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  • 11
    Electronic Resource
    Electronic Resource
    Increase in micropore volume of N-containing activated carbon treated with methylol melamine urea solution (1983)
    Springer
    Cellular and molecular life sciences 39 (1983), S. 143-144 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The micropore volume of N-containing activated carbon was increased and the average radius of supermicropore was extended by treatment with methylol melamine urea solution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01958863
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  • 12
    Electronic Resource
    Electronic Resource
    Naloxone prevents the analgesic action of α-MSH in mice (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 627-628 
    Details
    ISSN: 1420-9071
    Keywords: α-MSH ; analgesia ; naloxone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary α-MSH (0.1, 1, 10 μg) was administered intracerebroventricularly and its action on pain sensitivity was investigated by the hot-plate method in mice. α-MSH produced dose-dependent analgesia and this analgesic effect was prevented by naloxone (1 mg/kg, s.c.). It is possible that α-MSH may play a role in the mechanism of pain through endogeneous opioid systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02007691
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  • 13
    Electronic Resource
    Electronic Resource
    Copper metabolism in the LEC rat: Involvement of induction of metallothionein and disposition of zinc and iron (1991)
    Springer
    Cellular and molecular life sciences 47 (1991), S. 1060-1063 
    Details
    ISSN: 1420-9071
    Keywords: LEC rat ; copper ; metallothionein ; ceruloplasmin ; zinc ; iron
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The Cu concentration was about 40 times higher in the liver of LEC (Long-Evans with a cinnamon-like coat color) rats aged 77 days (227.5±21.6 μg/g liver) than in Fischer rats (5.2±0.1 μg/g liver). However, in the kidney and brain of the LEC rats, Cu concentrations were lower than in these organs of the Fischer rats. Cu concentration in the hepatic metallothionein fraction was about 130 times higher in the LEC rats than in the Fischer rats. The LEC rats showed markedly low concentrations of Cu in the serum and bile. It seems likely that excretion of Cu from the liver into the bile and blood (as ceruloplasmin) is inherently lacking in the LEC rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01923342
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  • 14
    Electronic Resource
    Electronic Resource
    Alpha-amylase inhibitor increases plasma 3-hydroxybutyric acid in food-restricted rats (1995)
    Springer
    Cellular and molecular life sciences 51 (1995), S. 585-588 
    Details
    ISSN: 1420-9071
    Keywords: α-amylase inhibitor ; plasma glucose ; 3-hydroxybutyric acid ; high starch diet
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effect on energy metabolism of delayed absorption of starch by inhibition of α-amylase was examined by considering levels of plasma glucose and 3-hydroxybutyric acid (3-OHBA) in rats. Addition of α-amylase inhibitor (αAI) to a high starch diet delayed the plasma glucose response after feeding: peak plasma glucose levels in the control group occurred 15 min after feeding, whereas in the αAI group this peak did not occur until 30 min after. The total plasma glucose response was not different between the two groups. Plasma 3-OHBA levels 1 day after food restriction increased approximately five-fold in both groups. After 3 days of food restriction, the αAI group maintained the same level of plasma 3-OHBA as after 1 day of food restriction, while the control group showed significantly decreased levels of 3-OHBA. After 3 days of food restriction, plasma insulin levels were significantly decreased in the αAI group compared with the corresponding levels of the control group and with levels before the restriction. There was no significant difference in body weight between the two groups. These findings suggest that delayed hyperglycemia due to delayed absorption of starch following αAI loading may attenuate insulin secretion, leading to altered metabolism of 3-OHBA during the delayed response to energy deficit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02128748
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  • 15
    Electronic Resource
    Electronic Resource
    Cyclosporine A-associated fatal central nervous system angiopathy in a bone marrow transplant recipient: an autopsy case (2000)
    Springer
