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  • 1
    Electronic Resource
    Electronic Resource
    PLASMA PROPRANOLOL CONCENTRATION IN PATIENTS WITH ANGINA AND ACUTE MYOCARDIAL INFARCTION (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 3 (1976), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Plasma levels of propranolol were measured fluorometrically in patients with angina pectoris and in patients admitted to the Coronary Care Unit with acute myocardial infarction.2. In thirty patients with stable angina pectoris, plasma propranolol levels varied almost linearly with doses between 10 and 120 mg during 6-hourly chronic oral administration. Plasma levels greater than 100 ng/ml produced 70–80% reduction in the tachycardia induced by strenous exercise on a treadmill.3. In nineteen patients with acute myocardial infarction given oral propranolol, 20 mg 6-hourly, peak as well as trough plasma levels of the drug increased progressively but remained below 100 ng/ml in all except two patients during the first 24 h after their admission to the Coronary Care Unit.4. The data suggest that the use of low and fixed doses of propranolol may not produce adequate plasma levels or significant β-adrenoceptor blockade in the early stages of acute myocardial infarction in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1976.tb00606.x
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  • 2
    Electronic Resource
    Electronic Resource
    EFFECTS OF AMIODARONE AND L8040, NOVEL ANTIANGINAL AND ANTIARRHYTHIC DRUGS, ON CARDIAC AND CORONARY HAEMODYNAMICS AND ON CARDIAC INTRACELLULAR POTENTIALS (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 3 (1976), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects on the coronary and systemic haemodynamics of intravenous and intracoronary injections of two benzfuran derivatives, amiodarone and its brominated analogue (L8040), were studied in open-chest anaesthetized dogs. The effects of L8040 on cardiac intracellular potentials after 6 weeks of 20 mg/kg intraperitoneal injections in rabbits were also investigated.2. Both compounds produced dose-related and quantitatively similar decreases in coronary vascular resistance following their intracoronary administration; threshold effects occurred with about 0.25 mg of each drug and maximal effects with 4 mg. Larger intracoronary doses produced measurable systemic effects.3. Intravenous injections of amiodarone and L8040 (2·5·10 mg/kg) produced dose-related decreases in heart rate and aortic pressure with a fall in total peripheral resistance. The left ventricular output was either unaffected or increased with a consistent augmentation in stroke volume.4. The bradycardia produced by both drugs was associated with prolongation of the P–R interval of the electrocardiogram with no significant effect on the QRS duration or the Q–T interval.5. Each drug produced a decrease in the total peripheral vascular resistance with no change in left ventricular end diastolic pressure except after 10 mg/kg doses which led to an increase in this parameter.6. Cardiac contractile force and peak LV dp/dt were reduced by both drugs in a dose-related manner.7. Chronic intraperitoneal administration of L8040 in rabbits caused a prolongation of the duration of the atrial and ventricular intracellular potential without an effect on the maximal rate of depolarization.8. The effects of amiodarone or L8040 on the coronary circulation and arterial pressure may be attributed to their vasodilator properties but their depressant actions on cardiac contractile force and peak LV dp/dt with an increase in left ventricular end diastolic pressure at high doses, also suggest intrinsic negative inotropic propensity for both compounds.9. It is concluded that the overall effects on coronary and systemic haemodynamics of amiodarone and its brominated analogue are likely to permit a favourable influence on the balance of oxygen supply and demand in myocardial ischaemia; in addition, their actions on sinoatrial and atrio-ventricular conduction as well as those on cardiac repolarization suggest potential antiarrhythmic properties which merit investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1976.tb00620.x
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  • 3
    Electronic Resource
    Electronic Resource
    Silica Jelly as a Substrate for Counting Holozoic Protozoa (1946)
    [s.l.] : Nature Publishing Group
    Nature 157 (1946), S. 302-302 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE study of selective feeding... of soil protozoa, especially amœbæ on a large number of bacterial strains, led to the development of an improved method6 of counting soil Protozoa. In the past, dilution methods7 of estimating Protozoa numbers have suffered, first ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/157302b0
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  • 4
    Electronic Resource
    Electronic Resource
    Soil Acrasieæ and their Bacterial Food Supply (1946)
    [s.l.] : Nature Publishing Group
    Nature 157 (1946), S. 133-134 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ALTHOUGH the genera Dictyostelium and Polysphondylium were created by Brefeld1,2 in 1869 and 1884, no study has been made in Britain of that interesting group, the Acrasieæ, to which they belong. The occurrence of Dictyostelium in Polish and American soils has been recorded by ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/157133b0
