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  • 11
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1962)
    Springer
    Journal of molecular medicine 40 (1962), S. 921-928 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01482944
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  • 12
    Electronic Resource
    Electronic Resource
    Cortisol- und Corticosteronsekretion bei der Akromegalie (1968)
    Springer
    Journal of molecular medicine 46 (1968), S. 1008-1010 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The mean cortisol secretion rate was significantly elevated in fifteen patients with acromegaly. The increase was especially pronounced in untreated patients while in treated ones the mean value was close to that of normal persons. Calculated as secretion rate per kg body weight there was also a significant elevation in patients with untreated acromegaly. Conversely, in treated patients the value was in the low normal range. In four patients with active acromegaly the cortisol secretion rate per kg body weight was significantly higher than in those with an inactive, untreated pituitary process. The corticosterone secretion rate in nine investigated patients with acromegaly was also significantly increased, both in absolute terms and expressed per kg body weight.
    Notes: Zusammenfassung Die mittlere Cortisolsekretion war bei 15 Akromegaliepatienten signifikant erhöht. Die Steigerung war besonders ausgeprägt bei den unbehandelten Patienten, während sich der Mittelwert bei den behandelten dem der Normalpersonen annäherte. Bezogen auf das Körpergewicht fand sich bei den unbehandelten Akromegalen ebenfalls eine signifikant erhöhte Cortisolsekretion. Bei den behandelten lag sie dagegen im untersten Normbereich. Bei vier Patienten mit einer floriden Akromegalie ließ sich gegenüber denjenigen mit einem unbehandelten, inaktiven HVL-Prozeß eine signifikant erhöhte Cortisolsekretion pro kg Körpergewicht nachweisen. Die Corticosteronsekretion war bei neun untersuchten Patienten absolut und bezogen auf das Körpergewicht signifikant gesteigert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745596
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  • 13
    Electronic Resource
    Electronic Resource
    Das Verhalten intraoperativ entstandener tiefer Venenthrombosen, beurteilt anhand wiederholter Phlebographien (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 521-526 
    Details
    ISSN: 1432-1440
    Keywords: Deep vein thrombosis ; phlebography ; postoperative ; fibrinogen test ; postthrombotic syndrom ; Tiefe Venenthrombose ; Phlebographie ; postoperativ ; Fibrinogentest ; postthrombotisches Syndrom
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Im Rahmen einer prospektiven, randomisierten und kontrollierten Studie, in der die Thromboseprophylaxe-Mittel Dextran und Heparin bei allgemein-chirurgischen und urologischen Patienten geprüft werden, phlebographierten wir 31 Patienten mit sicherer tiefer Venenthrombose sofort nach der Diagnosestellung mittels125J-Fibrinogentest. 16 Patienten wurden 14 Tage später ein zweites Mal phlebographiert.Alle Thromben entstanden intraoperativ. 24 von 31 Patienten zeigten einemultifokale Entstehung der Thromben. Unabhängig vom Prophylaxe-Mittel und der eingeleiteten Therapie machten die Thromben in den ersten 14 Tagen nach deren Entstehung folgende Veränderungen durch: 9 retrahierten sich, 6 verschwanden, ohne Wandveränderungen aufzuweisen, und 1 verschloß das befallene Gefäß noch vollständig. 2 Thromben verschwanden ohne jegliche Therapie; 4 weitere unter Heparin- und/oder Phenprocoumonbehandlung.
    Notes: Summary Phlebography was carried out in a prospective randomised, controlled study during which dextran and small doses of s.c. heparin have been compared in general surgical and urological patients, in 31 persons with proven deep vein thrombosis diagnosed with the125I-fibrinogen test. In 16 out of the 31 patients a second phlebogram could be performed two weeks later. In this study all thrombi occurred intraoperatively. In 24 of the 31 patients, the appearance of thrombi was multilocular. Independent of the prevention instituted and irrespective of the therapy, the following phenomena could be seen 14 days after the first phlebogram: 9 thrombi retracted, 6 disappeared completely and 1 occluded the vein completely. 2 thrombi disappeared without any therapy whatsoever, the 4 others disappeared in patients receiving heparin and/or coumarin for treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468973
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  • 14
    Electronic Resource
    Electronic Resource
    Erfahrungen mit einem neuen Teststreifen zur Blutzuckerbestimmung (1968)
    Springer
    Journal of molecular medicine 46 (1968), S. 618-619 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Experiences with a New Test-strip for Bloodsugar Determination. Blood-sugar values were estimated in 643 in- and out-patients with the new test-strip “Haemo-Glucotest”. Blood-sugar determinations performed with the Auto-Analyzer (Hoffmann) served as an objective control. The treatment of out-patients was determined according to the values of the “Haemo-Glucotest” strip and before the Auto-Analyzer results arrived. 80% of the estimated values varied from the Auto-Analyzer results by less than ± 20 mg-%. Preliminary therapy had to be modified in only 6% of the patients. The precision of the determination depends upon illumination and the ability for color discrimination of the person working with the test-strip. The “Haemo-Glucotest” strip is not only suitable for detection of hyperglycemia and hypoglycemia, but also for control of therapy in diabetic out-patients.
