ISSN:
1600-0560
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
We report three patients with pemphigoid nodularis. Patients were females aged 76, 71 and 50 years, and all had features of billions pemphigoid together with prurigo-like lesions at some stage of their illness. In two eases, nodular lesions preceded the onset of blistering by some months. Blisters arose on normal skin and in one patient also at sites of prurigo lesions. Routine histology of bullous lesions revealed the presence of subepidermal blisters. Electron microscopy perlormed in two eases confirmed the level of split to be through the lamina lucicla. Direct immunoflourenscence in all eases was positive, with linear basement membrane zone deposition of IgG and G3. Circulating IgG anti-basement membrane antibody was also detected in all patients, and in two, immunoblotting revealed a single antigen of 220 kD.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1600-0560.1992.tb01661.x
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