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  • 1
    Electronic Resource
    Electronic Resource
    Crystallization of the receptor binding domain of vascular endothelial growth factor (1996)
    New York, NY : Wiley-Blackwell
    Proteins: Structure, Function, and Genetics 26 (1996), S. 353-357 
    Details
    ISSN: 0887-3585
    Keywords: VEGF ; angiogenesis ; tumor vascularization ; inclusion bodies ; cysteine mutants ; X-ray crystallography ; crystals ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Vascular endothelial growth factor (VEGF) is a potent angiogenic factor with a unique specificity for vascular endothelial cells. In addition to its role in vasculogenesis and embryonic angiogenesis, VEGF is implicated in pathologic neovascularization associated with tumors and diabetic retinopathy. Four different constructs of a short variant of VEGF sufficient for receptor binding were overexpressed in Escherichia coli, refolded, purified, and crystallized in five different space groups. In order to facilitate the product on of heavy atom derivatives, single cysteine mutants were designed based on the crystal structure of platelet-derived growth factor. A construct consisting of residues 8 to 109 was crystallized in space group P21, with cell parameters a = 55.6 Å, b = 60.4 Å, c = 77.7 Å, β = 90.0°, and four monomers in the asymmetric unit. Native and derivative data were collected for two of the cysteine mutants as well as for wild-type VEGF. © 1996 Wiley-Liss, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 2
    Electronic Resource
    Electronic Resource
    Das elektromotorische Verhalten des Magnesiums, sowie der Magnesiumamalgame (1923)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 130 (1923), S. 173-180 
    Details
    ISSN: 0863-1786
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19231300117
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  • 3
    Electronic Resource
    Electronic Resource
    Stereoselective binding of etodolac to human serum albuminPresented at the Second International Symposium on Chiral Discrimination, May 27-31, 1991, Rome, Italy. (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 4 (1992), S. 240-246 
    Details
    ISSN: 0899-0042
    Keywords: NSAID ; chirality ; enantiomers ; protein binding ; equilibrium dialysis ; fluorescent specific markers ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The protein binding of etodolac enantiomers was studied in vitro by equilibrium dialysis in human serum albumin (HSA) of various concentrations varying from 1 to 40 g/liter, by addition of each enantiomer at increasing concentrations. In the 1 g/liter solution, at the lowest drug levels, the (R)-form is more bound than its antipode, the contrary being observed at the highest drug levels. For higher albumin concentrations, S was bound in a larger extent than R. Using the displacement of specific markers of HSA sites I and II, studied by spectrofluorimetry, it was suggested that R and S are both bound to site I, while only S is strongly bound to site II. © 1992 Wiley-Liss, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chir.530040407
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  • 4
    Electronic Resource
    Electronic Resource
    Influence of dust particles on the hydrodynamic behavior and mass transfer in droplet column (1997)
    Weinheim : Wiley-Blackwell
    Chemical Engineering & Technology - CET 20 (1997), S. 469-474 
    Details
    ISSN: 0930-7516
    Keywords: Chemistry ; Industrial Chemistry and Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Bubble columns are commonly used in industry for polluted gas treatment. Based on the same principle, the droplet column which is not widely known in the literature, uses much higher gas velocities, up to 14 m/s. This study concerns the hydrodynamics and mass transfer in this apparatus, in presence or absence of solid particles. Our results have demonstrated the impact of dusts on mass transfer performance giving rise to an increase in the kL aL coefficient with decreasing particle size. However, no influence of dust on the hydrodynamics of the column has been demonstrated within the studied particle size range.A study of liquid holdups obtained by three different methods is also carried out. Our results are comparable, thus validating the methods used.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ceat.270200706
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  • 5
    Electronic Resource
    Electronic Resource
    Electrospray mass spectrometry on a magnetic sector instrument applied to heteropolyacids (1994)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 8 (1994), S. 692-694 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Electrospray mass spectrometry has been applied to ionic inorganic systems such as heteropolyacids in methanol + water (1/1) or acetonitrile + water (1/1) solutions. Negative-ion mass spectra were obtained on four different heteropolyacids. Heteropolymolybdates H3PMo12O40 and H4PMo11VO40 and heteropolytungstates H3PW12O40 and H4SiW12O40 gave ions with different charges. H3PMo12O40 gave ions of m/z 1822, 912 and 608 which correspond respectively to [PMo12O403- + 2H+], [PMo12O403- + H+]2- and [PMo12O40]3- ions. Resolution of 1:2200 has demonstrated the charge of each ion acquired. Furthermore, the isotope distribution of the observed ions was in good agreement with theory. Thus, electrospray mass spectrometry has become a powerful soft ionization technique for the analysis of such ionic compounds, provided they are soluble and stable in the solvent system used.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290080905
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  • 6
    Electronic Resource
    Electronic Resource
