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  • 11
    Electronic Resource
    Electronic Resource
    Determination of the lithium and rubidium in sea water by double channel flame emission spectrophotometry (1980)
    Springer
    Journal of oceanography 36 (1980), S. 196-200 
    Details
    ISSN: 1573-868X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract A precise and accurate technique for the determination of Li and Rb in sea water has been developed by using a double channel flame emission spectrophotometer. The advantage of this technique is that it is possible to correct the background emission by making use of the double channel system of the apparatus and to obtain constant intensity of emission even if there are large scale changes in the salinity of the sample. Sea water samples collected in the open sea and coastal areas of Japan were analyzed by this method. In one of the coastal areas, an extraordinarily high concentration of Li was found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02070332
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    Paper (German National Licenses)
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  • 12
    Electronic Resource
    Electronic Resource
    Efficacy of Ultrasonic Mass Survey for Abdominal Cancer (1998)
    Springer
    Journal of medical systems 22 (1998), S. 55-62 
    Details
    ISSN: 1573-689X
    Keywords: ultrasonic mass survey ; abdominal cancer ; early detection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract From August 1983 through March 1995, 204,099 people received ultrasonic mass survey of the abdomen for the first time. Among these examinees, 631 (0.31%) malignant neoplasm cases, such as 201 hepatocellular carcinoma (HCC), 81 gallbladder (GB) cancer, 57 pancreatic cancer, and 169 renal cell carcinoma (RCC), were detected. Three hundred seventy six out of 590 cases (64%), excluding chronic leukemia cases and metastatic liver cancer cases, were surgically resected. The resection rate of HCC, GB cancer, pancreatic cancer, and RCC were 25%, 88%, 49%, and 99%, respectively. The cumulative survival rate of the 376 resected cases was 79.5% at 10 years. The cumulative survival rates of resected cases of HCC, GB cancer, pancreatic cancer and RCC were 34% at ten years, 83% at 10 years, 49% at 7 years, and 99% at 10 years, respectively. Ultrasonic mass survey is dramatically useful for early detection of various kinds of abdominal cancers, especially RCC and GB cancer. From now on, many earlier abdominal cancers will be found by establishing and promoting ultrasonic mass survey systems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022634900391
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    Paper (German National Licenses)
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  • 13
    Electronic Resource
    Electronic Resource
    Hepatitis C virus replication is associated with expression of transforming growth factor-α and insulin-like growth factor-II in cirrhotic livers (1996)
    Springer
    Digestive diseases and sciences 41 (1996), S. 208-215 
    Details
    ISSN: 1573-2568
    Keywords: hepatitis C virus ; transforming growth factor-ga ; transforming growth factor-β1 ; insulin-like growth factor-II
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The molecular role of hepatitis C virus (HCV) in liver disease has yet to be clarified. In this study, we analyzed the relationship of HCV replication with mRNA expression of growth factors and mutation of tumor suppressor gene, ie, transforming growth factor-β1 (TGF-β1), which promotes cirrhotic changes; TGF-α, insulin-like growth factor-II (IGF-II), which are both related to hepatocyte transformation; and tumor suppressor genep53, which is associated with HCC progression. A semiquantitative RNA polymerase chain reaction (RNA-PCR) was used to analyze genetic expression in 31 cirrhotic liver specimens from patients with HCV. In order to detect HCV replication, the minus-strand RNA of HCV, which serves as a template for the synthesis of genomic plus-strand RNA, was examined. The expression of the growth factors was semiquantified by RNA-PCR, and the mutation ofp53 was detected using PCR-single-strand conformation polymorphism. According to the semiquantitative analysis, HCV replication was not associated with the expression of TGF-β1 but was significantly so with the overexpression of TGF-α (r=0.74) and IGF-II (r=0.65) in the HCV-positive cirrhotic livers. No mutation ofp53 was recognized in any of the samples. Our investigation thus suggested that the replication of HCV might mediate the coexpression of TGF-α and IGF-II and act as a possible initiating factor for hepatocarcinogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02208606
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  • 14
    Electronic Resource
    Electronic Resource
    Endoscopic treatment of submucosal invasive colorectal carcinoma with special reference to risk factors for lymph node metastasis (1995)
    Springer
    Journal of gastroenterology 30 (1995), S. 710-717 
    Details
    ISSN: 1435-5922
    Keywords: submucosal invasive colon cancer ; lymph node metastasis ; endoscopic treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A clinicopathological analysis of the risk factors for lymph node metastasis was performed in 177 patients with submucosal invasive colorectal carcinoma (CRC). The submucosal deepest invasive portion was histologically subclassified as well (W), moderately (M), or poorly (Por) differentiated. M type was further subdivided into moderately-well (Mw) and moderatelypoorly (Mp) differentiated. The pattern of tumor growth was classified as polypoid growth (PG) and non-polypoid growth (NPG). Lymph node metastasis was detected in 21 (12%) of the 177 patients. Macroscopically, type IIc and IIa+IIc lesions showed a significantly higher incidence of lymph node metastasis (44% and 30%) than type IIa and I (4% and 8%). Regarding the histologic subclassification, Por and Mp lesions showed a significantly higher incidence of lymph node metastasis (67% and 37%) than W and Mw lesions (4% and 14%). NPG tumors showed a significantly higher incidence of lymph node metastasis (29%) than PG tumors (7%). The depth of submucosal invastion and lymphatic invasion (ly) were also significantly correlated with incidence of lymph node metastasis (submucosal scanty (sm-s) invasion 4%, massive invasion 20%; ly(+) 23%, ly(−) 5%). None of the lesions with both sm-s invasion and of W or Mw type showed lymph node metastasis. These results indicate that submucosal invasive CRC with both sm-s invasion and of W or Mw type, which shows no ly, is the appropriate indication for endoscopic curative treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02349636
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    Paper (German National Licenses)
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