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  • 11
    Electronic Resource
    Electronic Resource
    Osteopetrorickets: case report (2000)
    Springer
    European journal of pediatrics 159 (2000), S. 579-581 
    Details
    ISSN: 1432-1076
    Keywords: Key words Osteopetrosis ; Rickets
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report the case of a baby girl who presented with rickets at 3 months. At the age of 5 months she was readmitted because of nystagmus and a diagnosis of osteopetrosis was made on the basis of clinical and radiological findings. Rickets is a paradoxical feature of osteopetrosis resulting from inability to maintain a normal calcium-phosphorus balance. In our patient the onset of rickets before other symptoms of osteopetrosis suggests a primary defect. Conclusion It is possible that patients with osteopetrosis and rickets (osteopetrorickets) represent a different mutation like the osteopetrosis mouse, which is the only animal mutation with rickets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310000485
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  • 12
    Electronic Resource
    Electronic Resource
    Unoccupied electronic structure of phthalocyanine films (1990)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 93 (1990), S. 6859-6864 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The unoccupied molecular orbitals of metal-free phthalocyanine (H2PC), nickel-phthalocyanine (NiPC), and copper-phthalocyanine (CuPC) adsorbed on single crystal surfaces have been studied by inverse photoemission spectroscopy (IPES) and near-edge x-ray absorption spectroscopy (NEXAFS). The features observed in the experimental data are assigned by reference to molecular orbital calculations. Carbon and nitrogen 1s NEXAFS measurements of NiPC adsorbed on Cu(110) surface indicates that the phthalocyanine molecular planes are parallel to the surface. X-ray absorption data recorded at the Ni LIII and LII edges show that the unoccupied Ni 3d level is located in the plane of the phthalocyanine rings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.458918
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  • 13
    Electronic Resource
    Electronic Resource
    Core-electron excitations and the electronic decay of core-to-bound-state transitions in condensed azabenzenes (1989)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 91 (1989), S. 20-28 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We have measured N 1s near edge absorption spectra and the kinetic energy distribution of electrons emitted in the decay of N 1s core-to-bound-state excitations in condensed pyridine, pyrazine, and s-triazine. The electron emission spectra generated in the electronic decay of the core to bound state resonances lead to singly charged, participator-type molecular final states, equivalent to the final states populated in photoemission, as well as to double hole (Auger) spectator-type final states screened by the presence of a π spectator electron. The deexcitation spectra, therefore, give insight into charge–transfer and screening processes in the initial core-electron excited state, as well as in the final spectator double-hole states. One of the most prominent participator features observed in the spectra of pyridine, pyrazine, and s-triazine is due to the emission of the most strongly bound π electrons, reflecting the dynamic screening of the core hole in the aromatic azabenzene molecules. The spectator states, on the other hand, exhibit a much reduced screening energy shift compared to linear molecules due to the delocalized nature of the π spectator electron.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.457507
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  • 14
    Electronic Resource
    Electronic Resource
    Platinum in the environment: frequency of reactions to platinum-group elements in patients with dermatitis and urticaria (2000)
    Copenhagen : Munksgaard International Publishers
    Contact dermatitis 43 (2000), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of the present paper is to evaluate whether increasing environmental exposure increases the frequency of the positive prick and patch test reactions to certain chlorinated platinum salts in patients with dermatitis and urticaria. 800 consecutive subjects with contact dermatitis (n=749) and urticaria (n=51) were variously patch and prick tested with 30 haptens of a standard series, with aqueous solutions of, respectively, hexachloroplatinic acid (H2[PtCl6]), potassium tetrachloroplatinate (K2[PtCl4]), sodium hexachloroplatinate (Na2[PtCl6]), iridium chloride (IrCl3), rhodium chloride (RhCl3) and palladium chloride (PdCl2), and with 16 common inhalants. 153 workers, variably exposed in a platinum refinery, were patch and prick tested only with solutions containing platinum-group elements at various concentrations and with 16 common inhalants. Platinum-group elements did not elicit positive patch or prick test reactions in non-occupationally exposed subjects. In contrast, in exposed workers, positive patch test reactions at day 2 and at 25 min, respectively, were found in 2 subjects with hand dermatitis and in 2 with urticaria and asthma. 22 out of the 153 workers, 18 of whom had rhinitis, asthma, and urticaria, gave positive prick test reactions to 1 or more salts. Furthermore, on patch and prick testing, 4 cross-reactions between platinum, palladium, iridium and rhodium were demonstrated. In conclusion, the test results demonstrate that the present concentration in the environment does not increase the incidence of reactions to platinum salts in patients with dermatitis and/or urticaria. However, if the average level of environmental platinum exposure approaches those existing in industrial settings in the future, we are going to observe more frequent health effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0536.2000.043006333.x
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  • 15
    Electronic Resource
    Electronic Resource
    Interaction retinol-chromatin: an analysis of DNA from vitamin A-treated V79 Chinese hamster cells
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Gene Structure and Expression 1007 (1989), S. 30-35 
    Details
    ISSN: 0167-4781
    Keywords: (V79 Chinese hamster cell line) ; Chromatin-retinol interaction ; DNA ; Vitamin A
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0167-4781(89)90126-7
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  • 16
    Electronic Resource
