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  • 1
    Digitale Medien
    Digitale Medien
    Synthesis and structure-activity relationships of acyclic .omega. chain conjugated diene analogs of enisoprost (1992)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 35 (1992), S. 694-704 
    Details
    ISSN: 1520-4804
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/jm00082a010
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  • 2
    Digitale Medien
    Digitale Medien
    Chemistry and structure-activity relationships of C-17 unsaturated 18-cycloalkyl and cycloalkenyl analogs of enisoprost. Identification of a promising new antiulcer prostaglandin (1990)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 33 (1990), S. 2784-2793 
    Details
    ISSN: 1520-4804
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/jm00172a017
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  • 3
    Digitale Medien
    Digitale Medien
    The normal menstrual cycle has no effect on gastric emptying (1985)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 92 (1985), S. 0 
    Details
    ISSN: 1471-0528
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary. Recent studies have demonstrated that orocaecal transit time is prolonged both in the luteal phase of the ovulatory cycle in normal women and during pregnancy, but have made no attempt to differentiate between the individual effects of gastric emptying and small intestinal transit. We have assessed the effect of the normal menstrual cycle on gastric emptying of solids and liquids in 10 women, using a dual isotope scintigraphic technique. In each subject gastric emptying was measured on 2 days: first during the follicular phase (day 8–10) and then during the luteal phase (day 18–20) of one ovulatory menstrual cycle (where day 1 was the first day of menstrual bleeding). Measures of solid and liquid gastric emptying did not change significantly between the follicular and luteal phases indicating that the normal menstrual cycle has no effect on gastric emptying.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-0528.1985.tb01458.x
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  • 4
    Digitale Medien
    Digitale Medien
    The efficacy of methotrexate in psoriasis—a review of 40 cases (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 17 (1992), S. 0 
    Details
    ISSN: 1365-2230
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Forty patients with psoriasis treated with methotrexatc (MTX) are reviewed. MTX was particularly effective in controlling; erythrodermic and generalized pustular psoriasis. The treatment was discontinued in seven patients due to nausea in two and because of abnormal laboratory tests in five. Two patients developed toxic epidermal necrolysis (TEN) and died. Patients under 60 years of age had a liver biopsy before treatment and repeat biopsy after each cumulative MTX dose of 1500 mg. We consider that MTX is the drug of choice for treating difficult psoriasis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2230.1992.tb02161.x
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  • 5
    Digitale Medien
    Digitale Medien
    8-MOP PUVA for psoriasis: a comparison of a minimal phototoxic dose-based regimen with a skin-type approach (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 135 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary Two ultraviolet A (UVA) regimens for oral S-methoxypsoralen (8-MOP) photochemotherapy (PUVA) for moderate/severe chronic plaque psoriasis using a half body study technique were compared. Each patient received both regimens. A higher-dose regimen based on minimal phototoxic dose (MPD) within percentage incremental increases was given to one-half of the body. The other half received a lower dose regimen based on skin type with fixed incremental UVA increases. Patients were treated twice weekly. Symmetrical plaques were scored to determine the rate of resolution with each regimen. In addition, the number of treatments, cumulative UVA dose and number of days in treatment to achieve overall clearance were recorded. Patients were reviewed monthly for 1 year to record remission data. Thirty-three patients completed the study. Both regimens were effective and well tolerated. With the MPD-based approach, the number of exposures was significantly less for patients with skin types I and II but not III. Although the cumulative UVA dose was higher with the MPU regimen for all skin types studied, the reduced number of exposures required for clearance for skin types I and II but not III, combined with thesecurity of individualized MPD testing, has practical attractions. MPD testing also identified live patients who required an increased psoralen dose and six patients who required a reduction of the initial UVA dose with the skin type regimen. Forty-two per cent were still clear 1 year after treatment and there was no significant difference in the number of days in remission between the regimens for those whose psoriasis had recurred. The reduction in the number of exposures required lor clearance with the MPD-based regimen may be safer and more cost effective in the long term.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2133.1996.tb01155.x
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  • 6
    Digitale Medien
    Digitale Medien
    Minocycline-induced pigmentation resolves after treatment with the Q-switched ruby laser (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 135 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary Four patients with minocycline-induced cutaneous pigmentation were treated with the Q-switched ruby laser. The pigmentation resolved and there was no adverse effects.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2133.1996.tb01171.x