    Notes: Zusammenfassung Der Teststreifen Hämo-Glucotest wurde an 643 stationär und ambulant behandelten Diabetikern erprobt. Als objektiver Vergleich dienten die Blutzuckerbestimmungen nachHoffmann im Autoanalyzer. Die Behandlung der ambulanten Patienten wurde nach den Ergebnissen des Hämo-Glucotest vor Kenntnis der Autoanalyzerbestimmung festgelegt. 80% der geschätzten Werte wichen um weniger als ± 20 mg-% von den durch Autoanalyzer bestimmten Blutzuckerwerten ab. Die nach den Testergebnissen vorläufig festgelegte Therapie der ambulanten Patienten brauchte nur in 6% der Fälle korrigiert zu werden. Die Genauigkeit der Bestimmung ist von den Beleuchtungsverhältnissen während des Tests und vom Farbunterscheidungsvermögen des Untersuchers abhängig. Der Teststreifen eignet sich nicht nur zur Erfassung von Hypo- und Hyperglykämien, sondern auch für eine orientierende Blutzuckerbestimmung bei der ambulanten Einstellungskontrolle von Diabetikern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01747844
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  • 15
    Electronic Resource
    Electronic Resource
    Typische Veränderungen Des Atp + Adp-Gehaltes Menschlichen Blutes Nach Kongorotinjektionen Bei Gesunden Und Leberkranken (1957)
    Springer
    Journal of molecular medicine 35 (1957), S. 1027-1029 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung 1. Nach intravenöser Injektion von kolloidalen Substanzen oder Kongorot steigen die Werte von ATP + ADP im Blut von Kaninchen und Menschen an. 2. Der zeitliche Ablauf dieses Anstiegs wird am besten durch Bestimmungen unmittelbar vor und 2, 4, 7 und 24 Std nach der Injektion erfaßt. Kurvenmäßig dargestellt ergeben die gewonnenen Werte relativ gleichförmige ansteigende und nach 4–7 Std wieder abfallende Kurven. 3. Derartige Kurven wurden an 40 Gesunden, 40 Leberkranken und der gleichen Zahl Patienten mit den verschiedensten anderen Krankheitengewonnen. 4. Mit hoher Regelmäßigkeit traten bei Leberkranken abfallende Werte auf, die bei andern Krankheiten nicht beobachtet werden. 5. Es wirken sich offenbar schon recht kleine Störungen der Leberfunktion in dem geschilderten Sinne aus, so daß durch Äthernarkose entstandene interkurrente Leberschäden noch 12–14 Tage lang nachgewiesen werden können.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01488729
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  • 16
    Electronic Resource
    Electronic Resource
    Modulation of neuronal calcium channels by arachidonic acid and related substances (1995)
    Springer
    The journal of membrane biology 145 (1995), S. 233-244 
    Details
    ISSN: 1432-1424
    Keywords: Ca2+ current ; Arachidonic acid ; Myristic acid ; Tetradecyltrimethylammonium ; Sphingosine ; Neuroblastoma x glioma hybrid cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Low-voltage-activated (1-v-a) and high-voltage-activated (h-v-a) Ca2+ currents I Ca were recorded in whole-cell voltage clamped NG108-15 neuroblastoma x glioma hybrid cells. We studied the effects of arachidonic acid (AA), oleic acid, myristic acid and of the positively charged compounds tetradecyltrimethyl-ammonium (C14TMA) and sphingosine. At pulse potentials 〉−20 mV, AA (25-100 μm) decreased 1-v-a and h-v-a I Ca equally. The decrease developed slowly and became continually stronger with increasing time of application. It was accompanied by a small negative shift and a slight flattening of the activation and inactivation curves of the 1-v-a I Ca. The shift of the activation curve manifested itself in a small increase of 1-v-a I Ca at pulse potentials 〈−30 mV. The effects were only partly reversible. The AA effect was not prevented by 50 μm 5, 8, 11, 14-eicosatetraynoic acid, an inhibitor of the AA metabolism, and not mimicked by 0.1–1 μm phorbol 12, 13-dibutyrate, an activator of protein kinase C. Probably, AA directly affects the channel protein or its lipid environment. Oleic and myristic acid acted similarly to AA but were much less effective. The positively charged compounds C14TMA and sphingosine had a different effect: They shifted the activation curve of 1-v-a I Ca in the positive direction and suppressed 1-v-a more than h-v-a I Ca; their effect reached a steady-state within 5–10 min and was readily reversible. C14TMA blocked 1-v-a I Ca with an IC50 of 4.2 μm while sphingosine was less potent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00232715
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  • 17
    Electronic Resource
    Electronic Resource
    Mikroskopische und elektronenmikroskopische Untersuchungen am Gitterfasersystem der Corpusmucosa während des Cyclus und der Gestation (1958)
    Springer
    Archives of gynecology and obstetrics 191 (1958), S. 212-223 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es wurden licht- und elektronenmikroskopische Untersuchungen am Gitterfasersystem des Corpusendometriums vorgenommen. Dabei konnte festgestellt werden, daß das endometrane Fasergerüst, welches wahrscheinlich extracellulärer Herkunft ist, während des Cyclus und in der Gravidität charakteristischen Veränderungen unterworfen ist. Mehrere Tatsachen sprechen dafür, daß das Gitterfasersystem mit den zelligen Bestandteilen der Corpusmucosa eine anatomische und funktionelle Einheit bildet. Bei den Forschungen über das Corpusendometrium müssen daher beide Systeme gleichzeitig berücksichtigt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00678863
