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  • 21
    Electronic Resource
    Electronic Resource
    Familial amyloidotic polyneuropathy (ATTR Ser50Ile): the first autopsy case report (2000)
    Springer
    Virchows Archiv 436 (2000), S. 345-350 
    Details
    ISSN: 1432-2307
    Keywords: Key words Amyloidosis ; ATTR Ser50Ile ; Autopsy ; Familial amyloidotic polyneuropathy ; Transthyretin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We report an autopsy case of a pedigree of familial amyloidotic polyneuropathy (FAP) with a mutation of isoleucine-50 transthyretin (ATTR Ser50Ile). A 47-year-old man started developing severe diarrhea and weight loss at age 41 years, followed by urinary incontinence, autonomic-nervous-system abnormalities and serious heart failure; the diagnosis of FAP (ATTR Ser50Ile) was made on the basis of genetic, histochemical and immunohistochemical analysis. Six years after the initial symptoms, he died of septic shock. Autopsy revealed suppurative peritonitis, perforation of the sigmoid colon and marked systemic amyloid deposition. The total amount of amyloid deposited in the heart was greatly increased and was much lower in the thyroid gland and kidneys compared with amyloid deposits in ordinary FAP (ATTR Val30Met). Amyloid deposition in peripheral vessel walls was prominent, particularly in lymphatics and veins. His elder sister, 54 years old, started to develop orthostatic hypotension at age 49 years, followed by dysesthesia, diarrhea and severe congestive heart failure. Endomyocardial biopsy revealed severe TTR–amyloid deposition; ultrastructural examination demonstrated that amyloid fibrils were deposited disproportionately and extended radially around microvessels. These characteristic patterns of systemic amyloid deposition and distinct clinical manifestations, especially in the cardiovascular system, are considered to be a characteristic feature of ATTR Ser50Ile amyloidosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280050457
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  • 22
    Electronic Resource
    Electronic Resource
    Increased soluble IL-2 receptor in serum of patients with systemic lupus erythematosus (1993)
    Springer
    Clinical rheumatology 12 (1993), S. 204-209 
    Details
    ISSN: 1434-9949
    Keywords: sIL-2R ; sCD4 ; sCD8 ; SLE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We estimated the concentration of soluble IL-2R (sIL-2R) in the serum of patients with systemic lupus erythematosus (SLE) and examined the relationship between the serum levels of sIL-2R and clinical features or laboratory data. We found that elevated levels of sIL-2R were present in the serum of SLE patients with discoid rash, and sIL-2R concentrations were correlated with the soluble CD4 and soluble CD8 concentrations but not with classical serological marker, anti-DNA antibody or complement titer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02231527
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  • 23
    Electronic Resource
    Electronic Resource
    Inhibitory effect of anti-allergic agent NCO-650 on histamine release induced by various secretagogues (1988)
    Springer
    Inflammation research 25 (1988), S. 17-21 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Histamine release from rat peritoneal mast cells induced by antigen and anti-IgE was essentially complete within 2 min and 3 min, respectively, but that due to Concanavalin A (Con A) was complete only within 9 min. An anti-allergic agent NCO-650 [trans-4-Guanidinomethylcyclohexanecarboxylic acid p-tert-butylphenyl ester hydrochloride], which is a strong inhibitor of trypsin, dose-dependently inhibited anti-IgE-induced histamine release from rat peritoneal mast cells. Moreover, the rate and extent of histamine release from rat peritoneal mast cells induced by various histamine liberators such as antigen, concanavalin A, ionophore A 23187 and compound 48/80 are significantly diminished in samples incubated with NCO-650. The IC50 values of NCO-650 on histamine release induced by antigen, anti-IgE, Concanavalin A, A23187 and compound 48/80 were in the order of micromolar range, i.e. 1.9, 3.6, 4.6, 2.9 and 6.1 μM, respectively. On a molecular basis, NCO-650 is 1000-fold more potent than DSCG, an anti-allergic drug, in inhibiting the antigen-induced histamine release. The present results suggest that the effect of NCO-650 might be due to the inhibition of a common process underlying the release of histamine by various histamine liberators.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01969088
