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Digitale Medien

Aneuploid DNA pattern in human pituitary adenomas (1981)

Anniko, M. ; Holm, L. E. ; Tribukait, B. ; [weitere]

Springer

European archives of oto-rhino-laryngology and head & neck 230 (1981), S. 1-4

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Details

ISSN: 1434-4726

Schlagwort(e): Pituitary tumours ; DNA ; Histopathology ; Aneuploidy ; Hormone secretion

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary The DNA contents of 29 histologically and ultrastructurally benign pituitary tumours were analyzed with flow-cytofluorometry. — Cytogenetic malignancy, i.e., aneuploidy, was found in 12 cases, independent of endocrinological type of tumour. In 17 cases a diploid DNA content occurred. In aneuploid tumours varying percentage of cells in S-phase was found indicating different growth patterns. Aneuploid DNA pattern was often found in young patients with a short case history. Our findings indicate that analysis of cellular DNA content may reflect the biological properties of pituitary tumours, independent of morphologic characteristics and type of hormone secretion.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00665373

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