
    Functional mtDNA replication defect in a fibroblast line from a patient with mtDNA depletion (1996)
    Springer
    Journal of inherited metabolic disease 19 (1996), S. 123-126 
    Details
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01799409
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  • 14
    Electronic Resource
    Electronic Resource
    Variation in mitochondrial DNA levels in muscle from normal controls. Is depletion of mtDNA in patients with mitochondrial myopathy a distinct clinical syndrome? (1995)
    Springer
    Journal of inherited metabolic disease 18 (1995), S. 4-20 
    Details
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent studies have identified a group of patients with cytochrome oxidase (COX) deficiency presenting in infancy associated with a deficiency of mtDNA in muscle or other affected tissue (Moraes et al 1991). We used a novel approach to compare the level of mitochondrial (mtDNA) compared to nuclear DNA in skeletal muscle from a group of patients and controls, based on dot blots that were hybridized with a mtDNA probe labelled with35S[dCTP] and a reference nuclear DNA probe labelled with [32P]dCTP. The ratio of mtDNA to nuclear DNA varied in samples from different muscles of the same individual. Secondly, fetal muscle had very low levels of mtDNA compared to nuclear DNA, and data from older controls (cross-sectional rather than sequential) suggest that this increases rapidly over the first 3 months after birth and thereafter more slowly. Four patients with COX deficiency had levels of mtDNA that were below the age-specific range defined by ‘normal’ quadriceps muscle. The clinical features of two of these patients were similar to earlier case reports of mtDNA depletion. In three patients the clinical course was relatively benign compared to cases that have previously been described. Levels of mtDNA in skeletal muscle from some patients with other forms of muscle disease were also found to be low, suggesting that mtDNA depletion, possibly related to depletion of mitochondria, may be a relatively non-specific response of muscle to various pathological processes. However, there does appear to be a distinctive group of young patients with reduced cytochrome oxidase activity in muscle, in whom marked mtDNA depletion reflects the primary defect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00711367
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  • 15
    Electronic Resource
    Electronic Resource
    Corynebacterial infection of cattle in Kenya (1982)
    Springer
    Tropical animal health and production 14 (1982), S. 33-36 
    Details
    ISSN: 1573-7438
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Des infections cutanées du bétail causées parCorynebacterium ovis, soit en tant que germe pathogène dominant soit en association avec d'autres organismes ont eté constatées dans un ranch du Kenya. Le taux de morbidité a été de 25 p.100 environ pour plus de 3 000 animaux, et cette maladie est apparue extrêmement infectieuse. Trois traitements ont été institués, le plus satisfaisant consistant dans la ponction des abcès les plus importants et leur lavage par irrigation avec une solution iodée.
    Abstract: Resumen Se investigaron en un rancho de Kenia, infecciones de la piel causadas porCorynebacterium ovis como principal patógeo o en asociación con otros organismos. La tasa de morbilidad fué de aproximadamente 25% siendo la condición altamente contagiosa. Se instituyeron tres tratamientos siendo el más efectivo la ruptura de los abscesos y su irrigación con una solución yódica.
    Notes: Summary Skin infections in cattle caused by Corynebacterium ovis, either as the main pathogen or in association with other organisms, was investigated on a Kenya ranch. The morbidity rate was approximately 25% involving more than 3,000 cattle and the condition appeared to be highly infectious. Three treatment regimes were instituted and the most effective proved to be lancing and irrigating the large abscesses with iodine solution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02281102
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    Paper (German National Licenses)
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