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  • 24
    Electronic Resource
    Electronic Resource
    Mechanism of inhibition of IgE-dependent histamine release from rat mast cells by xestobergsterol A from the Okinawan marine spongeXestospongia bergquistia (1993)
    Springer
    Cellular and molecular life sciences 49 (1993), S. 145-149 
    Details
    ISSN: 1420-9071
    Keywords: Xestobergsterol A ; histamine release ; PI-PLC ; IP3 ; signal transduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Histamine release from rat peritoneal mast cells induced by anti-IgE was essentially complete within 4–5 min. Xestobergsterol A and B, which are constituents of the Okinawan marine spongeXestospongia bergquistia Fromont, dose-dependently inhibited anti-IgE-induced histamine release from rat mast cells. The IC50 values of xestobergsterol A and B for histamine release in mast cells activated by anti-IgE were 0.07 and 0.11 μM, respectively. Anti-IgE stimulated PI-PLC activity in a mast cell membrane preparation. Xestobergsterol A dose-dependently inhibited the generation of IP3 and membrane-bound PI-PLC activity. Moreover, xestobergsterol A inhibited Ca2+-mobilization from intracellular Ca2+-stores as well as histamine release in mast cells activated by anti-IgE. On the other hand, xestobergsterol B did not inhibit the membrane-bound and cytosolic PI-PLC activity, IP3 generation or the initial rise in [Ca2+]i in mast cells activated by anti-IgE. These results suggest that the mechanism of inhibition by xestobergsterol A of the initial rise in [Ca2+]i, of the generation of IP3, and of histamine release induced by anti-IgE, was through the inhibition of PI-PLC activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01989419
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  • 25
    Electronic Resource
    Electronic Resource
    Dielektrische Untersuchungen an Azetylzellulose in verschiedenen Lösungsmitteln (1941)
    Springer
    Colloid & polymer science 94 (1941), S. 312-318 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Zusammenfassung Es wird die spezifische Polarisation von Azetylzellulose in verschiedenen Lösungsmitteln bestimmt. Die Dichte wie der Brechungsindex ändern sich bis zu den höchsten gemessenen Konzentrationen in allen untersuchten Lösungsmitteln linear. Die Dichte der Azetylzellulose ergibt sich bei Extrapolation auf 100 Proz. zu 1,301 der Brechungskoeffizient zu 1,485.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01520788
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  • 26
    Electronic Resource
    Electronic Resource
    Über die Konzentrationsabhängigkeit der Viskosität bei Azetylzellulose (1941)
    Springer
    Colloid & polymer science 95 (1941), S. 207-211 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01521461
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  • 27
    Electronic Resource
    Electronic Resource
    Über die Konzentrationsabhängigkeit der Viskosität bei organischen Hochpolymeren (1941)
    Springer
