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1

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Combined Administration of a 5-Hydroxytryptamine (5-HT)1D Antagonist and a 5-HT Reuptake Inhibitor Synergistically Increases 5-HT Release in Guinea Pig Hypothalamus In Vivo (1996)

Rollema, Hans ; Clarke, Thomas ; Sprouse, Jeffrey S. ; [et al.]

Oxford, UK : Blackwell Science Ltd

Journal of neurochemistry 67 (1996), S. 0

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ISSN: 1471-4159

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Abstract: In vivo microdialysis in guinea pig hypothalamus was used to study the effect of serotonin [5-hydroxytryptamine (5-HT)] subtype 1D autoreceptor blockade on the increase in extracellular 5-HT levels produced by a selective 5-HT reuptake inhibitor (SSRI). Administration of the selective 5-HT1D antagonist GR127935 at 0.3 mg/kg had no effect, but 5 mg/kg significantly increased extracellular levels of 5-HT and 5-hydroxyindoleacetic acid to 135% of basal values. Moreover, at these doses GR127935 significantly attenuated the decrease in extracellular 5-HT levels following local perfusion with the selective 5-HT1D agonist CP-135,807. The SSRI sertraline at 2 mg/kg increased 5-HT levels to 130% of basal levels. The combination of this low dose of sertraline with either dose of GR127935 resulted in a pronounced, long-lasting increase in 5-HT levels to 230% of basal values. These results indicate that the effects of an SSRI on terminal 5-HT are significantly enhanced by coadministration of a 5-HT1D antagonist and confirm that in addition to somatodendritic 5-HT1A autoreceptors, terminal 5-HT1D autoreceptors mitigate the effect of SSRIs on terminal 5-HT. As such, antagonists of the 5-HT1D autoreceptor could be useful as rapidly acting antidepressants and may shorten the onset of antidepressant action when combined with SSRIs.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1046/j.1471-4159.1996.67052204.x

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2

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Efficient and convenient synthesis of 1-methylcyclopropene (1971)

Magid, Ronald M. ; Clarke, Thomas C. ; Duncan, Charles D.

s.l. : American Chemical Society

The @journal of organic chemistry 36 (1971), S. 1320-1321

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ISSN: 1520-6904

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1021/jo00808a041

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3

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In Defence Of Mutuality (1998)

Clarke, Thomas

Oxford, UK and Boston, USA : Blackwell Publishers Ltd

Business ethics 7 (1998), S. 0

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ISSN: 1467-8608

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Philosophy , Economics

Notes: “There was something a little unseemly about how the building societies intending to demutualise did so by encouraging their members to vote in favour with the inducement of significant payments in shares”. Should one have no regard for the intentions of those who produced the present capital accumulation, or for the idea of holding reserves in trust for future members? The author is DBM Professor of Corporate Governance at Leeds Business School, Leeds Metropolitan University, Calverley Street, Leeds LS1 3HE.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/1467-8608.00094

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4

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Editorial Navigating the Knowledge Economy (2001)

Clarke, Thomas

Oxford, UK and Boston, USA : Blackwell Publishers Ltd

Creativity and innovation management 10 (2001), S. 0

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ISSN: 1467-8691

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Economics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/1467-8691.00216

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5

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Introduction: Pacific Paradigms (1999)

Clarke, Thomas

Oxford, UK and Boston, USA : Blackwell Publishers Ltd

Creativity and innovation management 8 (1999), S. 0

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ISSN: 1467-8691

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Economics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/1467-8691.00113

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6

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Inversion component in the solvolytic displacement reactions of alkyl-substituted vinyl trifluoromethanesulfonates (1972)

Clarke, Thomas C. ; Kelsey, Donald R. ; Bergman, Robert G.

s.l. : American Chemical Society

Journal of the American Chemical Society 94 (1972), S. 3626-3627

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ISSN: 1520-5126

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1021/ja00765a061

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Olefinic cyclization at a vinyl cation center. Inversion preference for intramolecular nucleophilic substitution by a double bond (1972)

Clarke, Thomas C. ; Bergman, Robert G.

s.l. : American Chemical Society

Journal of the American Chemical Society 94 (1972), S. 3627-3629

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ISSN: 1520-5126

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1021/ja00765a062

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8

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ON β-HEPTYLAMINE.1,2 (1899)

Clarke, Thomas

s.l. : American Chemical Society

Journal of the American Chemical Society 21 (1899), S. 1027-1031

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ISSN: 1520-5126

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1021/ja02061a009

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9

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Review Essay: Mapping out the Field (1994)

Clarke, Thomas

Oxford, UK : Blackwell Publishing Ltd

Corporate governance 2 (1994), S. 0

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ISSN: 1467-8683

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Political Science , Economics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1467-8683.1994.tb00083.x

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10

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Haemorrhaging Tigers: the power of international financial markets and the weaknesses of Asian modes of corporate governance (2000)

Clarke, Thomas

Oxford, UK and Boston, USA : Blackwell Publishers Ltd

Corporate governance 8 (2000), S. 0

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ISSN: 1467-8683

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Political Science , Economics

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/1467-8683.00188

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