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Digitale Medien

Factors affecting the synthesis of penicillins by the immobilized penicillin acylase from Escherichia coli (1994)

Koteva, K. P. ; Ganchev, K. D.

Berlin : Wiley-Blackwell

Acta Biotechnologica 14 (1994), S. 37-43

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Details

ISSN: 0138-4988

Schlagwort(e): Life Sciences ; Life Sciences (general)

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: The effect of pH, temperature, reactant concentration, and reaction time has been investigated for the synthesis of N-benzhydryl-N′-acetamidopiperazyl-6-penicillanic acid and N-benzyl-N′-acetamidopiperazyl-6-penicillanic acid from 6-aminopenicillanic acid by the immobilized penicillin acylase from Escherichia coli. The synthesis of penicillins from carboxylic acids proceeds most rapidly at pH 5; with ethyl ester derivatives of carboxylic acids the pH optimum is higher (6-7). The most rapid synthesis of penicillins was obtained with ethyl ester derivatives of carboxylic acids. The optimum temperatures were 25-35°C.

Zusätzliches Material: 9 Tab.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/abio.370140105

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