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  • 1
    Digitale Medien
    Digitale Medien
    Rapid identification of drug metabolites with tandem mass spectrometry (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 15 (1988), S. 193-204 
    Details
    ISSN: 0887-6134
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: A method which involves the use of tandem mass spectrometry (MS/MS) for the identification of drug metabolites has been demonstrated with a triple quadrupole mass spectrometer. The method is based on the fact that metabolites usually retain various substructures of the original drug molecule. MS/MS is capable of rapidly identifying molecules with characteristic substructures without prior separation. It is shown that this method makes it possible to postulate possible drug metabolite structures rapidly and systematically without the use of standards. The MS/MS method, as it was applied to the identification of the metabolites of a new antiepileptic drug, zonisamide, is discussed. In this case it was possible to identify isomeric metabolites due to their differences in vaporization times off the probe and their different daughter spectra. The complementary uses of the neutral loss and parent scans for the determination of the site of metabolism is demonstrated. A new figure of merit, the limit of identification, is introduced. The amount of the epoxide metabolite of carbamazepine necessary for its reliable identification in urine was shown to be 0.4 ng/μl. The application of various techniques to confirm preliminary findings with this MS/MS method are described.
    Zusätzliches Material: 12 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bms.1200150403
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  • 2
    Digitale Medien
    Digitale Medien
    Letter to the editor (1993)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 16 (1993), S. 52-52 
    Details
    ISSN: 0935-6304
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jhrc.1240160110
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  • 3
    Digitale Medien
    Digitale Medien
    Investigation into the Formation of Bubbles in Capillary Electrochromatography (1999)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 22 (1999), S. 29-32 
    Details
    ISSN: 0935-6304
    Schlagwort(e): Capillary electrochromatography ; electroosmotic flow ; frit ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The formation of bubbles in capillary electrochromatography (CEC) is well documented: possible origins include Joule heating and variations in EOF velocity on passing from the stationary phase through the frit and into the open tube. Methods for the prevention of bubble formation are discussed which are confirmed by experimental results. Using frit lengths varying from 1 mm to 6 mm it is shown how frit length is directly related to the likelihood of bubble formation and how this is affected by applied voltage. It is shown that the change in applied voltage across a capillary affects the formation of bubbles and also that rebonding octadecylsilane (ODS) onto the silica frit after formation of the frit can minimize the formation of bubbles and how this effects the chromatography. A method is also described for increasing the robustness of silica capillaries using a column coupler along with modifications made to conventional capillary electrophoresis equipment to cater for CEC.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
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  • 4
    Digitale Medien
    Digitale Medien
    A convenient computer program for calculation of Kováts retention indexes (1992)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 15 (1992), S. 478-479 
    Details
    ISSN: 0935-6304
    Schlagwort(e): Gas chromatography ; Kováts retention index ; GW-BASIC program ; Computer-assisted calculation ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jhrc.1240150714
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  • 5
    Digitale Medien
    Digitale Medien
    Determination of cyclopentolate by capillary column gas-liquid chromatography (1984)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 7 (1984), S. 144-146 
    Details
    ISSN: 0935-6304
    Schlagwort(e): Gas chromatography ; Capillary column ; Cyclopentolate ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jhrc.1240070310
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  • 6
    Digitale Medien
    Digitale Medien
    Isomerization of ionized toluene and cycloheptatriene on resonant excitation in a quadrupole ion-trap mass spectrometer (1994)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 29 (1994), S. 329-332 
    Details
    ISSN: 0030-493X
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/oms.1210290612
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  • 7
    Digitale Medien
    Digitale Medien
    Formation of the bicarbonate anion from deprotonated oxalic acid (1988)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 2 (1988), S. 275-276 
    Details
    ISSN: 0951-4198
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Physik
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/rcm.1290021207
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  • 8
    Digitale Medien
    Digitale Medien
    Do the benzyl and silabenzyl anions show similar ion chemistry in the gas phase? (1989)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 3 (1989), S. 293-294 
    Details
    ISSN: 0951-4198
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Physik
    Notizen: The ion PhSiH2- undergoes a number of fragmentations upon collisional activation, including losses of H·, H2 (mainly to form PhSi-), and SiH2, together with formation of HSi-. The ion/molecule chemistry of PhSiH2- is characteristic of silyl anion systems and bears no analogy to that of benzyl anion reactions; for example with N2O and CO2 it forms Ph(H)2SiO- as the sole ionic product, while with CS2 it yields Ph(H)2SiS-.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/rcm.1290030905
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  • 9
    Digitale Medien
    Digitale Medien
    Black canyons for ions stored in an ion-trap mass spectrometer (1992)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 6 (1992), S. 573-578 
    Details
    ISSN: 0951-4198
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Physik
    Notizen: Effects from higher order non-linear resonances, ‘black canyons’, have been observed for ions stored within the quadrupole ion-trap mass spectrometer. At specific qz values, higher-order field effects were observed to cause decreased intensity of chemical ionization (CI) reagent ions, due to ineffcient storage, as well as collision-induced dissociation. Efects have been observed, whether or not the CI reagent ions are mass-selected, and exibit increased severity with longer storage times. Previous reports have shown ‘black holes’ due to inefficient storage of product ions in tandem (MS/MS) spectra, but have reported no such effects in normal mass spectra. Without employing resonant excitation, higher-order field effects were investigated and found to occur continuously along iso-βz lines for βz = 1/3, 1/2, and 2/3. Described in this paper are the directs from higher-order fields on ions stored at specific az values, and indirec effects by those ions. Also described in this paper is new evidence for ‘black canyons’ occurring at βz = 1/3 at negative az values.
    Zusätzliches Material: 9 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/rcm.1290060908
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  • 10
    Digitale Medien
    Digitale Medien
    Quantitative relationships between the structure of β-adrenolytic and antihistamine drugs and their retention on an α1-acid glycoprotein HPLC column (1994)
    New York, NY : Wiley-Blackwell
    Biomedical Chromatography 8 (1994), S. 125-129 
    Details
    ISSN: 0269-3879
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Medizin
    Notizen: Chromatographic retention parameters of a series of 7 β-adrenolytics and of 12 antihistamine drugs were determined employing an α1-acid glycoprotein (AGP) high-performance liquid chromatographic (HPLC) column. For the group of antihistamines capillary electrophoretic (CE) retention was additionally measured in the presence of either AGP or human serum albumin (HSA). Two series of solutes hydrophobicity parameters were obtained by reversed-phase HPLC on an immobilized artificial membrane (IAM) column. The solutes studied were subjected to molecular modelling and the structural descriptors obtained were applied in studies of quantitative structure-retention (protein binding) relationships (QSRR). It was found that retention on AGP correlates well with the literature on physiological protein binding data. This retention was demonstrated to depend on hydrophobicity: to a lesser extent in the case of β-adrenolytics and strongly in the case of antihistamines. Hydrophobicity, along with molecular width and electron excess charge on aliphatic nitrogen was demonstrated to describe retention of antihistamines on AGP. The AGP column is recommended as a convenient reactor for studies of drug-protein interactions. Preliminary CE data do not correlate with the HPLC data.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bmc.1130080306
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