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  • 1
    Digitale Medien
    Digitale Medien
    Vaginal delivery after previous caesarean section: is X-ray pelvimetry necessary? (1993)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 100 (1993), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Objective To determine whether antepartum X-ray pelvimetry (XRP) reliably identified women suitable for a trial labour or repeat elective caesarean section after one previous section.Design A prospective controlled trial in which women were randomly allocated to either an antepartum XRP group who had XRP at 36 weeks gestation to determine mode of delivery, or a control group who had a trial labour without antepartum XRP. Following delivery, all controls had postpartum XRP.Setting Department of Obstetrics and Gynaecology, King Edward VIII Hospital, Durban, South Africa.Subjects Three hundred-six women with a history of one previous caesarean section.Main outcome measures Mode of delivery, birthweight and maternal and perinatal mortality and morbidity in the two groups.Results In the antepartum XRP group, 23 of 144 (16%) of women delivered vaginally compared with 60 of 144 (42%) controls (P〈0.0001). Of the 84 women with adequate antepartum XRP only 23 (27.7%) delivered vaginally. In the control group, 33 of 60 (55%) women who had vaginal deliveries had inadequate postpartum XRP and would have had a caesarean section if this information was known in the antepartum period; 62 of 84 (74%) caesarean sections in the control group had adequate postpartum XRP. Birthweight of the infants was similar in the two groups. There were no maternal or perinatal deaths. Maternal morbidity was similar in the two groups. Neonatal morbidity was minimal.Conclusion Antepartum XRP is not necessary prior to a trial labour in women with one previous caesarean section. It increases the caesarean section rate and is a poor predictor of the outcome of labour.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1993.tb15265.x
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  • 2
    Digitale Medien
    Digitale Medien
    Electroencephalogram and computerised cerebral tomography findings in eclampsia (1993)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 100 (1993), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Objective To define more clearly the neuropathophysiology of eclampsia.Design A prospective study relating to computerised cerebral tomography (CAT) scan and electroencephalogram (EEG) findings in eclampsia.Setting A large referral centre in a developing society.Subjects Thirty-two women with eclampsia.Main outcome measures Abnormalities in EEG and CAT scan findings.Results Approximately 45% of the women studied had CAT scan abnormalities, while 90% had EEG abnormalities. A burst suppression pattern on EEG examination was found in four women suggesting a temporary dissolution of cerebral function to the midbrain level as the cause of seizures.Conclusions EEGs are probably more sensitive than CAT scans in detecting the extent of the pathology in the brain in women with eclampsia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1993.tb15138.x
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  • 3
    Digitale Medien
    Digitale Medien
    Authors' reply (1993)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 100 (1993), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1993.tb15160.x
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  • 4
    Digitale Medien
    Digitale Medien
    A comparative study of the use of epoprostenol and dihydralazine in severe hypertension in pregnancy (1992)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 99 (1992), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Objective To compare the antihypertensive effects of epoprostenol sodium (pros-tacyclin) with that of dihydralazine in acute hypertensive crises of pregnancy.Design A prospective randomized study. A minimum of 20 patients per group was considered statistically acceptable (alpha = 0.05, power = 0.9).Setting A large urban tertiary hospital.Subjects Forty-seven pregnant patients with diastolic blood pressures of 〉100 mmmHg were studied.Intervention Lowering of high blood pressure with either dihydralazine (n= 25), the standard drug for this purpose, or epoprostenol (n= 22).Main outcome measure A significant drop in high blood pressure was regarded as a fall of 15 mmHg diastolic and 30 mmHg systolic blood pressure.Results There were no statistically significant differences in the antihypertensive effects between the two treatment groups. Epoprostenol infusion caused less tachycardia; the mean pulse rate changed from 81.77 beats/min, before treatment to 88.36 at stabilization, compared with a change from 80.96 beats/min to 102.68 in the group treated with dihydralazine (P= 0.0024).Conclusion The place of epoprostenol in pregnancy might be in patients with severe hypertension and tachycardia and in those requiring acute control of severe hypertension on the operating table before general anaesthesia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1992.tb13872.x
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  • 5
    Digitale Medien
    Digitale Medien
