Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 11
    ISSN: 1420-908X
    Keywords: Lipopolysaccharide ; Interleukin 13 ; Pyrexia ; Flezelastine ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of the novel antiasthmatic/antiallergic compound flezelastine on LPS-induced actions were investigatedin vitro andin vivo. In monocytes, IL-1β generation stimulated by LPS was inhibited dose dependently.In vivo, LPS-induced fever in rats, which is at least partly driven by the release of IL-1β, was also inhibited by flezelastine. These findings suggest that flezelastine inhibits IL-1 synthesis and/or releasein vitro andin vivo.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 12
    Electronic Resource
    Electronic Resource
    Springer
    Inflammation research 31 (1990), S. 229-236 
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of azelastine, an orally effective antiasthmatic/antiallergic drug, on the generation of oxygenderived free radicals in phagocytes was investigated using different chemiluminescence-assays. The chemiluminescence (CL) of both human polymorphonuclear granulocytes (PMNL) and guinea-pig alveolar macrophages (AM) was induced either by phorbol myristate acetate (PMA) or zymosan and amplified either by lucigenin or DMNH (7-dimethylamino-naphthalene-1,2-dicarbonic-acidhydrazide). The inhibitory effect of azelastine was dependent on the inducer employed and the condition and type of cells used. Azelastine reduced PMA-induced CL concentration-dependently in both PMNL (IC30=3.9 μM) and AM (IC30=9.8 μM). In AM zymosan-induced CL was inhibited 21.7% by 10 μM azelastine, whereas in PMNL it remained unchanged up to 10 μM azelastine. Azelastine has a significantly stronger inhibitory effect (IC30=4.2 μM) on oxygen free radical generation in AM primed by fetal calf serum than in unprimed AM. Based on present results it is likely that azelastine inhibitis oxygen-derived free radical generation by interaction with protein kinase C.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 13
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion The high potency of the small intestine to inactivate vasoactive biogenic amines is a combined effect of diamine and monoamine oxidase activity. Histamine, however, is specifically deaminated by diamine oxidase.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 14
    ISSN: 1432-0541
    Keywords: Key words. Computational biology, Protein structure, Coiled-coil, Epitope, Dynamic programming.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract. We describe a simple approach for finding identical amino acid clusters on the outer surface of α -helical coiled-coil proteins by examining the sequence of amino acids that compose the protein. Finding such similarities is an important immunological problem, since these may correspond to cross-reactive epitopes, i.e., sites at which antibodies produced against one protein also bind to another conformationally similar protein. Because of the regularities inherent in a coiled-coil structure the position of each amino acid on the structure is predicted. Based on this prediction, our algorithm finds similarities on the outer surface of the proteins. The matches found by our algorithm serve as an important screening process, intended to indicate which experiments to conduct to determine sites that correspond to cross-reactive epitopes. The location of several cross-reactive epitopes between M proteins and myosins had been verified experimentally. Although our approach makes many simplifying assumptions, these epitopes always correspond to clusters of identical amino acids, which our algorithm predicted to be contiguous on the outer surface. Our algorithm runs in O(n+m+r) time and O(n+m) space, where n and m are the lengths of the protein sequences, and r is the number of matching amino acids that appear in the same structural position of the α -helix in both sequences.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 15
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Postoperative Phase ; Ösophagustemperatur ; Blasentemperatur ; Rektaltemperatur ; Vergleich verschiedener Meßorte ; Key words Postoperative period ; Oesophageal temperature ; Bladder temperature ; Rectal temperature ; Comparison of different sites of measurement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Objective: The data of 60 postoperatively sedated and ventilated patients were studied for analysis of oesophageal, bladder, and rectal temperatures. The purpose of the investigation was to clarify whether changes of oesophageal temperature are adequately reflected by bladder and rectal temperatures and whether the rate of rewarming has an influence on the accuracy of the latter two sites. Methods: For temperature recording, a Hi-Lo Temp® esophageal stethoscope (Mallinckrodt Medical), a Foley FC400-18 catheter temperature sensor (Respiratory Support Products, Mallinckrodt Medical), and a rectal temperature probe N401 (YSI) were used. Each probe and matching recording unit was calibrated over a range of 30–40 °C against a reference quartz thermometer (Hewlett packard Model 2801 A) in a thermostated water bath before the investigation. Five measuring points distributed over the whole period of rewarming were evaluated. Patients were assigned to groups with slow and fast rewarming, respectively. Agreement between the methods of measurement was assessed as described by Bland and Altman. Furthermore, differences between the oesophageal and bladder or rectal temperature were checked at each measuring point for statistical significance using the t-test. Results: In regard to oesophageal temperature, the bladder and rectal temperatures had biases of –0.01 °C and –0.03 °C, respectively. Limits of agreement (±2 s) were ±0.68 °C and ±0.82 °C, respectively. The bias of the bladder temperature was independent of the rate of rewarming (Fig. 3). The bias of the rectal temperature, however, differed in regard to the rewarming rate, being +0.06 °C in the group with slow rewarming and –0.13 °C in the group with fast rewarming (Tables 1 and 2, Fig. 1 and 2). These differences were significant for the measuring points 4 and 5 (Fig. 4). Conclusions: Bladder and rectal temperatures can accurately indicate the oesophageal temperature with a very small bias in postoperatively sedated and ventilated patients. Since the rate of rewarming influences the accuracy of rectal temperature readings, monitoring of bladder temperature seems to be more favourable in the postoperative period.
