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Digitale Medien

Predicting the Strongest Domain-Domain Contact in Interacting Protein Pairs (2006)

Nye, Tom M. W. ; Berzuini, Carlo ; Gilks, Walter R ; [weitere]

Berkeley, Calif. : Berkeley Electronic Press (now: De Gruyter)

Statistical applications in genetics and molecular biology 5.2006, 1, art5

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ISSN: 1544-6115

Quelle: Berkeley Electronic Press Academic Journals

Thema: Biologie

Notizen: Experiments to determine the complete 3-dimensional structures of protein complexes are difficult to perform and only a limited range of such structures are available.In contrast, large-scale screening experiments have identified thousands of pairwise interactions between proteins, but such experiments do not produce explicit structural information.In addition, the data produced by these high through-put experiments contain large numbers of false positive results, and can be biased against detection of certain types of interaction.Several methods exist that analyse such pairwise interaction data in terms of the constituent domains within proteins, scoring pairs of domain superfamilies according to their propensity to interact.These scores can be used to predict the strongest domain-domain contact (the contact with the largest surface area) between interacting proteins for which the domain-level structures of the individual proteins are known.We test this predictive approach on a set of pairwise protein interactions taken from the Protein Quaternary Structure (PQS) database for which the true domain-domain contacts are known.While the overall prediction success rate across the whole test data set is poor, we shown how interactions in the test data set for which the training data are not informative can be automatically excluded from the prediction process, giving improved prediction success rates at the expense of restricted coverage of the test data.

Materialart: Digitale Medien

URL: http://www.bepress.com/sagmb/vol5/iss1/art5

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Digitale Medien

VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION * (2005)

Kew, Olen M. ; Sutter, Roland W. ; de Gourville, Esther M. ; [weitere]

Palo Alto, Calif. : Annual Reviews

Annual Review of Microbiology 59 (2005), S. 587-635

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ISSN: 0066-4227

Quelle: Annual Reviews Electronic Back Volume Collection 1932-2001ff

Thema: Biologie

Notizen: As the global eradication of wild poliovirus nears, the World Health Organization (WHO) is addressing challenges unprecedented in public health. The live, attenuated oral poliovirus vaccine (OPV), used for more than four decades to interrupt poliovirus transmission, and the vaccine of choice for developing countries, is genetically unstable. Reversion of the small number of substitutions conferring the attenuated phenotype frequently occurs during OPV replication in humans and is the underlying cause of the rare cases of vaccine-associated paralytic poliomyelitis (VAPP) in OPV recipients and their close contacts. Whereas VAPP has long been recognized, two other adverse events have been identified more recently: (a) long-term excretion of highly evolved vaccine-derived polioviruses (VDPVs) in persons with primary immunodeficiencies, and (b) polio outbreaks associated with circulating VDPVs in areas with low rates of OPV coverage. Developing a posteradication strategy to minimize the risks of VDPV emergence and spread has become an urgent WHO priority.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1146/annurev.micro.58.030603.123625

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Digitale Medien

Dissemination and Evaluation of Marriage Education in the Army (2005)

Stanley, Scott M. ; Allen, Elizabeth S. ; Markman, Howard J. ; [weitere]

Oxford, UK : Blackwell Publishing

Family process 44 (2005), S. 0

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ISSN: 1545-5300

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Psychologie

Notizen: The effectiveness of marriage education was evaluated in two separate samples of primarily married couples in which at least one member of the couple was on active duty in the U.S. Army. The intervention was delivered by Army chaplains. Effects replicated well in the two samples, and demonstrated that marriage education was well received by this population and resulted in improvements in relationship functioning. Changes in relationship quality were examined separately for males and females, and also for couples in which both members of the couple were Caucasian as compared with all other couples. There were no significant differences in changes over time (i.e., from pre- to postmarriage education) among males and females or among couples with different ethnic makeup. These results have important implications for the generalizability of marriage education to diverse samples in nontraditional contexts.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1545-5300.2005.00053.x

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Digitale Medien

An Anisotropic Model for the Plastic Response of Powder Compacts (2007)

Ruziwa, Walter R. ; Cocks, Alan C.F.

s.l. ; Stafa-Zurich, Switzerland

Materials science forum Vol. 561-565 (Oct. 2007), p. 1809-1812

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ISSN: 1662-9752

Quelle: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008

Thema: Maschinenbau

Notizen: In this paper we present an anisotropic compaction model based on a genericmodeling framework. The model is a generalization of Hill’s anisotropic model tocompressible materials and reduces to a Cam-clay type model in the isotropic limit. Themodel has been calibrated using experimental data for a commercial steel powderobtained from a computer controlled triaxial cell in which the yield surface was probedfollowing loading along different paths in stress and strain space. Closed-formanalytical expressions are presented for the yield surface as a function of the inelasticstrain. The model has been implemented in the general purpose finite element codeABAQUS. Simulations are presented which explore the effect of a detailed structure ofthe constitutive law on the compaction response

Materialart: Digitale Medien

URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/18/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.561-565.1809.pdf

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