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  • 11
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 64 (1992), S. 1845-1850 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 121-123 (Mar. 2007), p. 575-578 
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Notes: Our experiments highlight that gold-silicon eutectics are fairly influenced by the thicknessof Au layer and the wastage of Si, i.e. the wasting thickness of the silicon die. In the experiments, abonding intensity testing method, called Press-arm model, is used to verify the Au-Si eutecticsbonding strength. Through the intensity value of the bonding interface, we analyze the eutecticscondition of the bonding interface at different temperatures and discuss the optimum procession ofthe wafer capsulation
    Type of Medium: Electronic Resource
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  • 13
    ISSN: 1432-0428
    Keywords: Keywords Maturity-onset diabetes of the young ; MODY ; transcription factor ; nuclear receptor ; HNF-4γ ; diabetes mellitus ; insulin ; genetics ; mutation.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Mutations in the transcription factor hepatocyte nuclear factor (HNF)-4α are the cause of one form of maturity-onset diabetes of the young, MODY1. The HNF-4γ is structurally related to HNF-4α and is expressed together with HNF-4α in pancreatic islets. We therefore tested the hypothesis that genetic variation in the HNF-4γ gene (HNF4G) is associated with MODY in Japanese subjects. Methods. We screened the protein coding region of HNF4G (exons 3–11) for mutations in 57 unrelated Japanese subjects with MODY by amplifying each exon and adjacent intron region using the polymerase chain reaction (PCR) and specific primers and then directly sequencing the PCR products. The frequency of each variant was compared between patients with MODY and a group of non-diabetic subjects. Results. We found ten sequence variants, two of these were located in exons: exon 6, a silent substitution in codon 144, c.432A/G and exon 7, a G-to-A substitution in codon 190 (c.570G/A) resulting in a conservative Met-to-Ile substitution (M/I190) in the putative ligand-binding region of HNF-4γ protein. The remaining eight variants were located in introns. There was no significant difference in the frequency of these polymorphisms between subjects with MODY and non-diabetic control subjects. Conclusion/interpretation. Genetic variation in the coding region of HNF4G is unlikely to be a major cause of MODY in Japanese people. [Diabetologia (2000) 43: 1064–1069]
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Springer
    Discrete & computational geometry 20 (1998), S. 515-521 
    ISSN: 1432-0444
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract. In [4] a conjecture concerning the connectivity of mixed cells of subdivisions for Minkowski sums of polytopes was formulated. This conjecture was, in fact, originally proposed by Pedersen [3]. It turns out that a positive confirmation of this conjecture can substantially speed up the algorithm for the ``dynamical lifting'' developed in [4]. In the mean time, when the polyhedral method is used for solving polynomial systems by homotopy continuation methods [2], the positiveness of this conjecture also plays an important role in the efficiency of the algorithm. Very unfortunately, we found that this conjecture is inaccurate in general. In Section 1 a counterexample is presented for a general subdivision. In Section 2 another counterexample shows that even restricted to ``regular'' subdivisions induced by liftings, this conjecture still fails to be true.
    Type of Medium: Electronic Resource
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  • 15
    ISSN: 1432-0568
    Keywords: Guinea-pig ; Intestine ; Submucous ganglia ; NADPH-diaphorase ; Vagotomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The reduced nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) activity in the axon terminals presynaptic to the submucous neurons of guinea-pig intestine following unilateral cervical vagotomy was studied by electron microscopy. The reaction product of diaphorase was localized only in the axon terminals that contained predominantly small agranular vesicles, and it was usually deposited around the vesicles. The terminals that contained predominantly large granular or flattened vesicles did not display any signs of diaphorase reactivity. Although there were only few diaphorase-positive submucous neurons in the small intestine, a considerable number of diaphorase-positive axon terminals was observed in the submucous ganglia of the small intestine in the control animals. Ten days after vagotomy, the quantitative study showed that when compared with the control animals, the number of diaphorase-positive terminals in the submucous ganglia of duodenum, mid-small intestine and colon in the vagotomized animals was reduced (P〈0.05). When the NADPHd-positive terminals were examined in closer detail, it was found that only a small proportion of them showed signs of degeneration as evidenced by the swelling and vacuolation of their contents of mitochondria, with disrupted cristae and clumping of synaptic vesicles. It was therefore concluded that at least some of the diaphorasepositive axon terminals in the submucous ganglia of guinea-pig intestine originated from the vagus nerve.