    Colloid & polymer science 95 (1941), S. 322-326 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Zusammenfassung Es wird eine Korrekturformel zur 8. Potenzformel von Philippoff-Heß vorgeschlagen, die auch die Fälle gut wiedergibt, wo die einfache 8. Potenzformel ebenso wie andere Viskositätsgleichungen bisher versagten. Im einzelnen wird die Gleichung geprüft an folgenden bisherigen „Ausnahmen“: Cellit in Eisessig (Philippoff-Heß), polymereω-Hydroxydekansäuren in sym-Tetrachloräthan(Kraemer-von Natta), polymere Polystyrole in Benzol (Daneš). In jedem Falle stellen diek-Werte gute Konstanten dar. Die „charakteristische Viskositätskonstante“k zeigt eine lineare Zunahme mit dem Molekulargewicht der Polymerhomologen. Die Temperaturabhängigkeit vonk unda wird geprüft.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01511873
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  • 28
    Electronic Resource
    Electronic Resource
    Assoziation und Solvatation bei Azetylzellulose, nach dielektrischen Messungen (1941)
    Springer
    Colloid & polymer science 96 (1941), S. 336-340 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Zusammenfassung 1. Die spezifische Polarisation von Azetylzellulose in Dioxan wird gemessen. Sie zeigt eine Abnahme mit der Konzentration. 2. Die Konzentrationsunabhängigkeit der Polarisation von Azetylzellulose in Dipollösungsmitteln wird diskutiert. Sie wird erklärt 1. auf Grund einer Konzentrationskonstanz der Solvatation und 2. auf Grund einer Assoziationshemmung durch Solvatation mit polaren Lösungsmittelmolekülen. 3. Die spezifische Polarisation in AzetonMethanol-Gemischen wird gemessen und gleichfalls konstant gefunden. 4. Es werden neue Solvatationszahlen für Azetylzellulose mitgeteilt, die zwischen 3 und 6 Lösungsmittelmolekülen pro 1 C6-Gruppe liegen. 5. Es wird ein kurzer Hinweis gegeben, bei der Solvatation der Azetylzellulose sowohl chemische wie physikalisch-statistische Wirkungen zu berücksichtigen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01502044
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  • 29
    Electronic Resource
    Electronic Resource
    Über den Lösungszustand von Hochpolymeren (1942)
    Springer
    Colloid & polymer science 98 (1942), S. 312-318 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Zusammenfassung 1. Die Löslichkeit von Zellulosederivaten (z. B. Nitrozellulose, Azetylzellulose sowie gemischter Nitroazetylzellulosen) wurde unter dem Gesichtspunkt der Abhängigkeit von Dipolmoment, Dielektrizitätskonstante und Oberflächenspannung der Lösungsmittel betrachtet. Es wird hierzu die von Takei-Erbring aufgestellte Funktionμ 2/ɛσ benutzt, die eine Aussage gestattet über das Lösungsgebiet der einzelnen Zelluloseester. So löst sich Azetylzellulose in Lösungsmitteln kleinerμ 2/ɛσ-Werte, Nitrozellulose dagegen in Gebieten großerμ 2/ɛσ-Werte, so daß von der Triazetyl- zur Trinitrozellulose ein durchaus systematisch sich verschiebendes Lösungsband beobachtet wird. Dinitrozellulose und Diazetylzellulose besitzen bei mittleren Werten ein gemeinsames Lösungsgebiet. 2. Um den Übergang der Löslichkeit von Azetylzellulose zur Nitrozellulose noch näher zu betrachten, wurden verschiedene Nitroazetyizellulosen hergestellt. Die hiermit durchgeführten Löslichkeitsuntersuchungen beweisen, daß eine regelmäßige Löslichkeitsverschiebung besteht, derart, daß der Zelluloseester um so leichter in Lösung geht in Lösungsmitteln großerμ 2/ɛσ- Werte, je mehr Nitrogruppen er im Molekül enthält. 3. Die voranstehende Gesetzmäßigkeit wurde an Hand quantitativer Löslichkeitsbestimmungen der verschiedenen Zellulosederivate in homologen Essigestern bestätigt. 4. Das Lösungsgebiet der Nitrozellulose ist abhängig von ihrem Stickstoffgehalt. Je niedriger die Zellulose nitriert ist, um so mehr verschiebt sich das Lösungsgebiet nach Gebieten kleinererμ 2/ɛσ-Werte.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01496525
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  • 30
    Electronic Resource
    Electronic Resource
    Soluble CD23 levels and their correlation with erythrocyte sedimentation rate and with copy number of Epstein-Barr virus genome in rheumatoid arthritis patients (1997)
    Springer
    Clinical rheumatology 16 (1997), S. 635-636 
    Details
    ISSN: 1434-9949
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02247809
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