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  • 11
    Electronic Resource
    Electronic Resource
    Nation-wide randomized comparative study of doxorubicin, vincristine and prednisolone combination therapy with and without L-asparaginase for adult acute lymphoblastic leukemia (1994)
    Springer
    Cancer chemotherapy and pharmacology 33 (1994), S. 359-365 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A randomized clinical trial of combination chemotherapy for adult acute lymphoblastic leukemia (ALL) with doxorubicin, vincristine and prednisolone with and withoutL-asparaginase (AdVP vs L-AdVP) was conducted, involving 58 institutions throughout Japan. After reaching complete remission (CR), patients were treated with the same regimen for more than 2 years. Among 166 evaluable cases of the 198 cases enrolled, CR rates were 63.1% (53/84) with AdVP and 64.6% (53/82) with L-AdVP (P=0.837). Median survival times and 7-year survival rates were 12.7 months and 21.2% with AdVP, and 16.0 months and 22.3% with L-AdVP (P=0.955 by generalized Wilcoxon test [GW],P=0.952 by log-rank test [LR]). Median diseasefree survival times and 7-year survival rates were 13.5 months and 23.8% with AdVP and 17.0 months and 30.6% with L-AdVP, showing some increments for L-AdVP but no statistical significance (P=0.141 by GW,P=0.300 by LR). Among the cases of extramurally confirmed FAB subtypes, CR rates were 75.9% (63/83) for the L1 subtype and 51.3% (39/76) for the L2 subtype (P=0.001). As to adverse effects, pancreatitis was complicated more frequently in L-AdVP than in AdVP (P=0.039). Other side effects such as hyperbilirubinemia, diabetes mellitus, diarrhea and hypofibrinogenemia were observed more frequently with L-AdVP, but with no statistical significance. Thus, addition of a single course of L-asparaginase in the induction phase of combination chemotherapy with doxorubicin, vincristine and prednisolone did not significantly enhance the effect of antileukemic treatment of adult ALL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686263
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  • 12
    Electronic Resource
    Electronic Resource
    Nation-wide randomized comparative study of doxorubicin, vincristine and prednisolone combination therapy with and without L-asparaginase for adult acute lymphoblastic leukemia (1994)
    Springer
    Cancer chemotherapy and pharmacology 33 (1994), S. 359-365 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. A randomized clinical trial of combination chemotherapy for adult acute lymphoblastic leukemia (ALL) with doxorubicin, vincristine and prednisolone with and without L-asparaginase (AdVP vs L-AdVP) was conducted, involving 58 institutions throughout Japan. After reaching complete remission (CR), patients were treated with the same regimen for more than 2 years. Among 166 evaluable cases of the 198 cases enrolled, CR rates were 63.1% (53/84) with AdVP and 64.6% (53/82) with L-AdVP (P = 0.837). Median survival times and 7-year survival rates were 12.7 months and 21.2% with AdVP, and 16.0 months and 22.3% with L-AdVP (P = 0.955 by generalized Wilcoxon test [GW], P = 0.952 by log-rank test [LR]). Median disease-free survival times and 7-year survival rates were 13.5 months and 23.8% with AdVP and 17.0 months and 30.6% with L-AdVP, showing some increments for L-AdVP but no statistical significance (P = 0.141 by GW, P = 0.300 by LR). Among the cases of extramurally confirmed FAB subtypes, CR rates were 75.9% (63/83) for the L1 subtype and 51.3% (39/76) for the L2 subtype (P = 0.001). As to adverse effects, pancreatitis was complicated more frequently in L-AdVP than in AdVP (P = 0.039). Other side effects such as hyperbilirubinemia, diabetes mellitus, diarrhea and hypofibrinogenemia were observed more frequently with L-AdVP, but with no statistical significance. Thus, addition of a single course of L-asparaginase in the induction phase of combination chemotherapy with doxorubicin, vincristine and prednisolone did not significantly enhance the effect of antileukemic treatment of adult ALL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686263
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  • 13
    Electronic Resource
    Electronic Resource
    Exposure-response relationships between woodworking, smoking or passive smoking, and squamous cell neoplasms of the maxillary sinus (1990)
    Springer
    Cancer causes & control 1 (1990), S. 165-168 
    Details
    ISSN: 1573-7225
    Keywords: Case-control study ; logistic models ; maxillary sinus neoplasms ; occupations ; sinusitis ; tobacco smoke pollution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: A case-control study of squamous cell neoplasms of the maxillary sinus was performed in Hokkaido during 1982–86, with 169 cases and 338 controls matched for sex, age, and residence. The data were analyzed by a stepwise forward-telection method based on a conditional logistic-regression model without interaction terms, log-likelihood ratio tests, and chi-square tests for trend. Statistically significant linear trends were observed for associations between the risk of squamous-cell maxillary-sinus neoplasms and the duration of woodworking among men, the daily or lifetime amount of smoking among men, and the number of smokers in the household as an index of domestic exposure to cigarette smoke among women.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00053168