    Type of Medium: Electronic Resource
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  • 16
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 79 (1989), S. 176-182 
    ISSN: 1432-0533
    Keywords: Histochemistry ; Lectins ; Gliomas ; Macrophages
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Formalin-fixed and paraffin-embedded specimens of 24 human gliomas were examined histochemically with five lectins: concanavalin A (Con A), wheat germ agglutinin (WGA), Ricinus communis agglutinin 1 (RCA-1), peanut agglutinin (PNA), and Ulex europaeus agglutinin 1 (UEA-1). Although the staining intensity with lectins was variable, tumor cells in five astrocytomas, three oligodendrogliomas, six ependymomas, and one gliosarcoma, were generally positive for Con A, WGA, and RCA-1, and negative for PNA and UEA-1, whereas those in nine glioblastomas were usually positive for Con A and WGA and negative for RCA-1 and PNA as well as UEA-1. The malignancy in neoplastic astrocytes was correlated with the decrease in binding with lectins, especially RCA-1. Blood vessels, particularly the endothelial layers, in all gliomas were stained intensely with all lectins used. Macrophages showed two staining features with lectins; stippled and granular. The former macroplìages were positive for Con A, WGA, RCA-1, and PNA, and negative for UEA-1, whereas the latter macrophages were positive for all lectins used. Thus, the staining characteristics with lectins of macrophages were different from those of any glioma cells and very useful for identification of macrophages in gliomas.
    Type of Medium: Electronic Resource
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  • 17
    Electronic Resource
    Electronic Resource
    Springer
    Environmental geology 36 (1998), S. 277-284 
    ISSN: 1432-0495
    Keywords: Key words Soil ; Trace element ; Alluvial plain ; China
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract  A study investigating the contents of 13 trace elements and the correlations between these trace elements and soil parameters of the surface soils in the eastern alluvial plains of China is summarized and discussed in this paper. The results show that the contents of some elements studied differ from region to region. Close relations have been noted between all the trace element contents in the soils of the eastern alluvial plains and the relevant surface materials of erosion regions, which demonstrate the effects of parent materials, while climatic conditions and human interventions are also found to be important factors. Close relations were found between the transition elements of the Quaternary period and the chalcophile elements (except Cu). The chemical and geochemical properties of these elements are identified as beeing important inherent characteristics that affect the relations of these elements in the soils.
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    Springer
    Mathematische Annalen 311 (1998), S. 11-26 
    ISSN: 1432-1807
    Keywords: Mathematics Subject Classification (1991): 14M15, 81T99
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
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  • 19
    Electronic Resource
    Electronic Resource
    Springer
    Mineralium deposita 32 (1997), S. 505-519 
    ISSN: 1432-1866
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The Sanbaqi uranium deposit in Hunan Province, south China, is the largest of a group of paleokarst-hosted uranium deposits in Lower Carboniferous limestone. Mineralization is localized in cavities and fault-breccias formed by dissolution of carbonates. Four episodes of karst formation are recognized: late Triassic-early Jurassic, late Jurassic-early Cretaceous, Cretaceous-Tertiary and Recent. Field relations indicate that the main uranium mineralization is related to the second karst episode. This is supported by isotopic ages of two pitchblende samples at 129 Ma and 134 Ma, as indicated by their nearly concordant data points on concordia plot. These ages are in the time range of the early Yanshanian tectonic movements that affected southern China, and the faulting related to the movements likely triggered the mineralization process at the Sanbaqi deposit. Associated minerals include pyrite, millerite, ullmannite, niccolite, molybdenite, chalcopyrite, sphalerite, galena, calcite and dolomite. Fluid inclusion studies on calcite reveal that temperature of ore deposition was from 181° to 150 °C. The δ18O and δD values of the ore fluids range from 1.5 to 7.9 per mil and from −30.4 and −54.8 per mil, respectively. The mineralogical, fluid inclusion and isotopic data indicate that the minerlization took place in episodic pulses of hydrothermal fluids that were introduced along a set of ring faults. Mobilization and redeposition of earlier formed ore minerals in an open system added to the complexity of the paragenetic sequence. Younger episodes of mineralization occurred during the later karst events as suggested by the geological and additional pitchblende U-Pb isotopic data, during the Cretaceous-Tertiary late Yanshanian tectonic movements and recently. Finally, a comparison of the Sanbaqi uranium deposit with the uranium deposits hosted by solution collapse breccia pipes of the Colorado Plateau, USA, shows that they have many similarities.
    Type of Medium: Electronic Resource
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  • 20
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We detected the loss of a MspI restriction site by a C to T transition at +83 bp and a G to A transition at +84 bp of the 5′-end non-coding region of the human apolipoprotein AI gene. This base change occurred at the “hot spot” (CCGG) for methylation, which may be important in the regulation of gene expression. The population frequency for the loss of the MspI site is 6.1%.
    Type of Medium: Electronic Resource
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