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  • 7
    Digitale Medien
    Digitale Medien
    Plasma exchange therapy for solar urticaria (1996)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 134 (1996), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: We report two cases of severe idiopathic solar urticaria treated.1 with plasma exchange therapy. Previous treatment which included antihistamines and. in one patient, desensitization with psoralens and ultraviolet A (PUVA) and narrowband ultraviolet B phototherapy produced only partial benefit. The effect of plasma exchange therapy was assessed using monochromator phototesting and intradermal injection of in vitro irradiated serum. One patient responded but relapsed within 2 weeks. We have failed to demonstrate a lasting benefit from plasma exchange therapy (PExT) in the treatment of two patients with idiopathic solar urticaria.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1365-2133.1996.d01-908.x
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  • 8
    Digitale Medien
    Digitale Medien
    Inhibition of prostanoid synthesis by human gastric mucosa (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 1 (1987), S. 0 
    Details
    ISSN: 1365-2036
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Non-steroidal anti-inflammatory drugs (NSAIDs) damage the gastric mucosa, and an important part of this effect is probably due to inhibition of prostaglandin synthesis. We have therefore studied various drugs for their ability to reduce prostaglandin and thromboxane formation by human isolated gastric mucosa. The overall relative potencies for inhibiting the endogenous production of PGE, 6-keto-PGF1α and thromboxane B2 by mucosal pieces was generally: indomethacin = naproxen 〉 ibuprofen 〉 piroxicam; diflunisal, the prodrug sulindac, and the analgesic paracetamol usually had small or variable effects. This rank order was mainly similar to the inhibition of gastric microsomal PGE2 formation from exogenous arachidonic acid, the relative potencies being: indomethacin 〉 naproxen 〉 ibuprofen = piroxicam = diflunisal; again sulindac and paracetamol had little or no effect. The relative propensity of NSAIDs to cause gastric mucosal damage is controversial, but aspirin and indomethacin may be worst, and ibuprofen seems to be among the safest. Potency as an inhibitor of prostaglandin synthesis correlates better with the reported propensity for damage than does potency dose. For reasons that are given in the discussion, this may indicate that gastric mucosal damage by NSAIDs with short or moderate half-lives is due largely to locally absorbed drug. Whereas inhibition of prostaglandin synthesis is probably the major cause of the damage, the simultaneous reduction of thromboxane formation might be advantageous for gastric mucosal integrity. Various implications arise from our hypotheses concerning the design of anti-inflammatory drugs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2036.1987.tb00647.x
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  • 9
    Digitale Medien
    Digitale Medien
    Narrow-band UVB (TL-01) phototherapy: an effective preventative treatment for the photodermatoses (1995)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 132 (1995), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Summary Twenty patients with photodermatoses [actinic prurigo n=6), hydroa vacciniforme (n=4). idiopathic solar urticaria (n=1), amiodarone-induced photosensitivity (n=1) and a range of cutaneous porphyrias (n=8)] were treated with a ‘hardening’ course of narrow-band ultraviolet B (TL-01) phototherapy in springtime. The response to phototherapy was monitored subjectively, by interviewing patients after the summer, and objectively by monochromator phototesting, before and after phototherapy. Fifteen patients reported that treatment was worthwhile. Monochromator phototesting after phototherapy revealed a fourfold increase in the minimal erythema dose in those with abnormal photosensitivity to ultraviolet A wavebands. Adverse effects included erythema (seven patients), pruritus (five) and provocation of the eruption (four). We now routinely consider narrow-band UVB phototherapy for problem photodermatoses.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2133.1995.tb16955.x
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  • 10
    Digitale Medien
    Digitale Medien
    Photoallergic contact dermatitis to oxybenzone (1994)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 131 (1994), S. 0 
    Details
    ISSN: 1365-2133
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: A 21-year-old woman developed an erythematous papulovesicular eruption of photo-exposed sites, following the use of an oxybenzone-containing sunscreen. Patch testing, photopatch testing, phototesting, and histology produced findings strongly suggestive of oxybenzone photoallergy. Photopatch testing with a monochromator source showed abnormal UVA responses, with evidence of immediate urticaria, and delayed-onset dermatitis.Sun-barrier use is associated with a risk of the development of contact or photocontact allergic reactions. The benzophenones are frequently used in high-protection factor sun-barrier preparations, and appear to have a particular ability to induce such responses.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2133.1994.tb08469.x
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