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  • 18
    Electronic Resource
    Electronic Resource
    Heat and mass transport in the photoacoustic effect on liquids (1991)
    Springer
    Applied physics 52 (1991), S. 223-233 
    Details
    ISSN: 1432-0630
    Keywords: 44.25 ; 44.60+f ; 47.25.Q
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract The temperature oscillation accompanying the photoacoustic effect generates a periodic variation of the vapor pressure of a liquid. The propagation of the oscillating concentration of the vapor in the inert cell gas (air) is described by a mass diffusion wave on which a convective motion of the gas is superposed. The diffusion wave characterized by the diffusion coefficient of the cell gas alone can be measured by the Mirage effect, whereas a microphone detects the total mass flux including the convective flux, which increases with temperature. On approaching the boiling temperature, the convective flow will govern the oscillating transport of mass. The photoacoustic signal is determined directly from the flux of heat and mass at the boundary between liquid and gas using the Gauss' divergence theorem. We have found that the temperature behaviour of the amplitude and phase angle of the photoacoustic signal depends on the length of the gas column in the cell. The contribution of thermal expansion to the photoacoustic signal is considered using the composite piston model. The results of the calculations agree fairly well with the experimental data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00324582
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  • 19
    Electronic Resource
    Electronic Resource
    The cephalosporin antibiotics in pediatric therapy (1986)
    Springer
    European journal of pediatrics 144 (1986), S. 532-538 
    Details
    ISSN: 1432-1076
    Keywords: Cephalosporins ; Specific uses ; Pharmacokinetics ; Microbiologic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The cephalosporins have been available for clinical use for nearly 20 years and a large number is presently marketed, including drugs with a wide range of different pharmaokinetic and microbiologic properties. While some of these agents have certain specific uses in which they excel, the cephalosporins have not replaced older antibiotics but do provide the physician with a broader range of choices for the treatment of many infections, allowing greater individualization of therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496029
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  • 20
    Electronic Resource
    Electronic Resource
    Immunogenicity and reactogenicity of a Haemophilus influenzae type b tetanus conjugate vaccine when administered separately or mixed with concomitant diphtheria-tetanus-toxoid and acellular pertussis vaccine for primary and for booster immunizations (1998)
    Springer
    European journal of pediatrics 157 (1998), S. 208-214 
    Details
    ISSN: 1432-1076
    Keywords: Key wordsHaemophilus influenzae type b ; Acellular pertussis ; Vaccination ; PRP-tetanus ; Diphtheria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract With an increasing number of new vaccines available for routine childhood immunization, combination vaccines are needed in order to maintain or achieve a high compliance with recommended immunization programmes. In a prospective, randomized, comparative, multi-centre study, 822 healthy infants were enrolled to receive three doses of either a candidate or a commercially available Haemophilus influenzae type b (Hib) vaccine concomitantly with diphtheria-, tetanus- acellular pertussis (DTaP) vaccine. Study subjects were randomly allocated to one of the following groups: (1) separate, or (2) mixed injection of DTaP and candidate Hib vaccine, or (3) separate injection of DTaP and commercial Hib vaccine. One year later the first 189 study subjects received either separate or mixed injections of the same Hib and DTaP vaccines as booster doses. Evaluation of reactogenicity was based on diary cards completed by parents. Immunogenicity was documented by measuring IgG antibody concentrations in serum samples taken before and 4 weeks after primary and booster vaccination. No serious adverse events occurred and most local and systemic reactions were mild to moderate. Booster doses were more reactogenic than primary doses with all groups. Antibody concentrations against pertussis antigens were similar to those seen with DTaP alone. All but one subject had protective antibody concentrations against diphtheria and tetanus. Primary immune response to the Hib vaccine was significantly lower in the group receiving the mixed Hib-DTaP vaccine, however, ≥95% of vaccinees had anti-Hib antibody concentrations ≥0.15 μg/ml and there was a marked booster response (〉100-fold) in all groups. Conclusions Mixing DTaP and Hib vaccines for primary immunization caused a decrease in anti-Hib antibody response, although after primary immunization as after booster doses, all subjects showed antibody concentrations considered to be protective for invasive Hib disease. Mixing of the vaccines did not result in increased reactogenicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050797
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