    Electronic Resource
    Nevoid Basal Cell Carcinoma Syndrome in infants: improving diagnosis (2005)
    Oxford, UK : Blackwell Science Ltd
    Child 31 (2005), S. 0 
    Details
    ISSN: 1365-2214
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Background  Diagnosis of Nevoid Basal Cell Carcinoma Syndrome (NBCCS) in infants may pose significant challenges to clinicians owing to its variable expressivity and age-related manifestations.Methods  We report two paediatric cases of NBCCS who presented initially with a non-specific phenotype.Results  In case 1, a diagnosis of NBCCS was possible only after the father was interviewed and found to present with two major criteria for the disease. Subsequent molecular testing confirmed the diagnosis. In case 2, molecular testing of the infant and his father had diagnostic value as neither satisfied fully the current diagnostic criteria for NBCCS.Conclusions  Presence of the few clinical manifestations of NBCCS that appear in infants, typically congenital malformations and skeletal abnormalities, should prompt clinicians to conduct in-person interviews with both parents. In general, paediatricians should refer both parents of infants who are suspected of having an inherited condition to clinical geneticists for expert examination, given the potential unreliability of reported medical history.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2214.2005.00514.x
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  • 17
    Electronic Resource
    Electronic Resource
    Conformational state of circulating human plasma fibronectin
    Amsterdam : Elsevier
    FEBS Letters 178 (1984), S. 327-330 
    Details
    ISSN: 0014-5793
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(84)80627-4
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  • 18
    Electronic Resource
    Electronic Resource
    Occupational hypersensitivity to metal salts, including platinum, in the secondary industry (2005)
    Oxford, UK : Munksgaard International Publishers
    Allergy 60 (2005), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Exposure to platinum group elements (PGEs) – platinum (Pt), palladium (Pd), rhodium (Rh) and iridium (Ir) – may cause acute toxicity or hypersensitivity with respiratory symptoms, urticaria and (less frequently) contact dermatitis. Our aim was to determine the prevalence and the clinical characteristics of hypersensitivity to platinum salts and to other elements of the platinum group.Methods:  A total of 153 subjects working in a catalyst manufacturing and recycling factory were examined. The examination consisted of a work exposure and medical questionnaire, physical examination, skin prick test for PGEs and other common aeroallergens, and patch tests for PGEs. Skin prick tests and patch tests were performed with H2[PtCl6], K2[PtCl4], Na2[PtCl6], IrCl3, RhCl3, PdCl2, aqueous solutions at different concentrations.Results:  Positive prick test reactions to Pt-salts at various concentrations were found in 22 (14.4%) of 153 workers; eight had simultaneous reactions to all Pt-salts tested; seven had positive responses to H2[PtCl6] only; four had simultaneous positive reactions to both H2[PtCl6] and K2[PtCl4]; three had positive reactions to H2[PtCl6] and Na2[PtCl6]. Three of 22 had positive reactions to H2[PtCl6] and IrCl3 solutions, two of these had positive reactions to H2[PtCl6], IrCl3 and RhCl3 solutions. Positive patch test reactions to platinum salts at day 2 were seen in two of 153 subjects.Conclusions:  The results of this study demonstrate that Pt-salts are important allergens in the catalyst industry and that the clinical manifestations involve both the respiratory system and the skin. Hexachloroplatinic acid should be considered the most important salt to use for skin prick tests.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.2004.00521.x
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  • 19
    Electronic Resource
    Electronic Resource
    Cutaneous response to irritants (2003)
    Oxford, UK : Munksgaard International Publishers
    Contact dermatitis 48 (2003), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We evaluated the role of pre-existing dermatitis in the response to irritants by patch testing the skin of 40 healthy volunteers and the uninvolved skin of 480 subjects for 2 days. These latter were affected by active atopic dermatitis, psoriasis, eczema with positive and negative patch test reactions, urticaria and generalized pruritus. A first panel containing 15 µL of aq. solutions of disodium laureth sulfosuccinate (NaLSS) 5% and 10%, potassium cocoate (KCC) 5%, potassium oleate (KOL) 5%, zinc coleth sulphate (ZnCS) 5%, sodium mireth sulphate (NaMS) 5%, sodium cocoamphoacetate (NaCCAA) 3% and 5%, was simultaneously applied to 1 site on the upper back. The results, scored by visual assessment, were compared to those observed when testing on the opposite side a second panel containing 15 µL of aq. solutions of 3 well-known irritants, benzalkonium chloride (BAK) 1%, sodium lauryl sulphate (SLS) 1%, and dimethylsulphoxide (DMSO) 10%. Whilst the substances of the first panel and DMSO gave, on the whole, a scarce number of positive responses in all the tested groups, more evident differences in number, percent and mean intensity of the positive responses to BAK and SLS were found between the different groups. Although some of them seemed statistically significant, when the same values were evaluated by means of χ2 and Student t-test, they did not differ in a statistically significant way from the values found in healthy subjects. The results of this study seem to indicate that the substances of the first panel have a chemical structure that makes them quite safe in real-life conditions. In contrast, BAK and SLS have chemical properties that condition the number and intensity of the responses, making the role exerted by the pre-existing dermatosis quite marginal. In particular, there is no proof that the healthy skin of active atopic subjects is the most susceptible to the irritating effects of the tested substances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0536.2003.480203.x
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  • 20
    Electronic Resource
    Electronic Resource
    Genetic damage via alkylation of DNA precursor pool
    Amsterdam : Elsevier
    Cell Biology International Reports 10 (1986), S. 489 
    Details
    ISSN: 0309-1651
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0309-1651(86)90064-0
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