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  • 2000-2004  (4)
  • 1965-1969  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Voltage- and Ca2+-Dependent Burst Generation in Neuroendocrine Dahlgren Cells in the Teleost Platichthys flesus (2004)
    Oxford, UK : Blackwell Science Ltd
    Journal of neuroendocrinology 16 (2004), S. 0 
    Details
    ISSN: 1365-2826
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The neuroendocrine Type 1 Dahlgren cells of the caudal neurosecretory system of the flounder display characteristic bursting activity, which may increase secretion efficiency. The firing activity pattern in these cells was voltage-dependent; when progressively depolarized, cells moved from silent (approximately −70 mV), through bursting and phasic to tonic firing (〈 −65 mV). Brief (10 s) evoked bursts of spikes were followed by a slow after-depolarization (ADP; amplitude up to 10 mV, duration 10–200 s), which was also voltage-dependent and could trigger a prolonged burst. The ADP was significantly reduced in the absence of external Ca2+ ions or the presence of the L-type Ca2+ channel blocker, nifedipine. BayK 8644 (which increases L-type channel open times) significantly increased ADP duration, whereas the Ca2+-activated nonselective cation channel blocker, flufenamic acid, had no effect. Pharmacological blockade of Ca2+-activated K+ channels, using apamin and charybdotoxin, increased the duration of both ADP and evoked bursts. However, action potential waveform was unaffected by either apamin/charybdotoxin, nifedipine, BayK 8644 or removal of external Ca2+. The short duration (approximately 100 ms), hyperpolarization-activated, postspike depolarizing afterpotentials (DAP), were significantly reduced by nifedipine. We propose that long duration ADPs underlie bursts and that short duration DAPs play a role in modulation of spike frequency.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2826.2004.01238.x
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  • 2
    Digitale Medien
    Digitale Medien
    A prospective, randomized, double-blind, placebo-controlled multi-centre study on the efficacy and safety of sublingual immunotherapy (SLIT) in children with seasonal allergic rhinoconjunctivitis to grass pollen (2004)
    Oxford, UK : Munksgaard International Publishers
    Allergy 59 (2004), S. 0 
    Details
    ISSN: 1398-9995
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background:  Especially in childhood, sublingual immunotherapy (SLIT) could offer advantages over subcutaneous therapy. However, limited data on its efficacy is available.Methods:  In four German centres 97 children (age 3–14 years) with allergic rhinoconjunctivitis to grass pollen were enrolled in a prospective, double-blind trial comparing SLIT (Pangramin SLIT®; ALK-SCHERAX, 0.5 μg major allergens, three times per week, 32 months) with placebo. Primary endpoint was a multiple symptom-medication score for changes in seasonal diary entries between the first and third year of the study (SLIT n = 39; placebo n = 38).Results:  The multiple symptom-medication score was significantly reduced by SLIT to 77.3% of the placebo group (P = 0.0498). The subsequent analysis of the single endpoints did not reveal significant differences for symptom scores in favour of SLIT (85.1% of placebo group; P = 0.22). However, the medication score improved significantly (67.1% of placebo group; P = 0.0025). Furthermore, secondary endpoints assessing in vivo immune responses did not differ significantly between the groups. However, retrospective analysis showed some inhomogeneity for clinical and in vitro parameters at the beginning of the study. Allergic side effects with possible relation to the study drug were reported in both groups (SLIT 49%, placebo 27%, P = 0.026).Conclusion:  Our study indicates that SLIT had a positive effect on the reduction of a multiple symptom-medication score, mainly by significantly reducing rescue medication use, but had no significant effect on symptoms alone in children with rhinoconjunctivitis to grass pollen compared with a placebo.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1398-9995.2004.00627.x
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  • 3
    Digitale Medien
    Digitale Medien
    Kinetic parameters of dehydrogenase in the assessment of the response of soil to vermicompost and inorganic fertilisers (2000)
    Springer
    Biology and fertility of soils 32 (2000), S. 479-483 
    Details
    ISSN: 1432-0789
    Schlagwort(e): Keywords Vermicompost ; Mineral fertiliser ; Dehydrogenase kinetics ; Soil fertility