    A new method for the determination of iron oxidation states by resonant and non-resonant ionization mass spectrometry (1995)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 9 (1995), S. 225-229 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Different compositions of micrometric particles of powdered iron oxides (Fe1-xO, Fe3O4 and Fe2O3) are examined by time-of-flight laser microprobe mass spectrometry. The positive-ion cluster distributions show a strong correlation with the stoichiometry of iron in the oxide. This correlation is more striking when the resonant process of iron at 293.7 nm is used. The bond dissociation energy of Fe--O in the bulk Fe1-xO also affects the intensity distributions. It is very important to study and to identify the iron oxides because they could play a role in the toxicity of certain molecules which could be removed on the oxides.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290090310
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  • 7
    Electronic Resource
    Electronic Resource
    Mechanistic study of thermal behavior and combustion performance of epoxy resins: I homopolymerized TGDDM (1995)
    New York, NY : Wiley-Blackwell
    Polymers for Advanced Technologies 6 (1995), S. 53-62 
    Details
    ISSN: 1042-7147
    Keywords: epoxy resin ; homopolymerization ; thermal decomposition ; combustion ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Tetraglycidyl 4,4′-diaminodiphenylmethane (TGDDM) undergoes homopolymerization on heating. Intramolecular reactions which compete with crosslinking favor the formation of cyclic structures with increasing thermal and fire resistance of the resin, whereas physical mechanical properties tend to decrease.The mechanism of thermal decomposition of TGDDM is studied by thermogravimetry, differential scanning calorimetry and thermal volatilization analysis with characterization of volatiles evolved and residue left. Thermal degradation of poly-(TGDDM) starts at 260°C with elimination of water from secondary alcoholic groups which is a typical pathway for epoxy resin degradation. Resulting unsaturations weaken bonds in the β-position and provoke the first chain breaking at allyl-amine and allyl-either bonds. With increasing temperature, saturated alkyl-ether bonds and alkyl carbon-carbon bonds are broken first, followed by the most stable alkyl-aryl bonds at T〉365°C. The combustion performance of TGDDM is discussed on the basis of the thermal degradation behavior.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pat.1995.220060201
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  • 8
    Electronic Resource
    Electronic Resource
    Epoxy resins cured with aminophenylmethylphosphine oxide 1: Combustion performance (1996)
    New York, NY : Wiley-Blackwell
    Polymers for Advanced Technologies 7 (1996), S. 823-830 
    Details
    ISSN: 1042-7147
    Keywords: epoxy resin ; phosphorylated hardener ; combusion ; fire retardancy ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The kinetics of curing tetraglycidyl 4,4′-diaminodiphenyl methane (TGDDM) or of the mixture TGDDM/diglycidylether of bisphenol A (DGEBA) by bis(m-aminophenyl)methylphosphine oxide (BAMPO) was studied using differential scanning calorimetry. At low advancement of curing (〈50%), the low activation energy interaction between epoxy and amino groups seems to be controlled by diffusion, whereas above 50% the role of homopolymerization tends to increase and the process becomes chemically controlled.BAMPO shows a higher fire-retardant effectiveness in the mixture TGDDM/DGEBA than in TGDDM or DGEBA alone, for which the oxygen and nitrous oxide index tests suggest a condensed phase or a gas phase fire-retardant action depending on phosphorus content. An intumescent char is formed on the surface of burning fire-retarded specimens which tends, however, to be oxidized, thus reducing the fire-proofing effect at high BAMPO content.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 9
    Electronic Resource
    Electronic Resource
    Laser-desorption Fourier-transform mass spectrometry of triazines adsorbed on solid-phase extraction membranesContribution from the 2nd European FTMS Workshop, Antwerp, Belgium, September 1993. (1994)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 8 (1994), S. 22-25 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Until the present, analysis of aqueous solutions of atrazine has been conducted using a combination of liquid chromatography or gas chromatography with mass spectrometry, after a preconcentration step. We explore herein a new approach for studying support-phase-extracted atrazine and hydroxyatrazine samples. Solid-phase extraction membranes are inserted directly into the cell of a Fourier-transform mass spectrometer for analysis after laser ionization. It appears that atrazine and its metabolite have very different ionization processes. In the case of hydroxyatrazine, the [M + H]+ ion signal can be correlated to the concentration of the extracted solution. These encouraging results might open the route to a quantification method.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290080105
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  • 10
    Electronic Resource
    Electronic Resource
    Hydrophobic vs coulombic interactions in the binding of steroidal polyamines to DNA (1996)
    Chicester [u.a.] : Wiley-Blackwell
    Journal of Molecular Recognition 9 (1996), S. 143-148 
    Details
    ISSN: 0952-3499
    Keywords: polyamines ; steroids ; DNA ; DNA binding ; hydrophobic effects ; Coulombic interactions ; guanidinium ion ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Seven new steroidal polyamines derived from bile acids, either lithocholic or deoxycholic acid, have been studied as DNA-binding agents using four complimentary methods: an ethidium displacement assay, observed changes in the thermal denaturation of poly[d(AT)], effects on hyperchromicity of DNA, and circular dichroism. In addition, modelling studies were conducted to examine the electrostatic surface potential of the polycations. The results point to a key role for a large hydrophobic surface area on the steroid in addition to the Coulombic attraction by ammonium and guanidinium groups on the steroid interacting with the polyphosphate backbone.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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