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  • 1
    Buch
    Buch
    Advances in sensitivity analysis and parametric programming (1997)
    Boston u.a. :Kluwer,
    Details
    Titel: Advances in sensitivity analysis and parametric programming
    Beteiligte Person(en): Gal, Tomas , Greenberg, Harvey J.
    Verlag: Boston u.a. :Kluwer,
    Erscheinungsjahr: 1997
    Serie: International series in operations research and management science
    Materialart: Buch
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  • 2
    Digitale Medien
    Digitale Medien
    Time-Related Loss of Glutamine from Hippocampal Slices and Concomitant Changes in Neurotransmitter Amino Acids (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 61 (1993), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: A dramatic, time-dependent loss of l-glutamine was observed in mouse and rat hippocampal slices equilibrated in normal artificial CSF under static (no-flow) and super-fused (constant-flow) conditions. Concomitant with the decline in l-glutamine, there was a significant, but less pronounced, decrease in levels of the neurotransmitter amino acids, γ-aminobutyric acid, l-aspartate, and l-glutamate. The disappearance of l-glutamine was a result of diffusion from the tissue to the artificial CSF rather than chemical or biochemical transformation. The loss of amino acids from the hippocampal slices was prevented to different degrees by the addition of 0.5 mM exogenous l-glutamine to the artificial CSF. The levels of newly synthesized amino acids were also determined, because they may be more indicative of the neuronal activity than the total tissue levels of amino acids. The effects of perturbations in glutamine (length of the equilibration time and addition of exogenous. glutamine) on newly synthesized glutamate were more pronounced under 4-aminopyridine-stimulated than control (unstimulated) conditions. Therefore, a loss of l-glutamine from the hippocampal slices may have neurophysiological effects and warrants further investigation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1993.tb03597.x
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  • 3
    Digitale Medien
    Digitale Medien
    Activation of Protein Kinase C by the Capsaicin Analogue Resiniferatoxin in Sensory Neurones (1995)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 65 (1995), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Resiniferatoxin and capsaicin are sensory neurone-specific excitotoxins that operate a common cation channel in nociceptors. Resiniferatoxin is structurally similar to capsaicin and to phorbol esters. Specific [3H]-resiniferatoxin binding, which was detected in the membrane (KD value 1.8 ± 0.2 nM) but not cytosolic fraction of rat dorsal root ganglia, could not be displaced by phorbol 12,13-dibutyrate. Conversely, resiniferatoxin did not displace [3H]phorbol 12,13-dibutyrate binding in either the cytosolic or membrane fraction. Resiniferatoxin and capsaicin both caused translocation of protein kinase C in dorsal root ganglion neurones (EC50 value 18 ± 3 nM). This translocation was greatly reduced but not abolished, in the absence of external Ca2+, suggesting that it was secondary to Ca2+ entry. Resiniferatoxin also caused direct activation of a Ca2+- and lipid-dependent kinase (or kinases) in the cytosolic fraction of dorsal root ganglia, at concentrations (100 nM to 10 µM) higher than required for displacement of [3H]resiniferatoxin binding or translocation of protein kinase C. Capsaicin (up to 10 µM) was unable to mimic this effect. These data imply that although resiniferatoxin-induced translocation of protein kinase C in dorsal root ganglion neurones was mainly indirect, it also caused direct activation of a protein kinase C-like kinase in these cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1471-4159.1995.65031309.x
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  • 4
    Digitale Medien
    Digitale Medien
    Immunohistochemical Localization of Intermediate Filament Proteins of Neuronal and Nonneuronal Origin in the Goldfish Optic Nerve: Specific Molecular Markers for Optic Nerve Structures (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 47 (1986), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract The predominant proteins (58K) of the intermediate filament complex in the goldfish visual pathway consist of a series of isoelectric variants. Previous biochemical studies have shown that proteins ON1 and ON2 are of neuronal origin, whereas ON3 and ON4 are of nonneuronal origin. Polyclonal antibodies, purified by affinity chromatography, that are specific for ON1 and ON2 or ON3 and ON4 have been used to localize histologically the ON proteins within the normal and crushed optic nerve. Anti-ON1/ON2 antiserum presented a pattern consistent with intraaxonal staining. A nonneuronal staining pattern was observed with anti-ON3/ON4 antiserum. The two patterns were distinct from and complementary to each other. The data suggest that ON3 and ON4 represent a novel glial fibrillary acidic protein. The results are discussed in terms of the function of these proteins in development, plasticity, and regeneration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1986.tb00744.x
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  • 5
    Digitale Medien
    Digitale Medien
    Presence and Ontogeny of Enkephalin and Substance P in the Chick Ciliary Ganglion (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 45 (1985), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: The avian ciliary ganglion has been reported to contain both enkephalin and substance P in preganglionic terminals. However, extensive biochemical characterization of these antigens has not been completed. Using radioimmunoassays specific for Met5-and for Leu5-enkephalin and for substance P we identified immunoreactive substances in ganglionic extracts that comigrate on HPLC columns with standard Met5- and Leu5-enkephalin and with substance P. The ontogeny of Met5-enkephalin and substance P during embryogenesis was determined in ganglionic extracts and we found that the content of Met5-enkephalin in the ganglion reached a peak at embryonic stage 37 whereas the content of substance P in the ganglion reached its maximum in the adult.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1985.tb05562.x
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  • 6
    Digitale Medien
    Digitale Medien
    Metabolism of dimethoxymethylphenobarbital in mice. Relation between brain phenobarbital levels and anticonvulsant activity (1973)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 16 (1973), S. 599-602 
    Details
    ISSN: 1520-4804
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/jm00264a004
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  • 7
    Digitale Medien
    Digitale Medien
    Stereotypes and Moral Oversight in Conflict Resolution: What Are We Teaching? (2002)
    Oxford, UK and Boston, USA : Blackwell Publishers Ltd.