    Acta neuropathologica 99 (2000), S. 680-684 
    Details
    ISSN: 1432-0533
    Keywords: Key words Basilar artery ; Vasoconstriction ; Cyclosporine A ; Bone marrow transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report here the case of a 32-year-old woman who suffered from a unique angiopathy in the central nervous system (CNS). She died of multiple infarcts in the brain stem and cerebellum during treatment with cyclosporine A after bone marrow transplantation for refractory anemia with excess of blasts. The autopsy findings showed segmental narrowing of the basilar artery, in which circumferential dissection of the internal elastic lamina had occurred. The distal portion of the basilar artery was obstructed by upward dislocation of the dissected intima. Similar angiopathy was also observed at multiple sites along the basilar artery branches. These findings suggest endothelial damage, including vasoconstriction and dissection of the CNS arteries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010051179
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  • 16
    Electronic Resource
    Electronic Resource
    Ubiquitinated filamentous inclusions in cerebellar dentate nucleus neurons in dentatorubral-pallidoluysian atrophy contain expanded polyglutamine stretches (2000)
    Springer
    Acta neuropathologica 99 (2000), S. 615-618 
    Details
    ISSN: 1432-0533
    Keywords: Key words Dentatorubral-pallidoluysian atrophy ; Cerebellar dentate nucleus neuron ; Skein-like inclusion ; Polyglutamine ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have recently reported that, in addition to the widespread occurrence of ubiquitinated neuronal intranuclear inclusions (NIIs), the restricted occurrence of ubiquitinated intracytoplasmic filamentous inclusions in the neurons of the cerebellar dentate nucleus (CDN) is a characteristic feature of dentatorubral-pallidoluysian atrophy (DRPLA). Interestingly, these neuronal intracytoplasmic filamentous inclusions (NIFIs) were morphologically indistinguishable from the skein-like inclusions (SLIs) described previously in the spinal anterior horn cells in amyotrophic lateral sclerosis (ALS). In the present study, we examined immunohistochemically the CDN in ten patients with clinicopathologically and genetically confirmed DRPLA and the spinal anterior horns in five patients with sporadic ALS, using a monoclonal antibody (1C2) directed against long polyglutamine stretches. In all of the patients with DRPLA, both the NIFIs and the NIIs were visualized clearly with 1C2. Conversely, in the patients with ALS all structures, including the SLIs, were completely negative. These findings indicate that in DRPLA, the NIFIs in the CDN are an alteration that is directly related to the causative gene abnormality (an expanded CAG repeat encoding polyglutamine) and that, from the molecular point of view, they are distinct from the SLIs in ALS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010051171
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  • 17
    Electronic Resource
    Electronic Resource
    The twitcher mouse: An ultrastructural study on the oligodendroglia (1983)
    Springer
    Acta neuropathologica 59 (1983), S. 159-166 
    Details
    ISSN: 1432-0533
    Keywords: Twitcher mouse ; Oligodendroglia ; Cellular degeneration ; Myelin sheaths ; Globoid cell leukodystrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Morphological alterations of oligodendroglia were investigated in the spinal cord of the twitcher mouse, an authentic murine model of human globoid cell leukodystrophy (GLD) from day 5 to day 45 postnatal (p.n.). Typical inclusions were seen in the perikarya as well as the processes of oligodendroglia after day 10 with increasing frequency. The majority of the inclusions was non-crystalloid but rather needle-like or slender tubular in appearance. Ultrastructural features of cellular degeneration became first noticeable on days 25–30 in the oligodendroglial cytoplasm. These consisted of an increased number of microtubules and/or smooth cisterns, dispersed ribosomes, alteration of endoplasmic reticulum forming stacked lamellae or whorles, vesiculation or vacuolation of cytoplasm. The number of degenerating oligodendroglia increased in the older twitcher mice, so did the degenerating myelin sheath. However, even on day 45, when globoid cells became conspicuous in subpial and perivascular regions, many oligodendroglia and myelin sheaths were still well preserved. These observations suggested that oligodendrogial degeneration resulted in the degeneration of myelin sheaths but globoid cells appeared even before morphological evidence of myelin degeneration, presumably in response to the biochemical alterations resulted from the deficiency of galactosylceramidase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00703199
