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  • 1990-1994  (4)
  • Mefloquine  (3)
  • Clarias macrocephalus  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Effect of ampicillin on mefloquine pharmacokinetics in thai males (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 631-633 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Mefloquine ; ampicillin ; Thai subjects ; pharmacokinetics ; enterohepatic recycling ; drug interaction ; adverse effects
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The kinetics of a single oral dose of mefloquine given either alone or with ampicillin has been studied in 8 healthy Thai male volunteers. There was a significantly higher maximum whole blood mefloquine concentration after coadministration with ampicillin (1648 vs 1228 ng·ml−1), as well as a significantly reduced terminal half life (15.3 vs 17.7 days), mean residence time (20.1 vs 23.4 days) and volume of distribution at steady state (14.1 vs 19.4 l·kg−1). Although there was no significant change in the AUC from zero time to infinity, the AUC from zero time to 5 days was significantly increased by ampicillin (4.86 vs 3.27 μg·ml−1 day). These changes in mefloquine disposition after antibiotic treatment may be due both to an increase in fractional bioavailability and a reduction in the enterohepatic recycling of mefloquine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00279985
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  • 2
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of mefloquine in the presence of primaquine (1992)
    Springer
    European journal of clinical pharmacology 42 (1992), S. 559-560 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Mefloquine ; Thai subjects ; pharmacokinetics ; Primaquine ; drug interaction ; adverse effects
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00314870
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  • 3
    Digitale Medien
    Digitale Medien
    Effect of tetracycline on mefloquine pharmacokinetics in Thai males (1992)
    Springer
    European journal of clinical pharmacology 43 (1992), S. 567-569 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Mefloquine ; Tetracycline ; Thai subjects ; Thai subjects ; drug interaction ; pharmacokinetics ; adverse effects
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The kinetics of a single oral dose of mefloquine given either alone or with tetracycline has been studied in 20 healthy Thai male volunteers. There was a significantly higher maximum whole blood mefloquine concentration after coadministration with tetracycline (1600 vs 1160 ng · ml−1), as well as a significantly reduced terminal half-life (14.4 vs 19.3 days), mean residence time (11.9 vs 16.0 days) and volume of distribution at steady state (13.3 vs 19.91 · kg−1). Although there was no significant change in the AUC from zero time to infinity, the AUC from zero time to 7 days was significantly increased by tetracycline (6.18 vs 4.76 μg · ml−1 · day). The changes in mefloquine disposition after tetracycline treatment are probably due to a reduction in enterohepatic recycling. The initial increase in mefloquine AUC without an apparent increase in side-effects suggests that this combination may have a place in the treatment of multi-drug resistant falciparum malaria.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02285105
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  • 4
    Digitale Medien
    Digitale Medien
    Chromosome study of hybrid and gynogenetic offspring of artificial crosses between members of the catfish families Clariidae and Pangasiidae (1993)
    Springer
    Environmental biology of fishes 37 (1993), S. 317-322 
    Details
    ISSN: 1573-5133
    Schlagwort(e): Interfamilial hybridization ; Hybrid morphotypes ; Triploid ; Clarias macrocephalus ; Pangasius sutchi ; Fishes
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Synopsis Artificial hybridization between species of the catfish families Clariidae (Clarias macrocephalus) and Pangasiidae (Pangasius sutchi) resulted in first generation offspring comprising two intermediate morphotypes and one morphotype indistinguishable from its clariid parent. The two intermediate morphotypes apparently correspond to hybrid morphotypes 2 and 4 resulting from earlier hybridization experiments between the same parent species (Tarnchalanukit 1986). We did not obtain morphotypes 1 and 3. Chromosome spreads of the relatively pangasiid-like morphotype 2 reveal a diploid number of 57, presumably comprising one set of Clarias (n=27) and one of Pangasius (n=30) chromosomes. The relatively clariid-like morphotype 4 is a triploid with 84 chromosomes, presumably comprising two sets from Clarias (2n=54) and one from Pangasius (n=30). Finally, the morphotype indistinguishable from Clarias, is a diploid with 54 chromosomes, apparently arising from gynogenesis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00004639
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