Digitale Medien
Springer
Virchows Archiv
421 (1992), S. 189-192
ISSN:
1432-2307
Schlagwort(e):
Malnutrition
;
Ageing
;
Myocardium
;
Microvasculature
;
Morphometry
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Summary The modulating effects of ageing and malnutrition on rat myocardium were studied morphometrically with respect to the microvasculature. An increase in capillary density together with a decrease in capillary lumen cross-sectional area was noted during starvation. The important changes seen in the myocyte T-system were paralleled by a decreased diffusion distance for oxygen from the capillary lumen to the mitochondrion. The changes described in the aged rat heart point to an altered inter-relationship between parenchyma and vascularization with a lower capillary volume fraction and a greater diffusion distance from the capillary lumen to the mitochondrion; this is caused by hypertrophy of the aged myocyte. This reduction in capacity to exchange substrates is further reduced by the less developed T-system in the older myocyte.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF01611174
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