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  • 18
    Electronic Resource
    Electronic Resource
    Paragangliomas of the craniocervical region (1987)
    Springer
    Acta neuropathologica 73 (1987), S. 227-232 
    Details
    ISSN: 1432-0533
    Keywords: Paraganlioma ; Tyrosine hydroxylase(TH) ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An immunohistochemical study on tyrosine hydroxylase (TH), a rate-limiting enzyme in the catecholamine synthesizing pathway, was made on three cranioncervical region paragangliomas, two of which showed metastases to the cervical lymph nodes. In all of the original tumors, the majority of tumor cells showed positive immunostaining for TH of variable intensity in their cytoplasm regardless of their cytological features such as cellular and nuclear pleomorphism. The finding suggests that most tumor cells are capable of production of catecholamines and are derived from chief cells in the normal paraganglia. In cervical lymph nodes, however, no positive immunostaining for TH was observed in metastatic tumor cells, in contrast with the findings in the original tumors. The absence of TH immunoreactivity in metastatic tumor cells appears to be noteworthy in considering their malignant potential. Application of the TH immunohistochemistry to further cases appears important for the better understanding of this neoplasm, a catecholamine-producing tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686615
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  • 19
    Electronic Resource
    Electronic Resource
    Occurrence of 15-nm-wide straight tubules in neocortical neurons in progressive supranuclear palsy (1989)
    Springer
    Acta neuropathologica 79 (1989), S. 233-239 
    Details
    ISSN: 1432-0533
    Keywords: Progressive supranuclear palsy ; Neocortex ; Neurofibrillary tangles ; Straight tubules ; Twisted tubules
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ultrastructural investigations were carried out on the cerebral neocortex in two cases of progressive supranuclear palsy. In both cases, characteristic 15-nm-wide straight tubules were observed in the neurons. The numbers of cells containing the straight tubules and of tubules in individual cells were small. However, the occurrence of the tubules strongly suggests that the cerebral neocortex is also exposed to the disease process in progressive supranuclear palsy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294656
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  • 20
    Electronic Resource
    Electronic Resource
    Transplacental effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on brain dopaminergic neurons in the mouse (1989)
    Springer
    Acta neuropathologica 79 (1989), S. 279-285 
    Details
    ISSN: 1432-0533
    Keywords: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) ; C57BL/6J mouse ; Tyrosine hydroxylase ; Aromatic l-amino acid decarboxylase ; Dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immunohistochemical studies of monoamme neurons werè performed to evaluate toxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on young adult mice and compare them with chose of their offspring. Mice, 9–11 weeks old (C57BL/6J), injected subcutaneously with a large dose of MPTP (17 mg/kg per day) during pregnancy on Day 9 and 12 of gestation (G9 and G12) miscarried and were examined at 13 weeks of age. Conversely, mice treated during pregnancy with sequential low dose of MPTP (2.8 mg/kg per day at G9–G17 for 8 days) successfully delivered their babies and were examined at the age of 15 weeks. Baby mice were examined at 1 and 6 weeks of age. The tyrosine hydroxylase-, aromatic l-amino acid decarboxylase-and dopamine (DA)-immunoreactive density of caudoputamen was reduced in 13-week-old mice treated with high dose of MPTP but not in the 15-week-old mothers exposed to a low dose of MPTP as compared to their respective controls. The DA-immunoreactive density of the caudoputamen was the only staining that was reduced in both 1- and 6-week-old baby mice. In conclusion, these results demonstrate that MPTP injected to pregnant mice causes a DA depletion in the striatum of their offspring indicating a transplacental effect of MPTP. The findings also indicate that fetal brain is more susceptible to MPTP toxicity than the brain of young pregnant mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294662
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