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  • 11
    Electronic Resource
    Electronic Resource
    Springer
    Pure and applied geophysics 114 (1976), S. 587-592 
    ISSN: 1420-9136
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Summary Mean soundings over different latitude belts of northern tropical atmosphere have been worked out for four seasons. The soundings thus obtained have been used to compute the mean static stability. The investigation of static stability reveals that the lower troposphere in all the seasons are statically stable and conditionally unstable, and the instabilities are more pronounced in summer than in winter. The role of moist static stability in tropical meteorology has been discussed.
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    Springer
    Pure and applied geophysics 118 (1980), S. 990-1006 
    ISSN: 1420-9136
    Keywords: Earthquake source ; Rupture model ; Rupture velocity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Summary Analytic expressions for the far-field displacement both in the time and the frequency domains are obtained for the kinematic earthquake model of a rupture which nucleates at a point, grows in the form of a rectangle and stops at a later time. The spectra ofS andP waves are analyzed with the object of determining fault dimensions from the corner frequencies. The approach by which the solution of the present problem is obtained can be extended to get closed form solutions to the problem of rupture front expanding in the form of a polygon and terminating over a fault area which has the form of another polygon.
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Springer
    Pure and applied geophysics 123 (1985), S. 624-637 
    ISSN: 1420-9136
    Keywords: Monsoon rainfall ; Extended EOF analysis ; 40-day oscillation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The low frequency spatio-temporal intraseasonal evolution of monsoon rainfall over India is studied by considering the pentad rainfall averages taken over 2.5° wide and 5.0° long blocks lying across the central longitudinal and latitudinal transacts. The time-latitude cross sections show south to north progressions of rainfall anomalies with a recurrence period of about 40 days. The progressions show considerable inter-annual and intra-seasonal variation in frequency, amplitude and rate of progression. The extended empirical orthogonal function analysis shows that the first two most important functions correspond to this northward progression of rain anomalies recurring after an interval of about 40 days. The rate of progression of anomalies is about 0.5° Lat./day. The time-longitude cross sections show the movement of rainfall anomalies towards both directions east and the west, with slight preference towards the east. The importance of these signals in rainfall forecasting is foreseen.
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Springer
    Pure and applied geophysics 155 (1999), S. 169-181 
    ISSN: 1420-9136
    Keywords: Key words: 3-D HLEM modeling, tropical weathering, weathered pockets, resistive dykes, semi- weathered layer.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract —In a sand-covered granite terrain of northwestern Rajasthan, India, a five-frequency HLEM survey along a 10-km traverse line generated several clear and strong anomalies. Subjected to a joint constrained 1-D layered earth inversion, the IP and OP frequency soundings at each point of observation yields either no solution or one which is inconsistent with the adjacent point. On the other hand, a 3-D model fitting of these anomalies with a tabular body in a layered host leads to a more meaningful interpretation, suggesting the presence of (1) pockets of weathered conductive material and (2) resistive intruding dykes, embedded in a semi-weathered layer, as the cause of the observed anomalies. The locations of weathered pockets are probably determined by pre-existing weak structures such as joints, fractures and faults, which facilitated movement of groundwater and hence weathering. Thus covered features deep in the bedrock such as intrusives, joints, fractures and faults, which are not directly detectable by the HLEM method, being under a more conductive overburden, are indirectly detected through their imprints left in the overlying weathering profile.
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 44 (1988), S. 782-785 
    ISSN: 1420-9071
    Keywords: Methyl nitrosourea (MNU) ; sister chromatid exchange (SCE) ; aging ; mutagenic sensitivity ; background genotype
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We studied mice from five strains (BALB/c, C3H/HeSnJ, C57BL/6J, Csb and 129/ReJ) at two ages (young, 10±1 weeks; and old, 67±3 weeks) for the induction of sister chromatid exchanges (SCEs) in vivo by methyl nitrosourea (MNU). The SCE frequency is genotype-specific. The F1 phenotype resembles the ‘low’ responding parent. SCE induction is significantly lower in the older animals of each strain than their younger counterparts, and the reduction of SCE/cell with old age is strain-specific. A general explanation for these results must include strain differences in relative mutagenic sensitivity, genotype-specific pattern of reduction in DNA repair and other such factors affecting SCE formation, with old age.
