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  • 1
    Digitale Medien
    Digitale Medien
    K-7259: A Cardioprotective Derivative of Dilazep (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Cardiovascular drug reviews 15 (1997), S. 0 
    Details
    ISSN: 1527-3466
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1527-3466.1997.tb00340.x
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  • 2
    Digitale Medien
    Digitale Medien
    Ranolazine:an Antiischemic Drug with a Novel Mechanism of Action (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Cardiovascular drug reviews 17 (1999), S. 0 
    Details
    ISSN: 1527-3466
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1527-3466.1999.tb00004.x
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  • 3
    Digitale Medien
    Digitale Medien
    Thromboxane A 2 and prostaglandin F 2α mediate inflammatory tachycardia (2005)
    [s.l.] : Nature Publishing Group
    Nature medicine 11 (2005), S. 562-566 
    Details
    ISSN: 1546-170X
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Medizin
    Notizen: [Auszug] Systemic inflammation induces various adaptive responses including tachycardia. Although inflammation-associated tachycardia has been thought to result from increased sympathetic discharge caused by inflammatory signals of the immune system, definitive proof has been lacking. Prostanoids, including ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/nm1231
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  • 4
    Digitale Medien
    Digitale Medien
    Antinociceptive effects of neonatal capsaicin in rats with adjuvant arthritis (1984)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 326 (1984), S. 248-253 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Neonatal capsaicin ; Antinociceptive effects ; Adjuvant arthritis ; Substance P ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Rats were treated with capsaicin (50 mg/kg, SC) either on the second day or on the second and third days of life. A significant attenuation of the responses to noxious stimuli was obtained in the capsaicin treated animals as measured by the hot-plate or paw pressure tests but not by the tail-flick test. Furthermore, neonatal capsaicin produced a significant reduction of response in the formalin test. Capsaicin reduced the reaction latency in rats with adjuvant arthritis as measured by the hot-plate and paw pressure tests, though capsaicin did not alter the overall time course of the response to Freund's adjuvant. Capsaicin also attenuated the weight loss or the decreased ambulatory and rearing behaviour which occurred in the control animals with adjuvant arthritis. It is suggested that neonatal treatment with capsaicin may relieve the responsiveness to longlasting nociceptive stimuli by adjuvant in rats.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00505326
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  • 5
    Digitale Medien
    Digitale Medien
    Beneficial effect of magnesium on the isolated perfused rat heart during reperfusion after ischaemia: Comparison between pre-ischaemic and post-ischaemic administration of magnesium (1990)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 342 (1990), S. 100-106 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Magnesium ; Cardiac function ; Energy metabolism ; Myocardium ; Reperfusion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effect of high concentration of magnesium on both mechanical dysfunction and metabolic damage after ischaemia-reperfusion was studied in isolated rat hearts. The heart was perfused by the Langendorff's technique at a constant flow (10 ml/min) with modified Krebs-Henseleit solution and driven at 300 beats/min. The heart was made ischaemic by reducing the flow to 0 ml/min for 25 min, and then reperfused at the constant flow for 15 min. MgSO4 was added to the perfusate for 5 min before the onset of ischaemia, or after the end of ischaemia (after the onset of reperfusion). Ischaemia-reperfusion produced both mechanical dysfunction (as evidenced by an increase in the left ventricular end diastolic pressure and a decrease in the left ventricular developed pressure) and metabolic damage [as evidenced by a decrease in the myocardial adenosine triphosphate (ATP)]. When 15 mmol/l MgSO4 was given before ischaemia, there was no appreciable recovery of mechanical function, whereas when given after ischaemia (during reperfusion), there was a marked recovery of mechanical function. Lower concentrations (10 or 5 mmol/l) of MgSO4 given after ischaemia recovered the mechanical function concentration-dependently. The beneficial effect of 15 mmol/l MgSO4 was minimized by the coexistence of 4.5 mmol/l CaCl2 in the reperfusion solution. The decrease in the myocardial level of ATP induced by ischaemia-reperfusion was attenuated by 15 mmol/l MgSO4 given in the reperfusion solution. These results suggest that high Mg2+ is effective in attenuating both functional and metabolic damage of the post-ischaemic heart, provided it is given after ischaemia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00178980