    The efficacy of phenytoin in relation to serum levels in severe pre-eclampsia and eclampsia (1992)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 99 (1992), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Objectives To investigate the efficacy of phenytoin in relation to total and free serum levels in patients with severe pre-eclampsia and eclampsia.Design Prospective descriptive study.Setting Labour Ward, King Edward VIII Hospital, Durban, South Africa. Tertiary referral centre serving an underprivileged community.Subjects Eleven patients admitted with a hypertensive crisis. Four patients had eclampsia and 7 had impending eclampsia.Main outcome measures Free and total phenytoin levels; efficacy of phenytoin as an anticonvulsant and side-effects of therapy.Results Although total phenytoin levels were within the therapeutic range, free phenytoin levels were abnormally high in all patients. Three patients (2 with eclampsia and 1 with imminent eclampsia) each had a seizure after phenytoin treatment had been initiated.Conclusion Neither total nor free phenytoin levels were good predictors of seizure control. It is postulated that the poor performance of phenytoin as an anticonvulsant in severe eclampsia may relate to inadequate distribution of the drug to the brain as a result of cerebral oedema and poor cerebral perfusion rather than paradoxical seizure activity associated with high free phenytoin levels.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1992.tb14434.x
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  • 6
    Digitale Medien
    Digitale Medien
    Active management of the unconscious eclamptic patient (1986)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 93 (1986), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary. Of the many complications which may develop after eclamptic seizures, prolonged unconsciousness is one of the most difficult for obstetricians to manage as the pathophysiology of this condition remains largely unknown. Computed axial tomography (CT scan) was performed on 20 unconscious eclamptic patients, and autopsy was obtained on an additional two patients. Changes compatable with cerebral oedema were demonstrated in 75% of patients; cerebral haemorrhage occurred in 9%. A programme of intensive neurological management aimed at optimizing cerebral perfusion and controlling intracranial pressure is outlined. We have reduced the mortality rate for unconscious eclamptic patients from 50% to 17% in our institution.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1986.tb07953.x
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  • 7
    Digitale Medien
    Digitale Medien
    T594M mutation of the epithelial sodium channel β-subunit gene in pre-eclampsia and eclampsia in Black South African women (2004)
    Oxford, UK and Malden, USA : Blackwell Science Ltd
    BJOG 111 (2004), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The possible role of the β-subunit of the epithelial sodium channel T594M polymorphism in hypertensive disorders of pregnancy has not been examined. This study compared Black South African women with pre-eclampsia (n= 204), early onset pre-eclampsia (n= 67), eclampsia (n= 120) and gestational hypertension (n= 78) with 338 women from the same ethnic group who had full-term normotensive pregnancies, for the presence of the T594M polymorphism. The variant allele was detected in 1.7% to 3.8% of the various patient groups and in 3.6% of the control group reflecting no significant difference. These results suggest that the T594M polymorphism in the sodium channel β-subunit is not associated with the pathogenesis of pre-eclampsia or gestational hypertension.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.2004.00221.x
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  • 8
    Digitale Medien
    Digitale Medien
    Absence of Factor V Leiden, thrombomodulin and prothrombin gene variants in Black South African women with pre-eclampsia and eclampsia (2003)
    Oxford, UK : Blackwell Science Ltd
    BJOG 110 (2003), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: It has been suggested that gene aberrations may contribute to vascular endothelial dysfunction of pre-eclampsia in Caucasian and Japanese women. This study was undertaken to examine the association between pre-eclampsia in Black Zulu speaking South African women and the Factor 5 Leiden mutation. 100 patients with pre-eclampsia comprised the study group. The control group comprised 110 normotensive pregnant women of the same population group. Genotyping was performed to detect the G or A allele at residue 506 of the Factor V gene, and the C or T allele at residue 455 of the thrombomodulin gene. Our findings demonstrate that these particularly genetic loci are of little use in disease association studies for pre-eclampsia in homogenous Zulu speaking Africans.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1471-0528.2003.01090.x
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  • 9
    Digitale Medien
    Digitale Medien
    Vulval cytomegalovirus coexisting with herpes simplex virus in a patient with human immunodeficiency virus infection (2003)
    Oxford, UK : Blackwell Science Ltd
    BJOG 110 (2003), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.2003.02083.x
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  • 10
    Digitale Medien
    Digitale Medien
    Author's Reply (2002)
    Oxford, UK : Blackwell Science Ltd
    BJOG 109 (2002), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1471-0528.2002.1022b.x
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