    Type of Medium: Electronic Resource
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  • 16
    ISSN: 1432-0533
    Keywords: Ectopic neurons ; Hippocampus ; Connections ; Methylazoxymethanol acetate ; Treated rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In an earlier study, it was reported that clusters of ectopic neurons developed postnatally in the hippocampus of rats which were exposed to Methylazoxymethanol acetate (MAMac) during fetal development (Singh, 1977b). This paper describes the perforant tract and commissural connections of hippocampal eutopic and ectopic neurons. These connections were traced with a reduced-silver method (Eager, 1970). Two observations of significance were made. (i) Ectopic neurons misplaced in stratum radiatum received terminals from axons in the perforant tract. The upper boundary for these redirected fibers was stratum pyramidale — approximately 350 μ outside the normal boundary which is situated near the hippocampal fissure. (ii) Ecotopic neurons received a dramatically reduced commissured projection, compared with eutopic pyramidal neurons in Ammon's horn. Eutopic neurons in the hippocampus were found to receive afferent perforant tract and commissural fibers in the same way — i.e., density and distribution, as in control rats.
    Type of Medium: Electronic Resource
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  • 17
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 26 (1970), S. 278-280 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Le cœur de grenouille continue à battre de lui-même et répond à une stimulation électrique durant 5–6 h s'il reçoit une injection contenant une demi solution isotonique de saccharose, de pyrophosphate de sodium et d'adénosinetriphosphate ou de citrate de sodium. Le chloride de sodium annule ces deux réactions.
    Type of Medium: Electronic Resource
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  • 18
    ISSN: 1432-1440
    Keywords: Malignant hyperthermia ; Ryanodine receptor gene ; C1840-T mutation ; In vitro contracture test ; Human skeletal muscle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In swine, a point mutation in the ryanodine receptor gene can account for all cases of malignant hyperthermia (MH). The frequency of a corresponding mutation in humans (C1840-T) and its relationship to the in vitro contracture profile is unknown. We screened 192 patients from 28 unrelated northern German families for the C1840-T mutation in the human ryanodine receptor gene and tested for MH susceptibility using the in vitro contracture test (IVCT) according to the European MH Protocol. In our patients 106 revealed MH susceptible (MHS), 56 MH nonsusceptible and 30 MH equivocal status following IVCT. In each family one or two individuals had developed clinical signs of MH or a MH crisis. All of these patients were classified MHS. The C1840-T mutation was found in 2 of 28 families (7.1%). All eight individuals of the two families characterized by this mutation revealed MHS status following IVCT. The thresholds for halothaneand caffeine-induced contractures as well as the contracture profiles following cumulative (0.4–10.0 μmol/l every 3 min) and bolus (10 μmol/l) administration of ryanodine were found to be similar in MHS patients with and without the C1840-T mutation. In conclusion, the C1840-T mutation in the human ryanodine receptor gene is a rare abnormality in MHS families. Similar contracture profiles in the presence and absence of this mutation might imply no major functional role with respect to the contracture response. At present, molecular genetic analysis cannot replace IVCT to discover MH susceptibility in humans.
    Type of Medium: Electronic Resource
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  • 19
    Electronic Resource
    Electronic Resource
    Springer
    Mathematische Annalen 191 (1971), S. 121-142 
    ISSN: 1432-1807
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
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  • 20
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 90 (1993), S. 635-640 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A sample of 114 primary breast tumors and corresponding constitutional DNA were tested for loss of heterozygosity (LOH) of the YNZ22 and p53 genes, both located in the 17p13 region. Loss of the p53 allele was found in 28 of 44 primary breast carcinomas (64%). In contrast LOH in only 26 of 61 tumors (43%) was detected with the variable number of tandem repeats (VNTR) probe YNZ22 mapping at 17p13.3 close to the p53 locus at 17p13.1. Among 19 tumors informative for both probes allele loss at 17p13.3 never occurred without p53 involvement. These data suggest, that p53 is the target of 17p13 allelic deletions in human breast cancer. Immunohistochemistry showed overexpression of the p53 protein in 25 of 50 cases (50%) presumably reflecting activating point mutations. Overexpression was not correlated with allele loss but seemed to be closely related to the presence of point mutations in this study. No homozygous deletions or rearrangements of the p53 gene were detected. This would argue for an important role of heterozygous p53 mutations in human breast cancer.
    Type of Medium: Electronic Resource
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