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Geologie und Paläontologie , Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Abstract  Kinetic parameters (V max and K m) of dehydrogenase activity were determined in order to assess the metabolic response of a soil about 1 year after organic and mineral treatments. The soil was planted with maize (Zea mays) and treated with the following fertilisers: organic (vermicompost; VC), mineral (ammonium phosphate and urea), and an organo-mineral mixture. V max, which represents a measurement of the quantity of enzyme, markedly increased in organic and organo-mineral treatments, indicating that the addition of organic matter caused an increase in dehydrogenase in the active microbial biomass. K m, representing enzyme-substrate affinity and/or different sources of the enzymes, was similar in VC-treated soil and control soil, while it doubled in organo-mineral and mineral treatments. These results suggest that the use of VC did not alter the enzyme-substrate affinity, while mineral fertiliser reduced this affinity or changed the composition and activity of soil microbiota. A positive correlation was found between V max, the metabolic index (dehydrogenase/water-soluble carbon ratio), and the soil organic matter content. The kinetic constants of dehydrogenase activity and the metabolic index may be considered valid parameters to monitor the evolution of microbiological activity in soil.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s003740000280
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  • 4
    Digitale Medien
    Digitale Medien
    Operator representations on quantum spaces (2003)
    Springer
    The European physical journal 31 (2003), S. 261-275 
    Details
    ISSN: 1434-6052
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract. In this article we present explicit formulae for q-differentiation on quantum spaces which could be of particular importance in physics, i.e., q-deformed Minkowski space and q-deformed Euclidean space in three or four dimensions. The calculations are based on the covariant differential calculus of these quantum spaces. Furthermore, our formulae can be regarded as a generalization of Jackson’s q-derivative to three and four dimensions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1140/epjc/s2003-01324-0
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  • 5
    Digitale Medien
    Digitale Medien
    Korrosionsgeschützte Verbindungselemente. Neue Entwicklungen - Erste NormenVortrag im Rahmen „Werkstoff- und Korrosions-Probleme bei neuen oder modifizierten chemischen Verfahren“  -  Achema 1967. (1968)
    Weinheim [u.a.] : Wiley-Blackwell
    Materials and Corrosion/Werkstoffe und Korrosion 19 (1968), S. 193-200 
    Details
    ISSN: 0947-5117
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Beschreibung / Inhaltsverzeichnis: Corrosion-protected connecting devices. Recent developments. First StandardsWith connecting devices, manufacture and materials should be attuned to each other in order to attain optimum results. Through cold forming, higher yield limits can be reached which prevail even at temperatures up to 400° C and entail considerable savings in size.According to German Standards DIN 267, Sheet 11, the conventional specifications for the material alone are superseded by quality specifications. While meeting the minimum requirements to be guaranteed, the manufacturer is free to choose, from among the steels of the specified group, those steels which in conjunction with the manufacturing process produce the best results.Testing and acceptance conditions should be adapted to the application conditions. Previously standardized, conventional testing methods should be modified. The tensile test should be carried out on entire bolts; nuts subjected to the load test should be exposed to the rupture load corresponding to the quality of the bolts to which they are to be fitted. Practical experience and the results of calibration tests do not suggest that the corrosion strength of the connecting devices would be impaired by cold forming under such conditions. Appearance and corrosion resistance can be improved by electro-polishing. With nitrogen-alloyed austenitic chrome-nickel steels, the mechanical strength characteristics can be improved still further while the torrosion resistance remains at least as good.
    Notizen: Fertigungsverfahren und Werkstoffe müssen bei Verbindungselementen wechselseitig aufeinander abgestimmt werden, um optimale Werte zu erreichen. Durch Kaltumformen werden höhere Streckgrenzenwerte erreicht, die auch bei Temperaturen bis 400° C erhalten bleiben und zu erheblichen Ersparnissen in der Dimensionierung führen.An die Stelle einer reinen Werkstoffvorschrift tritt nach DIN 267 Blatt 11 die Gütergruppe. Unter Beachtung zu gewährleistender Mindestwerte kann der Hersteller für die Fertigung wechselseitig aus der gleichen Stahlgruppe die am besten geeigneten Stähle auswählen.Prüf- und Abnahmebedingungen sind den Verhältnissen des Einsatzes anzupassen. Bisher genormte und übliche Prüfanordnungen müssen geändert werden. Der Zugversuch ist an ganzen Schrauben durchzuführen, Muttern sind im Prüflastversuch bis zur Bruchlast der mit ihr zu verschraubenden Schraubengüter zu belasten. Praktische Erfahrungen und Kontrollversuche ergaben keine Beeinträchtigung der Korrosionsbeständigkeit durch das Kaltformen für Verbindungselemente unter diesen unter diesen Bedingungen. Aussehen und Korrosionsbeständigkeit lassen durch Elektropolieren steigern. Mit stickstofflegierten austenitischen Chrom-Nickel-Stählen ist eine weitere Erhöhung der Festigkeiten bei mindestens gleicher Korrosionsbeständigkeit möglich.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/maco.19680190302
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