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  • 14
    Electronic Resource
    Electronic Resource
    Successful treatment of chronic idiopathic neutropenia using recombinant granulocyte colony-stimulating factor (1991)
    Springer
    Annals of hematology 62 (1991), S. 22-24 
    Details
    ISSN: 1432-0584
    Keywords: Chronic idiopathic neutropenia ; Granulocyte colony stimulating factor ; Subcutaneous injection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A patient with chronic idiopathic neutropenia, who had been suffering from repeated infections, was successfully treated with recombinant granulocyte stimulating factor (rhG-CSF). Subcutaneous injection of 30μg/m2 rhG-CSF every two days was sufficient to maintain the neutrophil count at approximately 1,000/μl. The patient has lived without any evidence of infection for the last 10 months using that treatment. There were no side effect caused by rhG-CSF and antibodies against G-CSF were not detected in the patient's plasma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01714979
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  • 15
    Electronic Resource
    Electronic Resource
    Effects of sciatic neurectomy on the femur in growing rats: Application of peripheral quantitative computed tomography and Fourier transform infrared spectroscopy (1999)
    Springer
    Journal of bone and mineral metabolism 17 (1999), S. 259-265 
    Details
    ISSN: 1435-5604
    Keywords: Key words: sciatic neurectomy ; femur ; peripheral quantitative computed tomography ; Fourier transform infrared spectroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: The effects of unilateral sciatic neurectomy (USN) on the development of the femur were studied in 15 growing Wistar-derived rats (age, 5 weeks). The rats were divided into four groups: USN-operated group (right femur), USN-nonoperated group (left femur), sham-operated group (right femur), and sham-nonoperated group (left femur). Bone mineral density (BMD), bone mineral content (BMC), bone area, periosteal circumference, and endosteal circumference were measured by peripheral quantitative computed tomography (pQCT) and the mineral/matrix ratio was evaluated by Fourier transform infrared spectroscopy (FTIR). The USN-operated group showed a significant decrease in cortical BMC, bone area, and periosteal circumference compared with the other groups (P 〈 0.05). The cortical BMD did not vary significantly between the groups. In the cancellous bone, the USN-operated group showed a significant decrease in BMD and BMC at the metaphysis compared with the other groups (P 〈 0.05). The mineral/matrix ratio of the cortical bone did not differ significantly between the USN-operated and USN-nonoperated groups. These results suggest that in cortical bone, USN inhibits periosteal bone formation but has no significant effect on the mineral/matrix ratio of cortical bone in femurs. In cancellous bone, USN induces bone loss at the metaphysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007740050093
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  • 16
    Electronic Resource
    Electronic Resource
    Risk factors for hepatocellular carcinoma among Japanese women (1995)
    Springer
    Cancer causes & control 6 (1995), S. 91-98 
    Details
    ISSN: 1573-7225
    Keywords: Alcohol drinking ; blood transfusion ; hepatitis B virus ; hepatocellular carcinoma ; females ; smoking ; Japan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: To elucidate the risk factors for hepatocellular carcinoma (HCC) among women, we made a combined analysis of the data from three case-control studies conducted in high-risk areas of Japan. A total of 120 cases and 257 controls were included in the analysis. After adjustment for the study category, age, and other potential confounders, significantly increased risks were associated with chronic hepatitis-B virus infection (odds ratio [OR]=42.4, 95 percent confidence interval [CI]=11.2–160.2), a past history of blood transfusion (OR=3.7, CI=1.8–7.5), and a history of smoking (OR=2.2, CI=12–4.1). In addition, women with a history of heavy drinking experienced an elevated risk of borderline significance (OR=4.2, CI=0.9–20.4, P=0.07). When these ORs were compared with the corresponding estimates among males from the same case-control studies, no significant differences were observed between the two genders. Among the factors examined in this analysis, drinking and smoking habits—which are more common among Japanese men than women—may partly account for a large male-predominance in the incidence of HCC. Further studies are needed to clarify the roles that sex-hormones and hepatitis-C virus infection might play in the large gender difference of HCC occurrence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00052768
