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  • 11
    Electronic Resource
    Electronic Resource
    Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts (1999)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 401 (1999), S. 670-677 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Id proteins may control cell differentiation by interfering with DNA binding of transcription factors. Here we show that targeted disruption of the dominant negative helix–loop–helix proteins Id1 and Id3 in mice results in premature withdrawal of neuroblasts from the cell cycle and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/44334
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  • 12
    Electronic Resource
    Electronic Resource
    A Radial Basis Function Neural Network Multicultural Factors Evaluation Engine For Product Concept Development (2001)
    Oxford, UK and Boston, USA : Blackwell Publishers Ltd
    Expert systems 18 (2001), S. 0 
    Details
    ISSN: 1468-0394
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Computer Science
    Notes: In recent years, new product development (NPD) has become more and more competitive and globalized. In order to succeed in the global marketplace, it is imperative to take multicultural factors into serious consideration during the stage of product concept development. Generally, the voice of customers has been treated as a starting point to downstream product definition and design metrics determination in developing new product concepts. As a result, the elicitation, representation and management of customer requirements will determine the success level of an organization's NPD efforts. Therefore, multicultural factors, also known as the ‘macro’ perspective in the business environment, are the most significant imperatives for organizations to handle, especially in the current trend of globalization. In practice, there are few holistic and promising systems for multicultural factor evaluation in customer requirements. This work aims at realizing a prototype system that combines the strengths of the laddering technique and the radial basis function neural network for customer requirements acquisition and multicultural factor evaluation. The performance of the prototype system is illustrated by using a case study on the design of a refrigerator. The results obtained from the case study are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/1468-0394.00177
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  • 13
    Electronic Resource
    Electronic Resource
    A Web-enabled product definition and customization system for product conceptualization (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Expert systems 22 (2005), S. 0 
    Details
    ISSN: 1468-0394
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Computer Science
    Notes: Abstract: Owing to rapidly changing customer needs and much shorter product life cycles, for developing a successful product it is imperative to employ more efficient and flexible approaches for product conceptualization. To meet this demand, a Web-enabled product definition and customization system (PDCS) is proposed, from a design-knowledge-handling viewpoint, in this paper. It comprises two phases, namely product definition based on the laddering technique and a novel design knowledge hierarchy, and product customization based on an integrated methodology of conjoint analysis and Kohonen association techniques. Basically, this system is a method of conducting design decision-making via customer involvement, i.e. a strategy for transforming customer preference into a specific product concept. A case study on wood golf club design is used to illustrate and validate the proposed Web-enabled PDCS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1468-0394.2005.00315.x
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  • 14
    Electronic Resource
    Electronic Resource
    Convective heat and mass transfer from a falling film to a laminar gas stream (1993)
    Springer
    Heat and mass transfer 29 (1993), S. 79-87 
    Details
    ISSN: 1432-1181
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Description / Table of Contents: Zusammenfassung Die Studie bezieht sich auf den Wärme- und Stoffaustausch von einem Fallfilm an einen laminaren Gasstrom zwischen zwei senkrechten Platten. Der Einfluß der Kopplung zwischen Gas- und Flüssigkeitsphase, von variablen thermophysikalischen Stoffwerten sowie der Filmverdampfung wurden berücksichtigt und der gleichzeitige Massen-Impuls- und Wärmeaustausch zwischen Flüssigkeitsfilm und Gas durch gemeinsame Lösung der das Verhalten der beiden Phasen bestimmenden Gleichungen numerisch untersucht. Dies gilt auch bezüglich der Einflüsse von Flüssigkeitszulauftemperatur und -Mengenstrom auf die Kühlung des Films für Luft/Wasser- und Luft/Ethanolsysteme. Die Ergebnisse belegen, daß der Wärmeübergang von der Gas-Flüssigkeitsgrenze an den Gasstrom vorrangig durch die bei der Filmverdampfung eingespeicherte latente Wärme bestimmt wird. Weiter zeigt sich eine Verbesserung des Filmkühlungsprozesses bei Systemen mit höherer Flüssigkeitszulauftemperatur oder niedrigem Flüssigkeitsstrom.
