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  • 1
    Electronic Resource
    Electronic Resource
    Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia (1996)
    [s.l.] : Nature Publishing Group
    Nature genetics 12 (1996), S. 448-451 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Targeting of the replacement vector (pExon8−) led to the deletion of Fac exon 8 and insertion of the neo gene after homologous recombination (Fig. 1a,b). Homozygous mice were produced by breeding offspring of the chimaeras (Fig. 1c). RT-PCR analysis demonstrated that exon 8 was absent from ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng0496-448
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    Paper (German National Licenses)
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  • 2
    Book
    Book
    Best computer papers (1974)
    New York u.a. :Petrocelli,
    Details
    Title: Best computer papers
    Author: Auerbach, Isaac L.
    Publisher: New York u.a. :Petrocelli,
    Year of publication: 1974
    Pages: Xiii, 346 S.
    Type of Medium: Book
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    ZIB Catalog
    Zuse Institute Berlin get availability status
  • 3
    Electronic Resource
    Electronic Resource
    Differential Effect of NMDA on Extracellular Serotonin in Rat Midbrain Raphe and Forebrain Sites (1996)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 66 (1996), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The contribution of NMDA receptors to regulation of serotonin (5-HT) release was assessed by in vivo microdialysis in freely behaving rats. During infusion of NMDA (30, 100, and 300 µM) into the dorsal raphe nucleus (DRN), 5-HT was increased by ∼25, 100, and 280%, respectively. Competitive and noncompetitive NMDA-receptor antagonists blocked this effect on DRN 5-HT. Infusion of NMDA (300 µM) into the DRN also produced an 80% increase in extracellular 5-HT in the nucleus accumbens. During infusion of NMDA (100 and 300 µM) into the median raphe nucleus (MRN), 5-HT was increased by ∼15 and 80%, respectively. NMDA-receptor antagonists blocked this effect on MRN 5-HT. Infusion of NMDA into the MRN also produced a significant increase in hippocampal 5-HT. In contrast, infusion of NMDA into the nucleus accumbens, frontal cortex, or hippocampus produced small decreases in 5-HT in these forebrain sites. Taken together, these results suggest that NMDA receptors in the midbrain raphe, but not the forebrain, can have an excitatory influence on 5-HT neurons and, thus, produce increased 5-HT release in the forebrain. Furthermore, in comparison with the MRN, DRN 5-HT neurons were more sensitive to the excitatory effect of NMDA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1996.66031067.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Modeling orientational randomization in zeolites: A new probe of intracage mobility, diffusion and cation disorder (1997)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 106 (1997), S. 2893-2905 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We have performed kinetic Monte Carlo simulations of benzene orientational randomization (BOR) and diffusion in Na-Y zeolite for various Na(II) occupancies and Na(II) spatial patterns. Full Na(II) occupancy gives BOR rates controlled by intracage motion, whereas half Na(II) occupancy gives BOR rates sensitive to both intracage and intercage motion, but insensitive to particular Na(II) spatial patterns. Alternatively, BOR with one quarter Na(II) occupancy demonstrates qualitative sensitivity to different Na(II) spatial patterns. Calculated diffusion coefficients vary weakly with decreasing Na(II) occupancy until ca. one Na(II) per supercage. Diffusion coefficients and mean square displacements reveal no information about intracage motion, and are insensitive to different spatial patterns of Na(II) cations. Our computational results thus suggest that measuring orientational randomization in zeolites can provide important information regarding intracage motion, diffusion and cation disorder. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.473352
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  • 5
    Electronic Resource
    Electronic Resource
    Analytical theory of benzene diffusion in Na-Y zeolite (1997)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 106 (1997), S. 7810-7815 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We have developed an analytical expression for the diffusion coefficient of benzene in Na-Y at infinite dilution in terms of fundamental rate coefficients, which has been confirmed by extensive kinetic Monte Carlo simulations. This model assumes that benzene jumps among SII and W binding sites, located near Na+ ions in 6-rings and in 12-ring windows, respectively. Our diffusion theory is based on D=〈fraction SHAPE="CASE"〉16ka2 where a≅11 Å is the intercage length and k is the cage-to-cage rate coefficient. We have determined that k=k(SII→W)⋅〈fraction SHAPE="CASE"〉12⋅3[1+k(W→W)/k(W→SII)], a finding that has resolved discrepancies between theory and simulation and has suggested new interpretations of benzene diffusion in Na-Y. When α(T)≡k(W→W)/k(W→SII) is between 0 and 1, the factor 3[1+α(T)] counts the number of thermally allowed target sites for cage-to-cage motion. Alternatively, when α(T)(very-much-greater-than)1, benzene mobility is interpreted as interstitial diffusion, wherein k is controlled by the probability of W site occupancy multiplied by the rate of W→W jump processes. This limit is expected to arise with benzene loadings of four molecules per supercage. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.473738