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  • 17
    Electronic Resource
    Electronic Resource
    Efficacy of amoldipine besilate therapy for variant angina: Evaluation by 24-hour Holter monitoring (1993)
    Springer
    Cardiovascular drugs and therapy 7 (1993), S. 923-928 
    Details
    ISSN: 1573-7241
    Keywords: amlodipine ; variant angina ; ST elevation ; Holter electrocardiogram ; calcium antagonist
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The efficacy of amlodipine, a calcium antagonist, was investigated in 12 patients with variant angina. Amlodipine was administered at a dose of 5 mg once daily, and efficacy was assessed from the frequency of anginal attacks, the frequency of ST elevation or depression, and the extent of ST segment changes [ST segment elevation or depression (mm) × duration (seconds)] on the Holter ECG before and after treatment. The frequency of ST elevation during the observation period was 1.67 ± 0.33 times/day (symptomatic attacks: 1.17±0.21/day; asymptomatic attacks: 0.50±0.19/day), and this significantly decreased to zero per day (both symptomatic and asymptomatic attacks) after treatment (p〈0.05). The extent of ST segment elevation during the observation period was 507.5±156.6 mm·sec/day (symptomatic: 382.5±102.9 mm·sec/day; asymptomatic: 125.0±62.0 mm·sec/day), and such changes were completely suppressed (both symptomatic and asymptomatic) by treatment (p〈0.05). The frequency of ST depression was 2.08±0.42 times/day (symptomatic: 0.25±0.13/day; asymptomatic: 1.83±0.37/day) during the observation period, while it was 1.50±0.36 times/day (symptomatic: 0.25±0.13/day; asymptomatic: 1.25±0.30/day) after treatment. Although anginal attacks remained unchanged, asymptomatic attacks tended to decrease (p=0.07). The extent of ST depression during the observation period was 632.5±239.4 mm·sec/day (symptomatic: 105.0±64.4 mm·sec/day; asymptomatic: 527.5±189.5 mm·sec/day), and this significantly decreased to 333.8±111.4 mm·sec/day (symptomatic: 50.0±31.2 mm·sec/day; asymptomatic: 283.8±102.6 mm·sec/day) after treatment (p〈0.05). The frequency of anginal attacks during the observation period was 1.27±0.18 times/day, and this significantly decreased to 0.40±0.12/day after 1 week of treatment and to 0.22±0.07/day after 2 weeks of treatment (p〈0.05). These results suggest that amlodipine is effective for treating variant angina at a daily dose of 5 mg.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00877728
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  • 18
    Electronic Resource
    Electronic Resource
    Experimental rat model representing both acute and chronic heart failure related to autoimmune myocarditis (1995)
    Springer
    Cardiovascular drugs and therapy 9 (1995), S. 701-707 
    Details
    ISSN: 1573-7241
    Keywords: autoimmune myocarditis ; heart failure ; hemodynamics ; dobutamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The most important clinical manifestation of myocarditis is congestive heart failure. The precise mechanisms of heart failure during myocarditis have not been elucidated because no animal model that would permit in vivo study of hemodynamics in severe active myocarditis has been available. We monitored hemodynamics and left ventricular function in a rat model of experimental autoimmune myocarditis to determine if this model could be useful for the study of in vivo hemodynamics in severe active myocarditis. Lewis rats were immunized with human cardiac myosin suspended in complete Freund's adjuvant. Baseline hemodynamics were measured using an ultraminiature catheter pressure transducer via the right internal carotid artery, 4 weeks after immunization in one group of rats (acute phase) and 3 months after immunization in another group (chronic phase). Untreated rats served as the control group. Hemodynamic measurements were also obtained after infusion of dobutamine in the acute-phase and chronic-phase groups. The heart weight-to-body weight ratios were significantly higher in both the acute-phase group and the chronic-phase group compared with normal control rats. The baseline left ventricular systolic pressure was significantly lower in the chronic phase group than in the control group. Peak dP/dt and peak -dP/dt were significantly lower in both the acute-phase group and the chronic-phase group compared with the control group. Dobutamine significantly increased left ventricular systolic pressure, peak dP/dt, and peak -dP/dt in the chronic-phase group but caused only minor changes in hemodynamic variables in the acute-phase group. In vivo measurements of hemodynamic variables indicated the presence of left ventricular dysfunction in rats with experimental autoimmune myocarditis. This animal model may be useful for the study of both acute heart failure related to acute myocarditis and chronic heart failure due to diffuse myocardial fibrosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00878553