    Notes: Zusammenfassung In einer retrospektiven Untersuchung wurden bei 60 postoperativ nachbeatmeten Patienten während der Phase der Wiedererwärmung die Temperaturen in Ösophagus, Blase und Rektum miteinander verglichen. Ziel der Untersuchung war zu klären, wie gut Blasen- und Rektaltemperatur mit der Ösophagustemperatur übereinstimmten und ob die Wiedererwärmungsgeschwindigkeit einen Einfluß auf die Genauigkeit dieser beiden Meßorte hatte. Material und Methoden: Es wurden fünf Meßpunkte pro Patient berücksichtigt, die zu gleichen Teilen über die Wiedererwärmungsperiode verteilt wurden. Um den Einfluß der Wiedererwärmungsgeschwindigkeit zu erfassen, wurden die Patienten retrospektiv einer Gruppe mit schneller oder langsamer Wiedererwärmung zugeordnet. Ergebnisse: Die Blasentemperatur weist gegenüber der Ösophagustemperatur eine systematische Abweichung von –0,01 °C und eine Meßunsicherheit (±2 s) von ±0,68 °C auf und ist unabhängig von der Wiedererwärmungsgeschwindigkeit. Die Rektaltemperatur zeigt eine systematische Abweichung von –0,03 °C und eine Meßunsicherheit von ±0,82 °C. Die systematische Abweichung der Rektaltemperatur betrug bei langsamer Wiedererwärmung ±0,06 °C, bei schneller Wiedererwärmung hingegen –0,13 °C. Die Unterschiede waren für die Meßpunkte 4 und 5 statistisch signifikant. Schlußfolgerung: Aus diesem Grund scheint die Messung der Blasentemperatur in der postoperativen Phase vorteilhafter zu sein als die Messung der Rektaltemperatur.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 16
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Infusionswärmung ; Durchflußwärmer ; Hypothermie ; Wärmeverluste ; Key words Body temperature ; Hypothermia ; Infusion ; Blood transfusion ; Equipment design
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Heat loses during surgery occur mainly to the environment and due to infusions and irrigations. Infusions given at room temperature account for a great deal of the total heat deficit during major operations, e.g., the infusion of 53 ml/kg 20° C fluid leads to a loss of 1° C in mean body temperature. Hence, heating i.v. fluids will add to the effect of other measures aimed at reducing heat loss to the environment. We investigated the efficacy of different warming methods for i.v. fluids in an experimental model by measuring the temperature at the end of the delivery line. Methods. The following in-line warmers were studied: Hotline HL-90 and System H-250/heat exchanger D-50 (Level 1 Technologies, Marshfield, USA), Astotherm IFT 260 (Stihler Elektronic GmbH, Stuttgart, Germany), RSLB 30 H Gamida (Productions Hospitalieres Francaises, Eaubonne, France), Bair Hugger 241/Modell 500 Prototype (Augustine Medical, Eden Prairie, USA). They were compared with prewarming infusions (39° C) only using the Clinitherm S (Labor Technik Barkey GmbH, Bielefeld, Germany) and prewarming with “active insulation” of the delivery line using the Autotherm/Autoline system (Labor Technik Barkey GmbH, Bielefeld, Germany). We investigated the influence of four variables on the efficacy of warming: (1) flow rate (50–15,000 ml/h); (2) ambient temperature (20° C and 25° C); (3) infusion bag temperature (6° C, 20° C, and 39° C); and (4) length of infusion system downstream from the heat exchanger. Fluid temperatures were measured using thermistors of 1 mm diameter (Modell YSI 520, Yellow Springs Instruments Co., Yellow Springs, USA) incorporated into 3-way stopcocks. Temperatures were recorded using Hellige temperature monitors (Hellige GmbH, Freiburg im Breisgau, Germany) and the signals were collected at 10 Hz through an AD converter and averaged over 1 min. Flows were calculated by timed collection into calibrated cylinders; 10 to 12 different flow rates were taken to define one temperature/flow plot. Effective warming was defined as a temperature 〉33° C at the end of the infusion line. Results. At high flow rates (〉2,500 ml/h) using 20° C fluids at 20° C ambient temperature, the H-250/D-50 system gave the highest temperatures throughout the range and showed effective warming from 1,300 ml/h on over the entire range tested (35° C at 17,000 ml/h) compared to the RSLB 30 H Gamida system (3,000–18,000 ml/h) (Fig. 2). This difference in performance was almost abolished with