    Journal of philosophy of education 36 (2002), S. 0 
    Details
    ISSN: 1467-9752
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Pädagogik , Philosophie
    Notizen: I examine some common trends in ‘conflict management skills’, particularly those focused on practical results, and argue that they involve some moral problems, like the reliance on offensive stereotypes, the censorship of moral language, the promotion of distorted relationships, and sometimes the suppression of basic rights and obligations that constitute non–consequentialist moral constraints on human interactions (including dispute resolution). Since these approaches now appear in educational institutions, they are sending dangerous messages to those least able to critically assess them, messages that denigrate the language, reflection, and interactions on which the moral life depends, thus undermining the possibility of moral education in the most fundamental sense of the phrase.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/1467-9752.00292
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  • 8
    Digitale Medien
    Digitale Medien
    PRICING POLICY REACTIONS TO AGGLOMERATION IN A MARKET WITH SPATIAL SEARCH (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of regional science 36 (1996), S. 0 
    Details
    ISSN: 1467-9787
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Geographie , Wirtschaftswissenschaften
    Notizen: . Price dispersion (variation) and agglomeration are common characteristics of spatial markets, in particular, markets with imperfect consumer information and search. However, pricing and location strategies in these markets are not well analyzed since spatial search is difficult to model without restricting the spatial dimension of the problem. This paper analyzes pricing and location strategies in a market with spatid search using a probabilistic modeling strategy that does not restrict search patterns in the plane. Specifically, the analysis considers the pricing strategy of an isolated firm in response to the agglomeration of competing firms. Results indicate that spatial and temporal price dispersion are effective responses to competitors'agglomeration. However, the relative effectiveness of these strategies varies with market conditions. In addition, agglomeration can have some counterintuitive effects. This paper also provides insights into existing theories of spatial search and spatial competition in spatially-restricted (linear and circular) markets.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1467-9787.1996.tb01109.x
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  • 9
    Digitale Medien
    Digitale Medien
    Competing internationally through multiple innovative efforts (1993)
    Oxford, UK : Blackwell Publishing Ltd
    R & D management 23 (1993), S. 0 
    Details
    ISSN: 1467-9310
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Wirtschaftswissenschaften
    Notizen: Increasingly, small firms will be required to compete on international markets in order to grow and survive. This paper reports on a study of 86 small manufacturing firms operating in the metal sector. All firms had adopted one or more advanced manufacturing technology and were considered by the Canadian Association of Manufacturers as process innovative. The basic premise of this research was that in order to compete internationally, a small firm had to develop certain innovative capabilities. These capabilities were not only associated to traditional innovative efforts in R&D and process innovation, but also in supportive organizational capabilities in the form of strategic orientation, technological policy, and technological scanning. Results show that, for these small firms, process innovativeness remains an important competitive factor for international competition and that it is often linked to an aggressive strategic orientation coupled to a short term emphasis on efficiency.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1467-9310.1993.tb00825.x
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  • 10
    Digitale Medien
    Digitale Medien
    Reversible sulfhydryl-catalyzed structural alteration of bovine mercaptalbumin (1971)
    s.l. : American Chemical Society
    Biochemistry 10 (1971), S. 4479-4486 
    Details
    ISSN: 1520-4995
    Quelle: ACS Legacy Archives
    Thema: Biologie , Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/bi00800a020
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