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  • 5
    Electronic Resource
    Electronic Resource
    Factors Contributing to the Bacteriolytic Effect of Species of Myxococci upon Viable Eubacteria (1946)
    [s.l.] : Nature Publishing Group
    Nature 158 (1946), S. 745-745 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ALTHOUGH the lytic effect of certain myxobacteria upon the true bacteria (eubacteria) has been known for some years1–4, the mechanism of the process is imperfectly understood, and no one seems hitherto to have studied the possible production of antibiotic substances by the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/158745a0
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  • 6
    Electronic Resource
    Electronic Resource
    Occurrence and Nature of an Amœba Excystment Factor produced by Aerobacter sp. (1956)
    [s.l.] : Nature Publishing Group
    Nature 177 (1956), S. 621-622 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Crump1 showed that excystment in Amoeba Z (Didascalus ihorntoni ; Singh6) took place without the presence of bacteria, while Amoeba 4 (Schizo-pyrenus russelli; Singh6) excysted only in the presence of certain bacteria (Aerobacter sp. and 4036). She suggested that the two species of bacteria produce ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/177621a0
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  • 7
    Electronic Resource
    Electronic Resource
    Nuclear Division in AmŒbÆ and its Bearing on Classification (1951)
    [s.l.] : Nature Publishing Group
    Nature 167 (1951), S. 582-584 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN the past, the order Amoebida Calkins has been divided into families on such characters as the presence of a flagellate stage under certain physiological conditions, their parasitic or free-living nature, the possession of an accessory body called Neben-korper, etc. Such a system is not based on ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/167582a0
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  • 8
    Electronic Resource
    Electronic Resource
    Respiratory adaptations in the larvae of Monoptems cuchia (Ham.) (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 34 (1989), S. 0 
    Details
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1095-8649.1989.tb03343.x
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  • 9
    Electronic Resource
    Electronic Resource
    Abscisic acid levels and metabolism in the leaf epidermal tissue of Tulipa gesneriana L. and Commelina communis L. (1979)
    Springer
    Planta 146 (1979), S. 135-138 
    Details
    ISSN: 1432-2048
    Keywords: Abscisic acid ; Commelina ; Leaf epidermal tissue ; Radioimmunoassay (ABA) ; Tulipa ; Water stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We have shown the presence of abscisic acid (ABA) in abaxial epidermal strips taken from Tulipa gesneriana and Commelina communis and that the ABA level rises in the epidermis when leaves are water stressed. ABA levels had risen 50% in the abaxial epidermis of C. communis 30 min after the leaves lost 10% of their fresh weight. Epidermis from both T. gesneriana and C. communis metabolize [14C]ABA to several products probably including phaseic acid (PA) and dihydrophaseic acid (DPA).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00388223
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  • 10
    Electronic Resource
    Electronic Resource
    Cardiac and respiratory responses in the climbing perchAnabas testudineus (1973)
    Springer
    Journal of comparative physiology 84 (1973), S. 205-226 
    Details
    ISSN: 1432-1351
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The heart rate ofAnabas is about 40 beats/min when breathing water and air. Tachycardia occurs as the fish takes an air breath and the rate declines as the breath holding continues but water breathing stops. Bradycardia is observed during this later phase. By the time the next air breath is taken, the heart rate has dropped to 15–30 beats/min. The heart rate of a fish breathing normoxic water but prevented from surfacing is about 42/min. Bradycardia occurs in hypoxic water under similar conditions. Tachycardia is observed in active fish when breathing hypercarbic water and air. On exposure to air bradycardia is found in resting fish but tachycardia occurs during activity. In air,Anabas usually repeats a breath when the heart rate drops to 15–25 beats/min. Tachycardia occurs immediately following an air breath. Heart rate then returns over a period of 3–6 mins to the normal resting level of 30 beats/min. The gas composition of the suprabranchial chambers has been measured and its relationship with the occurrence of an air breath, tachycardia and bradycardia is described. The experimental results are discussed in relation to the anatomy of the blood supply to the respiratory organs. The possible role of respiratory gases and pH in the control of breathing and perfusion is also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00697607
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