fluids at 6° C (Fig. 4). Similar efficacy could be reached by using prewarmed infusions that gave effective warming at 〉2,000 ml/h and reached 39° C at 13,000 ml/h. Prewarmed infusions could be used effectively down to 〉80 ml/h applying “active insulation” (Autotherm/Autoline) to the whole infusion system. The Hotline HL-90 (50–4,700 ml/h) appeared to be the most effective in-line warmer in the low (〈250 ml/h) and middle (250–2,500 ml/h) flow range, followed by the Astotherm IFT 260 (400–4,000 ml/h), but only if used with a length of 40 cm down-stream from the heat exchanger (Fig. 1). Increasing this distance to 145 cm markedly reduced its efficacy below the range of 2,000 ml/min (1,200–3,000 ml/h) (Fig. 5). The Bair Hugger 241 Prototype showed a narrow effective range (700–1,300 ml/h) that could be extended beyond 1,300 ml/h by the use of prewarmed infusions (Figs. 1 and 3). The performance for 6° C solutions and ambient temperatures of 25° C are given in Fig. 4 and Table 1. Conclusions. The importance of infusion warming increases with the amount of fluid given. In general, the infusion bag temperature only influenced the efficacy of in-line warmers within the high-flow range, challenging the performance of the heat exchanger. The length of uninsulated i.v. line downstream from the heat exchanger influenced the efficacy within the low- and middle-flow range, as did the room temperature. Prewarmed solutions can be infused very effectively within the high-flow range. This efficiency can be preserved down to the low-flow range by using “active insulation” of the infusion system. In-line warming is essential for emergency and rapid massive transfusions.
    Notes: Zusammenfassung Eine Hypothermie gehört zu den häufigsten Komplikationen in der perioperativen Phase. Eine ihrer Ursachen liegt in der Applikation unzureichend erwärmter Blut- und Infusionslösungen. Es wurde die Effektivität verschiedener Erwärmungsverfahren untersucht: 1) Vorwärmung von Infusionen (39° C) und 2) Verschiedene Durchflußwärmer (System H-250 ® /D-50 ® , RSLB 30 H Gamida ® , Hotline ® HL-90, Autotherm ® /Autoline ® , Astotherm ® IFT 260, Bair Hugger ® 241 Prototyp). Als Effektivitätsgrenze wurde eine patientennahe Infusionstemperatur von ≥33° C definiert. Variiert wurden a) Flußrate (50–15000 ml/h), b) Ausgangstemperatur der Infusion (6, 20 und 39° C), c) Länge des Infusionssystems nach dem Wärmetauscher und d) Umgebungstemperatur (20 und 25° C). Für eine Raum- und Infusionstemperatur von 20° C wurden folgende effektive Arbeitsbereiche gefunden: System H-250 ® /D-50 ® 1300- bis mindestens 17000 ml/min, RSLB 30 H Gamida ® 3000–18000 ml/min, Hotline ® HL-90 50–4700 ml/min, Astotherm ® IFT 260 Infusionssystemlänge 40 cm: 400–4000 ml/min, Infusionssystemlänge 145 cm: 1200–3000 ml/min, Bair Hugger ® 241 700–1300 ml/min, Autotherm ® /Autoline ® mit vorgewärmten Infusionen (39° C) 〉80 ml/min, vorgewärmte Infusionen (39° C) ohne „aktive Isolation“ 〉2000 ml/min. Für die getesteten Variablen gilt: Eine geringe Ausgangstemperatur der Infusion reduziert nur im hohen Flußbereich die Effektivität der Wärmer. Je niedriger Flußrate und Umgebungstemperatur sind und je länger das Infusionssystem nach dem Wärmetauscher ist, desto größer wird der Temperaturverlust auf dem Weg zum Patienten. Bis zu einem Infusionsfluß von 2000 ml/h ist eine effektive Infusionswärmung alleine durch Vorwärmung (39° C) generell nicht möglich.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 17
    Electronic Resource
    Electronic Resource
    Springer
    Abdominal imaging 20 (1995), S. 176-178 
    ISSN: 1432-0509
    Keywords: Magnetic resonance imaging ; Neurofibroma ; Prostate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pelvic neurofibromatosis is a rare disease and rarely involves the prostate. A 19-year-old male presented with irritative and obstructive voiding symptoms. Magnetic resonance imaging showed a large mass extending from the sacral promontory to the perirectal and perivesical spaces and to the proximal root of the penis. The mass also involved the prostate. The characteristics of the mass were highly suggestive for neurofibroma. Prostate biopsy showed neurofibroma, and the immunohistochemistry stain for S-100 protein was positive.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 18