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Increased Extracellular Serotonin in Rat Brain After Systemic or Intraraphe Administration of Morphine (1994)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 63 (1994), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The effect of morphine on serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in the CNS of unanesthetized rats was investigated by microdialysis. Morphine was administered either subcutaneously, by local perfusion into the diencephalon, or by intraraphe microinjection. Systemic administration of morphine resulted in a significant increase in both extracellular 5-HT and 5-HIAA in the diencephalon. The effect of morphine on 5-HT was dose dependent during local perfusion of the diencephalon with inhibitors of uptake or monoamine oxidase. Systemic morphine also produced significant increases in extracellular 5-HT in the striatum and hippocampus during uptake inhibition. The site of opioid effects on 5-HT was tested by locally perfusing morphine into the diencephalon. This had no effect on 5-HT or 5-HIAA. In contrast, intraraphe injection of morphine caused a dose-dependent increase in extracellular 5-HT and 5-HIAA in the diencephalon. These results suggest that systemic morphine induces an increase in 5-HT release in widespread areas of the forebrain. This appears to be due to an effect on 5-HT cell bodies and not on 5-HT nerve endings in projection sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1994.63020517.x
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  • 7
    Electronic Resource
    Electronic Resource
    The Synthesis of Hydroxylamine Derivatives Possessing Hypocholesteremic Activity (1967)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 10 (1967), S. 556-564 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00316a012
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Transport Theory for Cationic Zeolites: Diffusion of Benzene in Na-Y (1995)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 99 (1995), S. 10600-10608 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100026a025
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  • 9
    Electronic Resource
    Electronic Resource
    Efficient polynomial expansion of the scattering Green's function: Application to the D+H2(v=1) rate constant (1994)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 100 (1994), S. 1103-1112 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We apply the absorbing boundary condition (ABC) discrete variable representation (DVR) theory of quantum reactive scattering to the initial state selected D+H2(v=1, j)→DH+H reaction. The ABC-DVR Green's function is efficiently computed by a Newton polynomial expansion. We compute accurate reaction probabilities for the total energies and angular momenta required to obtain the thermal rate constants kv=1, j(T). At T=310 K, a thermal average over j=(0,1,2,3) is performed to yield the final result kv=1(310 K)=1.87×10−13 cm3 molecule−1 s−1, in quantitative agreement with the most recent experimental value (1.9±0.2)×10−13 cm3 molecule−1 s−1. The J-shifting approximation using accurate J=0 reaction probabilities is tested against the exact results. It reliably predicts kv=1(T) for temperatures up to 700 K, but individual (v=1, j) selected rate constants are in error by as much as 41%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.466642
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  • 10
    Electronic Resource
    Electronic Resource
    Alignment of D2(v, J) desorbed from Cu(111): Low sensitivity of activated dissociative chemisorption to approach geometry (1996)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 105 (1996), S. 9702-9705 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We have determined the alignment of D2(v,J) desorbed from Cu(111). The measurements reveal a small preference for "helicoptering'' motion that increases with increasing J. At low J, the alignments are much smaller than predicted by recent calculations. We believe that the anisotropic potential may scramble the alignment as the molecules leave the surface. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.472979
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