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  • 11
    Electronic Resource
    Electronic Resource
    Synthesis of new thiazinoindole derivatives and their evaluation as inhibitors of human leukocyte elastase and other related serine proteases
    Amsterdam : Elsevier
    Bioorganic & Medicinal Chemistry Letters 4 (1994), S. 2399-2404 
    Details
    ISSN: 0960-894X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0960-894X(01)80398-X
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  • 12
    Electronic Resource
    Electronic Resource
    Ito formula forC 1-functions of semimartingales (1996)
    Springer
    Probability theory and related fields 104 (1996), S. 27-41 
    Details
    ISSN: 1432-2064
    Keywords: 60H05 ; 60H10 ; 60J65
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary We establish an Ito formula forC 1 functions of processes whose time reversal are semimartingales and forC 1 functions whose first derivatives are Hölder continuous of any parameter and the process comes out from a stochastic flow of homeomorphism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01303801
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  • 13
    Electronic Resource
    Electronic Resource
    Ito formula for C 1 -functions of semimartingales (1996)
    Springer
    Probability theory and related fields 104 (1996), S. 27-41 
    Details
    ISSN: 1432-2064
    Keywords: Mathematics Subject classification: 60H05 ; 60H10 ; 60J65
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary. We establish an Ito formula for C 1 functions of processes whose time reversal are semimartingales and for C 1 functions whose first derivatives are Hölder continuous of any parameter and the process comes out from a stochastic flow of homeomorphism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01303801
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    Paper (German National Licenses)
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  • 14
    Electronic Resource
    Electronic Resource
    An unusual type of primary cerebral hemihypotrophy with signs of dysfunctional neuronal migration (1996)
    Springer
    Acta neuropathologica 92 (1996), S. 631-634 
    Details
    ISSN: 1432-0533
    Keywords: Key words Cerebral hemihypotrophy ; Subependymal heterotopia ; Lissencephaly ; Macrogyria ; Seizures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We describe the neuropathological features of a complex brain malformation characterized by cerebral hemihypotrophy with ipsilateral lissencephaly, periventricular nodular heterotopia and macrogyria. The contralateral hemisphere showed only slight alterations of the gyral pattern and a limited periventricular gray matter heterotopia. The clinical picture of the patient, who died at the age of 15 years, consisted of severe oligophrenia, intractable seizures and left hemiparesis. We discuss the nosological status of this neuronal migration disorder of apparently unknown origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050572
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  • 15
    Electronic Resource
    Electronic Resource
    Autonomic neuropathy and transcutaneous oxymetry in diabetic lower extremities (1994)
    Springer
    Diabetologia 37 (1994), S. 1051-1055 
    Details
    ISSN: 1432-0428
    Keywords: Diabetic autonomic neuropathy ; transcutaneous oxymetry ; galvanic skin response ; blood oxygen content ; diabetic foot
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Transcutaneous oxygen tension is a useful method with which to assess the functional status of skin blood flow. The reduced values observed in diabetic patients have been interpreted as a consequence of peripheral vascular disease. However, diabetic patients show lower transcutaneous oxygen tension values than control subjects with equivalent degrees of peripheral vascular disease, suggesting that additional factors are involved. Since the autonomic nervous system influences peripheral circulation, we studied the relationship between autonomic neuropathy and foot transcutaneous oxymetry in non-insulin-dependent diabetic (NIDDM) patients without peripheral vascular disease. The following age-matched patients were selected and evaluated: control subjects, C, (n=20), NIDDM patients without autonomic neuropathy, D, (n=16) and with autonomic neuropathy, DN, (n=20). All diabetic patients showed lower transcutaneous oxygen tension values than control subjects, while no differences were observed between the diabetic patients with and without autonomic neuropathy. In addition the saturation index that increases in the presence of autonomic neuropathy does not correlate with foot TcPO2. In conclusion autonomic neuropathy does not influence foot TcPO2 and therefore it is unlikely that it contributes to development of foot lesions during induction of foot skin ischaemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400469
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  • 16
    Electronic Resource
    Electronic Resource
    Autonomic neuropathy and transcutaneous oxymetry in diabetic lower extremities (1994)
    Springer
    Diabetologia 37 (1994), S. 1051-1055 
    Details
    ISSN: 1432-0428
    Keywords: Key words Diabetic autonomic neuropathy ; transcutaneous oxymetry ; galvanic skin response ; blood oxygen content ; diabetic foot.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Transcutaneous oxygen tension is a useful method with which to assess the functional status of skin blood flow. The reduced values observed in diabetic patients have been interpreted as a consequence of peripheral vascular disease. However, diabetic patients show lower transcutaneous oxygen tension values than control subjects with equivalent degrees of peripheral vascular disease, suggesting that additional factors are involved. Since the autonomic nervous system influences peripheral circulation, we studied the relationship between autonomic neuropathy and foot transcutaneous oxymetry in non-insulin-dependent diabetic (NIDDM) patients without peripheral vascular disease. The following age-matched patients were selected and evaluated: control subjects, C, (n = 20), NIDDM patients without autonomic neuropathy, D, (n = 16) and with autonomic neuropathy, DN, (n = 20). All diabetic patients showed lower transcutaneous oxygen tension values than control subjects, while no differences were observed between the diabetic patients with and without autonomic neuropathy. In addition the saturation index that increases in the presence of autonomic neuropathy does not correlate with foot TcPO2. In conclusion autonomic neuropathy does not influence foot TcPO2 and therefore it is unlikely that it contributes to development of foot lesions during induction of foot skin ischaemia. [Diabetologia (1994) 37: 1051–1055]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400469