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 49 (1971), S. 561-562 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 16 Patienten mit terminaler Niereninsuffizienz wurde vor und nach 22 Peritonealdialysen die Konzentration an proteingebundenem Jod127 im Serum gemessen. Es fand sich ein in mehreren Gruppen reproduzierbarer signifikanter Anstieg, der nicht mit Änderungen von Hämatokrit, Serum Gesamteiweiß, Gewichtsbilanz, Blut- und Plasmavolumen korreliert war. Als mögliche Ursache des PB127I-Anstieges wird eine TSH-induzierte Mehrsekretion von Schilddrüsenhormon nach initialem Absinken von freiem und Gesamt-Thyroxin während der Peritonealdialyse diskutiert.
    Notes: Summary A significant increase of serum protein-bound (PB)127I was observed after 22 peritoneal dialyses in 16 patients with terminal renal failure. No correlation with changes in body weight, haematocrit, total serum protein nor blood or plasma volume was found.—The increase of PB127I during peritoneal dialysis may be ascribable to an initial fall of free and total thyroxine followed by a rise in TSH secretion.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 19
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 61 (1983), S. 1217-1231 
    ISSN: 1432-1440
    Keywords: RNA tumor viruses ; Human leukemia ; Viral carcinogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The detection and characterization of oncogenes via RNA tumor viruses (or retroviruses) and the recognition of their location at breakpoints of chromosomal translocations which are frequently found in certain human neoplasms has promoted present understanding of molecular mechanisms underlying carcinogenesis. Oncogenes are cellular genes which can be transduced by RNA tumorviruses and induce malignant transformation under experimental conditions in vivo and in vitro. A role of retroviruses in human leukemogenesis is suggested by epidemiological observations and by the isolation of such viruses from several human T-cell leukemias and lymphomas (human T-cell leukemia/lymphoma virus or HTLV) as well as by biochemical association of retroviral markers with human leukemias. A role of HTLV has been suggested also in a human immune deficiency syndrome (AIDS). In view of the well known role of many factors in carcinogenesis the concept of carcinogenesis as a multistep process as well as the concept of cocarcinogenesis and the role of cofactors other than viruses, such as radiation and chemicals, aging, hormones, graft vs host reaction, environmental factors etc., will have to be carefully considered.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 20
    Electronic Resource
    Electronic Resource
    Springer
    Microbial ecology 31 (1996), S. 281-290 
    ISSN: 1432-184X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Holdfast exopolymers of the dimorphic oligotrophic bacterium Seliberia stellata were examined using fluorescent lectins under light microscopy and colloidal gold lectins using transmission electron microscopy. Examination using fluorescent-labeled lectins revealed that lectins specific for polysaccharides and monosaccharides such as glucose and/or mannose, galactose, N-acetylgalactosamine, and N-acetylglucosamine (and its dimer) adhered to holdfast structure. Colloidal gold-labeled lectin assays also suggested the presence of these sugars. Both the holdfast that mediates swarmer cell adhesion and the holdfast that facilitates rosette formation gave similar results, suggesting the structures may be the same. Another exopolymer produced later in the growth cycle was observed using transmission electron microscopy. It appeared as an amorphous glycocalyx-like material very different from holdfast exopolymers. Retention of the gold lectin Wheat Germ Agglutinin (WGA), suggested the presence of N-acetylglucosamine, but fluorescent analyses were unsuccessful. The data suggest that S. stellata produces at least two different exopolymers: (a) the exopolymer of the swarmer cell and rosette holdfast whose function is adhesion and whose composition is (but may not be limited to) polysaccharides and (b) a slime-like exopolymer whose composition and function remain unknown.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...