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Digitale Medien

Inhibitory effect of lysophosphatidylcholine on the histamine release from rat peritoneal mast cells (1985)

Mio, M. ; Ikeda, A. ; Akagi, M. ; [weitere]

Springer

Inflammation research 16 (1985), S. 113-117

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Details

ISSN: 1420-908X

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Histamine release from isolated rat peritoneal mast cells induced by compound 48/80 (0.5 μg/ml) or antigen-antibody reaction was inhibited by lysophosphatidylcholine in a dose-dependent fashion at concentrations up to 4 μM. Within the same range of concentration, lysophosphatidylcholine exhibited a membrane-stabilizing action on the model membrane systems decreasing the permeability of lipid bilayer and the fluidity of liposomal membrane in the liquid crystalline state. At concentrations higher than 8 μM, lysophosphatidylcholine damaged the cell membrane and subsequently histamine was released. It was assumed that lysophosphatidylcholine may act as an endogenous membrane stabilizer inhibiting histamine release in normal mast cells.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01983115

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