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  • 6
    Digitale Medien
    Digitale Medien
    Relationship between coronary flow and adenosine release during severe and mild hypoxia in the isolated perfused rat heart with special reference to time-course change (1987)
    Springer
    Heart and vessels 3 (1987), S. 113-121 
    Details
    ISSN: 1615-2573
    Schlagwort(e): Heart ; Coronary flow ; Adenosine ; Lactate ; Myoglobin ; Oxygen ; Hypoxia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The contribution of endogenous adenosine to coronary vasodilation induced by global myocardial hypoxia was examined. In isolated rat hearts perfused by means of Langendorff's technique, the relationship between chronological changes in coronary flow and adenosine release during hypoxia was analyzed. The oxygenation level of myoglobin (MbO2), myocardial oxygen uptake, lactate release, and left ventricular pressure (LVP) was also measured. Adenosine was determined by radio-immunoassay, and the MbO2 levels by the optical method. Severe hypoxia (20% O2+75% N2+5% CO2) increased coronary flow, adenosine release, and lactate release and decreased both myocardial oxygen uptake and LVP. Mild hypoxia (50% O2+45%N2+5%CO2) also increased coronary flow, adenosine release, and lactate release, while it affected neither myocardial oxygen uptake nor LVP. These results suggest that the oxygen supply is compensated by an increase in coronary flow in mild hypoxia, whereas this does not occur in severe hypoxia. Changes in MbO2 were the reverse of those in coronary flow during severe hypoxia, confirming that a decrease in intracellular oxygen correlates well with an increase in coronary flow. The pattern of changes in adenosine release, however, was not identical with that in coronary flow in severe and mild hypoxia, indicating that there is no significant relationship between coronary flow and adenosine release in either severe or mild hypoxic hearts. These findings suggest that adenosine is not the only metabolic mediator of regulation of coronary flow in hypoxic hearts.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02058786
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  • 7
    Digitale Medien
    Digitale Medien
    Effect of diltiazem on the oxymyoglobin level of myocardial cells in the isolated, perfused rat heart during hypoxia (1990)
    Springer
    Cardiovascular drugs and therapy 4 (1990), S. 719-722 
    Details
    ISSN: 1573-7241
    Schlagwort(e): diltiazem ; oxymyoglobin ; hypoxia ; isolated heart ; Langendorff perfusion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The effect of diltiazem on the oxymyoglobin level was studied in the isolated rat heart during hypoxia. The heart was perfused with Krebs-Henseleit solution equilibrated with a gas mixture containing 95% O2+5% CO2 (normoxic perfusion solution) at a constant flow rate (9 ml/min) according to Langendorff's method. All the hearts were paced at 300 beats/min. The myocardial oxymyoglobin level (i.e., intracellular oxygen level) of the left ventricular surface was continuously measured by means of an optical technique. Diltiazem (infused into the aortic cannula for 10 minutes at concentrations of 0.72, 2.41, or 4.82 μM, expressed as the final concentration in the solution) decreased, the left ventricular pressure (LVP) and perfusion pressure (PP) dose dependently, and did not change the oxymyoglobin (MbO2) level during normoxic perfusion. Hypoxic perfusion (using a gas mixture containing 30% O2+5% CO2+65% N2) decreased the MbO2, LVP, and PP. Diltiazem (infused 5 minutes after the hypoxic perfusion) at a concentration of 2.41 or 4.82 μM increased the MbO2 level and further decreased the LVP, without affecting the PP. The low concentration (0.72 μM) of diltiazem, however, had practically no effect on these parameters. In summary, diltiazem in high concentrations decreased the LVP and increased the intracellular oxygen level of the myocardial cells during hypoxia, but not during normoxia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01856560
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