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  • 19
    Electronic Resource
    Electronic Resource
    Analysis of the global relationship of biennial variation of sea surface temperature and air-sea heat flux using satellite data (1996)
    Springer
    Journal of oceanography 52 (1996), S. 717-746 
    Details
    ISSN: 1573-868X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract We investigated the phase difference and the cross correlation coefficient between the band-pass filtered biennial variations of sea surface temperature (SST) and air-sea heat flux estimated by the monthly mean 2°×2° satellite data of Advanced Very High Resolution Radiometer (AVHRR) and Special Sensor Microwave/Imager (SSM/I) from July 1987 to June 1991. Judging from the phase difference, it can be determined whether the biennial variation of SST is controlled by local thermal air-sea interaction or oceanic processes of horizontal transport. When the local air-sea heat flux controls the biennial variation of SST, the phase of SST advances π/2 (∼6 months) against that of the air-sea heat flux. In contrast, when the biennial variation of SST is controlled by the oceanic process, the phase difference between the SST and the air-sea heat flux becomes 0 or π(∼12 months). In this case, two types of the phase differences are determined, depending on which variability of SST and air-sea heat flux is larger. The close thermal air-sea interaction is noticeable in the tropics and in the western boundary current region. The phase difference of π/2 appears mainly in the north Pacific, the southeast Indian Ocean, and the western tropical Pacific; zero in the eastern tropical Pacific and the northeast and equatorial Atlantic; and that of π in the central equatorial Pacific and north of the intertropical convergence zone (ITCZ) of the Atlantic. Phase differences of 0, π, or π/2 are possible in the western boundary current regions. This fact indicates that each current plays a different role to the biennial variation of SST. It is inferred that SST anomalies in the tropics are mutually correlated, and the process in which marked SST anomalies in the tropics are transferred to the remote area was probed. In the equatorial Pacific, the SST anomaly is transferred by the long planetary wave. On the other hand, it is found from the phase relationship and the horizontal correlation of SST that the SST anomaly in the central and western equatorial Pacific is connected through atmospheric mediation. It is suggested that the biennial variation of SST in the eastern Indian Ocean is affected by heat transport due to the Indonesian throughflow from the western tropical Pacific. It is found that the mentioned pattern of the interannual variation of SST in the tropical Atlantic as a dipole is not tenable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02239462
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  • 20
    Electronic Resource
    Electronic Resource
    Evaluation of Vector Winds Observed by NSCAT in the Seas around Japan (2000)
    Springer
    Journal of oceanography 56 (2000), S. 495-505 
    Details
    ISSN: 1573-868X
    Keywords: NSCAT ; scatterometer ; surface wind vectors ; remote sensing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract In order to validate wind vectors derived from the NASA Scatterometer (NSCAT), two NSCAT wind products of different spatial resolutions are compared with observations by buoys and research vessels in the seas around Japan. In general, the NSCAT winds agree well with the wind data from the buoys and vessels. It is shown that the root-mean-square (rms) difference between NSCAT-derived wind speeds and the buoy observations is 1.7 ms−1, which satisfies the mission requirement of accuracy, 2 ms−1. However, the rms difference of wind directions is slightly larger than the mission requirement, 20°. This result does not agree with those of previous studies on validation of the NSCAT-derived wind vectors using buoy observations, and is considered to be due to differences in the buoy observation systems. It is also shown that there are no significant systematic trends of the NSCAT wind speed and direction depending on the wind speed and incidence angle. Comparison with ship winds shows that the NSCAT wind speeds are lower than those observed by the research vessels by about 0.7 ms−1 and this bias is twice as large for data observed by moving ships than by stationary ships. This result suggests that the ship winds may be influenced by errors caused by ship's motion, such as pitching and rolling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1011192725800
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