ISSN:
1434-4475
Schlagwort(e):
Maleimides
;
Chemoimmunoconjugates
;
Crosslinking reagent
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
Notizen:
Summary Bifunctional maleimide compounds are suitable for binding small molecules to carrier proteins in that they bind to the sulfhydryl group of proteins through the double bond of the maleimide group and to molecules of low molecular weight (e.g. anticancer drugs) through a functional groupX. 18 maleimide compounds of the general formula Maleimid-R-X (R=phenylene, benzyl-, methylene-, ethylene, or am-benzoylethylamide group andX=hydroxy-, amino-, hydrazino-, carboxylic acid-, carboxylic anhydride-, carboxylic acid chloride-, carboxylic acid hydrazide-, oxycarbonylchloride-, aldehyde, keto-, orp-toluenesulfonate-group) were synthesized and characterized through1H- and13C-NMR-spectroscopy, elemental analysis, and mass spectrometry.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00807643
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