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  • 21
    Electronic Resource
    Electronic Resource
    Role of intermediate products of prothrombin proteolysis by thrombin in stimulation of the anticlotting system (1976)
    Springer
    Bulletin of experimental biology and medicine 82 (1976), S. 1462-1464 
    Details
    ISSN: 1573-8221
    Keywords: prothrombin ; intermediate products 1 and 2 ; second anticlotting system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Two components were isolated from the products of proteolysis of prothrombin by immobilized thrombin: intermediate product 1 (P1) which, under suitable conditions, can be transformed into thrombin, and product 2 (P2), which does not have this property. After intravenous injection of P1 into rats the total clotting time and the plasma recalcification time were lengthened. The total fibrinolytic activity (TFA) and the level of fibrinogen degradation products were raised, the fibrinogen concentration was lowered, and the degree of nonenzymic fibrinolysis and its contribution to TFA rose sharply. Mobilization of the anticoagulant and fibrinolytic potential of the body was due to the response of the second anticlotting system. Intravenous injection of P2 or prothrombin into rats did not stimulate this system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00799778
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    Paper (German National Licenses)
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  • 22
    Electronic Resource
    Electronic Resource
    Activation of the anticlotting system by prethrombin 2, a thrombin precursor (1980)
    Springer
    Bulletin of experimental biology and medicine 89 (1980), S. 253-255 
    Details
    ISSN: 1573-8221
    Keywords: prethrombins 1 and 2 ; anticlotting system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Prethrombin 2, the direct precursor of thrombin, was obtained by restricted proteolysis of prethrombin 1 by trypsin or by active factor X. In the absence of enzymes, prethrombin 1 is not converted into prethrombin 2. Factor V was shown not to affect the rate of thrombin generation from prethrombin 2. It was shown that prethrombin 2 has no intrinsic coagulating or esterase activity. After intravenous injection of preparations of prethrombin 2, the plasma recalcification time was lengthened and total fibrinolytic activity and nonenzymic fibrinolysis were increased. A considerable increase also was found in the activity of the fibrinogen-heparin complex. These results are evidence of excitation of the anticlotting system by intravenous injection of small doses of prethrombin 2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00834219
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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