    Notes: Abstract A numerical study has been made of convective heat and mass transfer from a falling film to a laminar gas stream between vertical parallel plates. The effects of gas-liquid phase coupling, variable thermophysical properties, and film vaporization have been considered. Simultaneous mass, momentum and heat transfer between liquid film and gas stream is numerically studied by solving the respective governing equations for the liquid film and gas stream together. The influences of the inlet liquid temperature and liquid flowrate on the cooling of liquid film are examined for air-water and air-ethanol systems. Results show that the heat transfer from the gas-liquid interface to the gas stream is predominantly determined by the latent heat transfer connected with film evaporation. Additionally, better liquid film cooling is noticed for the system having a higher inlet liquid temperature or a lower liquid flowrate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01560076
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  • 15
    Electronic Resource
    Electronic Resource
    Processing of Calcium Phosphate Porous Materials by 'Self-Setting' (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 280-283 (Feb. 2007), p. 1563-1566 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Macroporous biomaterials based on a-tricalcium phosphate (a-TCP) bone cement with porous structures suitable for implantation purposes were prepared in the present work. According to the reversible swelling/deswelling behavior of gelatin at a single temperature or pH, a “self-setting” method that uses gelatin granules as pore formers was developed to process the porous microstructure. By mixing gelatin powder and bone cement powder (BCP), and adding water (1% solution of NaH2PO4×HO) to form pastes which set within 15 to 30 min, this setted cement was then immerged in deionized water of temperature 25°C or 32°C for hydration. During the hydration, the pH of deionized water after cement pastes were introduced at 32°C changed from 8.6 to 7.2 which caused by the transformation of a-TCP to hydroxyapatite (HA). Meanwhile, gelatin particles will swell by water uptake to form large size spheres in cementmatrix. This swelling behavior is sensitive to the variation of pH value. After hydration for 4 day, a body containing gelatin gel spheres was obtained. Then heating the deionized water to temperature 50°C, gelatin spheres in cement matrix were solved and porous microstructure composed of larger pore sizes corresponding approximately to the average size ofthe swelling gelatin granules was obtained. The porous bodies by this technique were found to have tractable and interconnected porosity in the range of 60~84%, with typical pore sizes ranging from 100~300 microns. This new processing technique can be used in the manufacture of unsintered biomaterials
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.280-283.1563.pdf
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  • 16
    Electronic Resource
    Electronic Resource
    Development of Nanophase β-Tricalcium Phosphate/Collagen Fiber Composites for Improving Cell Adhesion and Proliferation (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 309-311 (May 2006), p. 581-584 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A novel porous beta-tricalcium phosphate /collagen fibers (β-TCP/CF) composite, having a well-dispersed nano-sized β-TCP in collagen matrix, was developed by a wet-chemical method. The nano-composite was compared to conventional β-TCP on cytocompatibility by cell attachment, proliferation, alkaline phosphotatse (AKP) activity and scanning electron microscopy (SEM) analysis. These in vitro assays showed that the β-TCP/CF composite elicited cell adhesion andproliferation better then controls. Moreover experiments on osteoblast-like cells showed improved cell growth with the highly characterized nanophase structure. SEM micrographs also showed that the nano-sized composite exhibited much more viable cells in attachment on the surface compared with the controls. At 1, 3 and 5 days, AKP activity was not significant different for the tested andcontrol samples, while at 7 day after culture, significantly increased AKP activity was observed for β-TCP/CF than for the control. The in vitro results obtained confirmed the remarkable improvement of cell adhesion and proliferation of the nano-sized β-TCP/CF composite, which may be a new promising candidate for tissue engineered bone substitute
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/51/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.309-311.581.pdf
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  • 17
    Electronic Resource
    Electronic Resource
    A Prototype Recombinant Vaccine Against Respiratory Syncytial Virus and Parainfluenza Virus Type 3 (1994)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 12 (1994), S. 813-818 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have produced a genetically-engineered chimeric protein composed of the external domains of the respiratory syncytial virus (RSV) fusion (F) protein and the parainfluenza virus type 3 (PIV-3) hemagglutinin-neuraminidase (HN) protein in insect cells using the baculovirus expression system. The ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0894-813
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  • 18
    Electronic Resource
    Electronic Resource
    Biological Behavior of Nano-Sized Zinc Containing Tricalcium Phosphate Coating on Titanium Alloys (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 309-311 (May 2006), p. 735-738 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/51/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.309-311.735.pdf
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  • 19
    Electronic Resource
    Electronic Resource
    Nano-Calcium Phosphate/PLLA Incorporated with bFGF as In Situ-Transplantable Carrier for Cartilage Regeneration (2006)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 309-311 (May 2006), p. 953-956 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A novel composite of biodegradable Poly-L-lactic acid (PLLA) with the deposition of the nanosized amorphous calcium phosphate (NCP) particles was developed as tissue engineering scaffold. To improve the minor intrinsic healing capacity of cartilage tissue, the porous composite with desired degradation rate was incorporated with basic fibroblast growth factor (bFGF) andevaluated in the in vivo environment. Full-thickness defects were created in the weight-bearing surface of the femoral condyles in a rabbit model. The defect was filled with and without NCP/PLLA scaffold as a carrier of bFGF. Gross morphology for the test implant showed that the defect was filled with regenerated tissue. It resembled cartilaginous tissue and restored the contour of the condyle at 8 weeks after operation. For the untreated control, no cartilage-like tissue wasobserved at all defects. Histological analysis revealed neochondrogenesis and clusters of cartilaginous extracellular matrix observed with safranin-O staining at 4 weeks for the NCP/PLLA with bFGF treated defects. At 8 weeks after operation, well-formed and mature cartilage was resurfaced the defects. While only fibrous tissue replacement was observed for the control either at4 or 8 weeks. Special staining for cartilage indicated the presence of highly sulfatedglycosaminoglycans and collagen, which were the major extracellular matrices of cartilage. This investigation showed the potential of NCP/PLLA loaded with bFGF in the study of in situ-transplantable carrier to improve healing of cartilage tissue lesion
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/51/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.309-311.953.pdf
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  • 20
    Electronic Resource
    Electronic Resource
    Pressureless Sintering the Al〈sub〉2〈/sub〉O〈sub〉3〈/sub〉/SiC Nanocomposites in Deoxidized Atmosphere (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 280-283 (Feb. 2007), p. 1093-1096 
    Details
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Many significant improvements have been shown in mechanical properties of ceramic nanocomposites with ceramic matrix being dispersed with second sub-micro sized (or nano-sized) phase. This study designed and fabricated Al2O3/SiC nanocomposites with a raw material used for 85% alumina as matrix andSiC grits in submicro-scale as dispersion phase via a controlled pressureless sintering in air. With coarse SiC powder as bed powder, both C and SiC powder making deoxidized atmosphere, 85Al2O3/SiC nanocomposites with different SiC contents were densified by pressureless sintering at low temperature. Fracture surface investigation indicated that dense nanocomposites with small grain size were produced. General material properties and microstructure were measured and characterized. The results showed that composites sintered in deoxidized atmosphere had better mechanical properties than those sintered in flowing argon
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/01/49/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.280-283.1093.pdf
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