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  • 17
    Electronic Resource
    Electronic Resource
    Estimation de la densité de la solution de l'équation de Zakaï robuste (1995)
    Springer
    Potential analysis 4 (1995), S. 521-545 
    Details
    ISSN: 1572-929X
    Keywords: 60 H10 ; Zakaï équation ; Malliavin Calculus ; density estimates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract We study the behaviour in small time of the density of the robust Zakaï equation under the weak Hörmander's hypothesis. We avoid large deviations phenomena by supposing that the drift at the departure is equal to zero. We get an asymptotic expansion over the diagonal of the density where the observation is involved. In the case where all the terms of that asymptotic expansion are equal to zero, a pathology which is related to the Bismut's condition, we give an estimation of the decay by using a probabilistic analogous of the Gevrey methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01048067
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  • 18
    Electronic Resource
    Electronic Resource
    Creutzfeldt-Jakob disease and sheep brain a report from central and southern Italy (1979)
    Springer
    Neurological sciences 1 (1979), S. 171-174 
    Details
    ISSN: 1590-3478
    Keywords: Creutzfeldt-Jakob Disease ; Sheep Brain ; Sheep Rearing ; Fondhandling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario È stata studiata la distribuzione geografica dei luoghi di origine di 8 pazienti con CJD correlandola alla distribuzione, all'interno delle diverse regioni dell'Italia Centrale, e in parte Meridionale, delle aree a prevalente economia da pascolo, soprattutto pastorizia ovina. Si è indagata una eventuale connessione tra abitudini alimentari che comprendono la manipolazione a scopo alimentare ed il susseguente consumo di tessuti del SNC di ovini e la insorgenza della CJD. Viene avanzata la ipotesi che attraverso soluzioni di continuo nel rivestimento dei tegumenti delle estremità superiori, piuttosto che per la via della ingestione, l'agente virale della malattia potrebbe penetrare nell'organismo, per cui questo elemento sarebbe da tenere presente nell'affrontare i problemi connessi con le modalità di trasmissione della CJD.
    Notes: Abstract The places of origin of 7 out of 8 patients with CJD coincide with the distribution of sheep-rearing in central and southern Italy, confirming the suggested link between this disease and eating and-or handling sheep CNS tissue. Since 6 of the 8 cases were women, it seems more likely that the virus responsible for CJD enters the body through a break in the skin of the hands and forearms in the process of foodhandling rather than via the Digestive tract. This aspect should be borne in mind when investigating the problems of CJD transmission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02335847
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  • 19
    Electronic Resource
    Electronic Resource
    Prognostic value of cytosolic estrogen receptors in human colorectal carcinoma and surrounding mucosa (1994)
    Springer
    Digestive diseases and sciences 39 (1994), S. 2038-2042 
    Details
    ISSN: 1573-2568
    Keywords: estrogen receptors ; colorectal adenocarcinoma ; prognostic value
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Estrogen receptors have been found in normal and neoplastic gastrointestinal mucosa. The aim of our study was to verify whether the content of cytosolic estrogen receptor in normal and neoplastic tissue has a prognostic value in patients with colorectal adenocarcinoma. Eighty consecutive patients entered the study, and their follow-up was complete because non were lost to follow-up. Estrogen receptors were evaluated by an enzymatic immunoassay. Fifty-four percent of neoplastic samples and 84% of samples from surrounding mucosa showed an estrogen receptor content higher than 1.0 fmol/mg of cytosolic proteins (cut point for positive/negative hormone receptor status). Estrogen receptor levels were lower in neoplastic tissue than surrounding mucosa (1.2±1.05 fmol/mg protein vs 2.07±1.36 fmol/mg protein, respectively,t testP=0.001). The survival of patients with estrogen receptor expression in uninvolved surrounding mucosa was longer than that of patients without estrogen receptor in the same type of mucosa (log rank test,P〈0.01). In the neoplastic tissue, receptor status had no prognostic value (log rank,P=0.8). After taking into account the most important potential confounders by using the Cox proportional hazard model, the estrogen receptor status in normal mucosa samples maintained an independent prognostic value. These results support an association between the estrogen receptor status in normal mucosa and survival of patients with colorectal adenocarcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02088144
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  • 20
    Electronic Resource
    Electronic Resource
    Autoradiographic assessment of pineal gland glucose utilization and capillary permeability in the unanesthetized rat (1990)
    Springer
    Child's nervous system 6 (1990), S. 222-224 
    Details
    ISSN: 1433-0350
    Keywords: Pineal gland ; Glucose metabolism ; Capillary permeability ; Quantitative autoradiography ; Positron emission tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pineal gland glucose utilization (GU) and capillary permeability (CP) were measured in unanesthetized rats, using complementary quantitative autoradiographic techniques. GU values within the pineal tissue were homogeneously distributed around 70 μmol of glucose/100 g each min, i.e., they were approximately 30% lower than in the cortical gray structures. The blood-to-brain transfer constant of [14C]-α-aminoisobutyric acid, as an index of CP, was up to ten orders of magnitude higher than that for the rest of the brain. These measurements were carried out at that point in the circadian rhythm that corresponds to the minimum level of neurosecretory activity of the pineal gland.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01850978
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